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Target not currently curated in GtoImmuPdb
Target id: 875
Nomenclature: Glucose transporter 1
Abbreviated Name: GLUT1
Systematic Nomenclature: SLC2A1
Family: Class I transporters
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 12 | 492 | 1p34.2 | SLC2A1 | solute carrier family 2 member 1 | |
Mouse | 12 | 492 | 4 | Slc2a1 | solute carrier family 2 (facilitated glucose transporter), member 1 | |
Rat | 12 | 492 | 5q36 | Slc2a1 | solute carrier family 2 member 1 |
Database Links | |
Specialist databases | |
Bioparadigms SLC Tables | SLC2A1 (Hs) |
RESOLUTE | SLC2A1 (Hs) |
Other databases | |
Alphafold | P11166 (Hs), P17809 (Mm), P11167 (Rn) |
ChEMBL Target | CHEMBL2535 (Hs), CHEMBL5214 (Rn) |
Ensembl Gene | ENSG00000117394 (Hs), ENSMUSG00000028645 (Mm), ENSRNOG00000007284 (Rn) |
Entrez Gene | 6513 (Hs), 20525 (Mm), 24778 (Rn) |
Human Protein Atlas | ENSG00000117394 (Hs) |
KEGG Gene | hsa:6513 (Hs), mmu:20525 (Mm), rno:24778 (Rn) |
OMIM | 138140 (Hs) |
Pharos | P11166 (Hs) |
UniProtKB | P11166 (Hs), P17809 (Mm), P11167 (Rn) |
Wikipedia | SLC2A1 (Hs) |
Download all structure-activity data for this target as a CSV file
Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||
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General Comments |
GLUT1 overexpression is associated with aberant glucose transport observed in many types of cancer cells [1,7,10], may enhance metastasis [5], and is often a marker of poor prognosis [3-4,8,10]. GLUT1 overexpression allows these cells to survive in hypoxic microenvironments [2,6]. GLUT1 inhibitors can cause apoptotic death in cancer cells whilst sparing normal cells, making GLUT1 a molecular target for drug discovery. |
1. Brown RS, Wahl RL. (1993) Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer, 72 (10): 2979-85. [PMID:8221565]
2. Calvo MB, Figueroa A, Pulido EG, Campelo RG, Aparicio LA. (2010) Potential role of sugar transporters in cancer and their relationship with anticancer therapy. Int J Endocrinol, 2010. [PMID:20706540]
3. Furudoi A, Tanaka S, Haruma K, Yoshihara M, Sumii K, Kajiyama G, Shimamoto F. (2001) Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma. Oncology, 60 (2): 162-9. [PMID:11244332]
4. Haber RS, Rathan A, Weiser KR, Pritsker A, Itzkowitz SH, Bodian C, Slater G, Weiss A, Burstein DE. (1998) GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer, 83 (1): 34-40. [PMID:9655290]
5. Koch A, Lang SA, Wild PJ, Gantner S, Mahli A, Spanier G, Berneburg M, Müller M, Bosserhoff AK, Hellerbrand C. (2015) Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget, 6 (32): 32748-60. [PMID:26293674]
6. Macheda ML, Rogers S, Best JD. (2005) Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol, 202 (3): 654-62. [PMID:15389572]
7. Rudlowski C, Becker AJ, Schroder W, Rath W, Büttner R, Moser M. (2003) GLUT1 messenger RNA and protein induction relates to the malignant transformation of cervical cancer. Am J Clin Pathol, 120 (5): 691-8. [PMID:14608894]
8. Saigusa S, Toiyama Y, Tanaka K, Okugawa Y, Fujikawa H, Matsushita K, Uchida K, Inoue Y, Kusunoki M. (2012) Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy. Surg Today, 42 (5): 460-9. [PMID:22072148]
9. Wang D, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. (2012) Development of a novel class of glucose transporter inhibitors. J Med Chem, 55 (8): 3827-36. [PMID:22468970]
10. Younes M, Brown RW, Stephenson M, Gondo M, Cagle PT. (1997) Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer, 80 (6): 1046-51. [PMID:9305704]
Class I transporters: Glucose transporter 1. Last modified on 20/10/2015. Accessed on 10/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=875.