target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id Ecto-5'-Nucleotidase,1232,P21588,Rat,PSB-0963,9023,,91934096,O=C1c2ccccc2C(=O)c2c1c(N)c(cc2Nc1ccc2c(c1)cc1c(c2)cccc1)S(=O)(=O)[O-],"InChI=1S/C28H18N2O5S/c29-26-23(36(33,34)35)14-22(24-25(26)28(32)21-8-4-3-7-20(21)27(24)31)30-19-10-9-17-11-15-5-1-2-6-16(15)12-18(17)13-19/h1-14,30H,29H2,(H,33,34,35)/p-1",JXFRJOYKTCEJDG-UHFFFAOYSA-M,Inhibitor,Inhibition,,,,,pKi,,6.82,,Ki,,150.0,,=,,,,20146483, Ecto-5'-Nucleotidase,1232,P21589,Human,oleclumab,9596,,,,,,Antibody,Binding,,,yes,,pKd,,11.38,,Kd,,0.0042,,=,,,,26854859, Ecto-5'-Nucleotidase,1232,P21589,Human,compound 15 [PMID: 32045236],10706,,145996542,O[C@@H]1[C@@H](COP(=O)(CP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1nc(I)nc2N,"InChI=1S/C11H16IN5O9P2/c12-11-15-8(13)5-9(16-11)17(2-14-5)10-7(19)6(18)4(26-10)1-25-28(23,24)3-27(20,21)22/h2,4,6-7,10,18-19H,1,3H2,(H,23,24)(H2,13,15,16)(H2,20,21,22)/t4-,6-,7-,10-/m1/s1",OJRUSAPKCPIVBY-KQYNXXCUSA-N,Inhibitor,Inhibition,,,,,pKi,,8.48,,Ki,,3.33,,=,Inhibition of CD73 in human MDA-MB-231 cancer cells.,,,32045236, Ecto-5'-Nucleotidase,1232,P21589,Human,compound 15 [PMID: 32045236],10706,,145996542,O[C@@H]1[C@@H](COP(=O)(CP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1nc(I)nc2N,"InChI=1S/C11H16IN5O9P2/c12-11-15-8(13)5-9(16-11)17(2-14-5)10-7(19)6(18)4(26-10)1-25-28(23,24)3-27(20,21)22/h2,4,6-7,10,18-19H,1,3H2,(H,23,24)(H2,13,15,16)(H2,20,21,22)/t4-,6-,7-,10-/m1/s1",OJRUSAPKCPIVBY-KQYNXXCUSA-N,Inhibitor,Inhibition,,,,,pKi,,8.44,,Ki,,3.59,,=,Ki vs. soluble human CD73 in vitro.,,,32045236, Ecto-5'-Nucleotidase,1232,P21588,Rat,compound 15 [PMID: 32045236],10706,,145996542,O[C@@H]1[C@@H](COP(=O)(CP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1nc(I)nc2N,"InChI=1S/C11H16IN5O9P2/c12-11-15-8(13)5-9(16-11)17(2-14-5)10-7(19)6(18)4(26-10)1-25-28(23,24)3-27(20,21)22/h2,4,6-7,10,18-19H,1,3H2,(H,23,24)(H2,13,15,16)(H2,20,21,22)/t4-,6-,7-,10-/m1/s1",OJRUSAPKCPIVBY-KQYNXXCUSA-N,Inhibitor,Inhibition,,,,,pKi,,7.82,,Ki,,15.1,,=,Ki vs. soluble rat CD73 in vitro.,,,32045236, Ecto-5'-Nucleotidase,1232,P21589,Human,quemliclustat,10707,,130205852,O[C@@H]1[C@H](O)[C@H](O[C@H]1n1ncc2c1nc(Cl)cc2N[C@H](c1ccccc1F)C)COP(=O)(CP(=O)(O)O)O,"InChI=1S/C20H24ClFN4O9P2/c1-10(11-4-2-3-5-13(11)22)24-14-6-16(21)25-19-12(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1",MFYLCAMJNGIULC-KCVUFLITSA-N,Inhibitor,Inhibition,,,,,pKi,,11.3,,Ki,,0.005,,=,,,,31334635, Ecto-5'-Nucleotidase,1232,P21589,Human,mupadolimab,11758,,,,,,Antibody,Inhibition,,,yes,,pKd,,8.15,,Kd,,7.1,,=,,,,, Ecto-5'-Nucleotidase,1232,P21589,Human,dalutrafusp alfa,11776,,,,,,Antibody,Binding,,,,,pKd,,10.16,,Kd,,0.069,,=,,,,, Ecto-5'-Nucleotidase,1232,P21589,Human,compound 49 [PMID: 36529947],12355,,146276619,Clc1nc(N)c2c(n1)n(cn2)[C@H]1[C@H](O)[C@@](O)(C#C)[C@@H](COC(C(=O)O)(Cc2ccc(N3C(=O)NCCC3)cc2)C(=O)O)O1,"InChI=1S/C26H26ClN7O9/c1-2-25(41)15(43-20(17(25)35)34-12-30-16-18(28)31-23(27)32-19(16)34)11-42-26(21(36)37,22(38)39)10-13-4-6-14(7-5-13)33-9-3-8-29-24(33)40/h1,4-7,12,15,17,20,35,41H,3,8-11H2,(H,29,40)(H,36,37)(H,38,39)(H2,28,31,32)/t15-,17+,20-,25-/m1/s1",ROWSPNRRBJYDCU-IRJNKLFQSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.77,,IC50,,0.17,,=,,,,36529947,