target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id Leukotriene A4 hydrolase,1395,P09960,Human,bestatin,5151,,439299,O[C@H](C(=O)N[C@@H](C(=O)O)CC(C)C)[C@@H](Cc1ccccc1)N,"InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14+/m1/s1",VGGGPCQERPFHOB-MCIONIFRSA-N,Inhibitor,Inhibition,,,,,pKi,,5.4,,Ki,,4000.0,,=,Inhibition of LTB4 formation by isolated human enzyme in vitro.,,,1846352, Leukotriene A4 hydrolase,1395,P09960,Human,DG-051,6548,,44537807,OC(=O)CCCN1CCC[C@H]1COc1ccc(cc1)Oc1ccc(cc1)Cl,"InChI=1S/C21H24ClNO4/c22-16-5-7-19(8-6-16)27-20-11-9-18(10-12-20)26-15-17-3-1-13-23(17)14-2-4-21(24)25/h5-12,17H,1-4,13-15H2,(H,24,25)/t17-/m0/s1",PVCTYSQBVIGZRU-KRWDZBQOSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.3,,IC50,,47.0,,,,,,19950900, Leukotriene A4 hydrolase,1395,P09960,Human,compound 1a [PMID: 25692029],9091,,5478838,C[C@@H](C(=O)O)NC(=O)[C@@H](CP(=O)([C@@H](N)C)O)Cc1ccc(cc1)c1ccccc1,"InChI=1S/C21H27N2O5P/c1-14(21(25)26)23-20(24)19(13-29(27,28)15(2)22)12-16-8-10-18(11-9-16)17-6-4-3-5-7-17/h3-11,14-15,19H,12-13,22H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)/t14-,15+,19+/m0/s1",CWJPVKSBGVPXRD-QMTMVMCOSA-N,Inhibitor,Inhibition,,,,,pKi,,8.27,,Ki,,5.4,,=,,,,25692029|18804029, Leukotriene A4 hydrolase,1395,P09960,Human,SC-22716,9102,,10333202,C1CCN(C1)CCOc1ccc(cc1)c1ccccc1,"InChI=1S/C18H21NO/c1-2-6-16(7-3-1)17-8-10-18(11-9-17)20-15-14-19-12-4-5-13-19/h1-3,6-11H,4-5,12-15H2",PKUGRVAJRGZDJP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.7,,IC50,,200.0,,=,,,,10691697, Leukotriene A4 hydrolase,1395,P09960,Human,4-OMe-ARM1,10562,,145704648,COc1ccc(cc1)Cc1ccc(cc1)c1csc(n1)N,"InChI=1S/C17H16N2OS/c1-20-15-8-4-13(5-9-15)10-12-2-6-14(7-3-12)16-11-21-17(18)19-16/h2-9,11H,10H2,1H3,(H2,18,19)",GGCCOFFVKJCRKJ-UHFFFAOYSA-N,Activator,Activation,AC50= 83 nM,,,,,,,,,,,,=,,,,31751136, Leukotriene A4 hydrolase,1395,P09960,Human,LYS006,11205,,118166560,N[C@H](Cn1nnc(n1)c1ccc(cc1)Oc1ncc(cc1F)Cl)CC(=O)O,"InChI=1S/C16H14ClFN6O3/c17-10-5-13(18)16(20-7-10)27-12-3-1-9(2-4-12)15-21-23-24(22-15)8-11(19)6-14(25)26/h1-5,7,11H,6,8,19H2,(H,25,26)/t11-/m0/s1",ZEGMEJVULDALSH-NSHDSACASA-N,Inhibitor,Inhibition,,,,,pIC50,,8.7,,IC50,,2.0,,=,Inhibition of enzyme activity determined in a fluorescence assay using a 7-amino-4-methylcoumarin (AMC) arginine derivative (Arg-AMC) as a surrogate substrate for LTA4H.,,,, Leukotriene A4 hydrolase,1395,P09960,Human,kelatorphan,11656,,123982,C[C@@H](C(=O)O)NC(=O)[C@H](Cc1ccccc1)CC(=O)NO,"InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/t9-,11+/m0/s1",OJCFZTVYDSKXNM-GXSJLCMTSA-N,Inhibitor,Inhibition,,,,,pKi,,8.0,,Ki,,10.0,,=,,,,, Leukotriene A4 hydrolase,1395,P09960,Human,acebilustat,11984,,68488178,C1[C@H]2CN([C@@H]1CN2Cc1ccc(cc1)Oc1ccc(cc1)c1ncco1)Cc1ccc(cc1)C(=O)O,"InChI=1S/C29H27N3O4/c33-29(34)23-5-1-20(2-6-23)16-31-18-25-15-24(31)19-32(25)17-21-3-9-26(10-4-21)36-27-11-7-22(8-12-27)28-30-13-14-35-28/h1-14,24-25H,15-19H2,(H,33,34)/t24-,25-/m0/s1",GERJIEKMNDGSCS-DQEYMECFSA-N,Inhibitor,Inhibition,,,,,pIC50,7.22,,7.17,IC50,68.0,,60.0,=,"Inhibition of LTA4H activity by the inhibitor is measured as reduction in LTB4 production in human whole blood, by ELISA",,,,