target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id diacylglycerol lipase β,1397,Q8NCG7,Human,RHC80267,5255,,5063,O=C(ON=C1CCCCC1)NCCCCCCNC(=O)ON=C1CCCCC1,"InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)",RXSVYGIGWRDVQC-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,,,,,,,,,=,,,,, diacylglycerol lipase β,1397,Q8NCG7,Human,orlistat,5277,,3034010,CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O,"InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1",AHLBNYSZXLDEJQ-FWEHEUNISA-N,Inhibitor,Inhibition,,,,,pIC50,,7.0,,IC50,,100.0,,=,,,,14610053, diacylglycerol lipase β,1397,Q8NCG7,Human,DO34,10243,,129188708,O=C(N1CCN(C(C1)Cc1ccccc1)C(=O)n1nnc(c1)c1ccc(cc1)OC(F)(F)F)OC(C)(C)C,"InChI=1S/C26H28F3N5O4/c1-25(2,3)38-24(36)32-13-14-33(20(16-32)15-18-7-5-4-6-8-18)23(35)34-17-22(30-31-34)19-9-11-21(12-10-19)37-26(27,28)29/h4-12,17,20H,13-16H2,1-3H3",CQGMWUWJVBKTRM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.1,,,,,,=,,,,26668358, diacylglycerol lipase β,1397,Q8NCG7,Human,DH376,10244,,129188688,C#CCO[C@@H]1CC[C@@H](N(C1)C(=O)n1ncc(n1)C(c1ccc(cc1)F)(c1ccc(cc1)F)O)Cc1ccccc1,"InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1",GVLOFRPVRYAFKI-VSGBNLITSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.6,,,,,,=,,,,26668358, diacylglycerol lipase β,1397,Q8NCG7,Human,KT-109,10245,,53364540,O=C(N1CCCCC1Cc1ccccc1)n1nnc(c1)c1ccc(cc1)c1ccccc1,"InChI=1S/C27H26N4O/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2",JKJMWHULJIOKPJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.4,,IC50,,40.0,,=,Determined by competitive ABPP using the HT-01 probe for inhibition of recombinant human DAGL-β,,,23103940, diacylglycerol lipase β,1397,Q8NCG7,Human,KT-109,10245,,53364540,O=C(N1CCCCC1Cc1ccccc1)n1nnc(c1)c1ccc(cc1)c1ccccc1,"InChI=1S/C27H26N4O/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2",JKJMWHULJIOKPJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.09,,IC50,,82.0,,=,As measured by LC-MS substrate assay.,,,23103940, diacylglycerol lipase β,1397,Q8NCG7,Human,LEI105,10246,,122390213,Cc1ccc(cc1)c1cnc2c(c1)oc(n2)C(=O)CCCCCc1ccccc1,"InChI=1S/C25H24N2O2/c1-18-12-14-20(15-13-18)21-16-23-24(26-17-21)27-25(29-23)22(28)11-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,12-17H,3,6-7,10-11H2,1H3",XDHONXIOZAUYDB-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.1,,,,,,=,Inhibition of recombinant human DAGβ in a biochemical assay with para-nitrophenylbutyrate as a surrogate substrate.,,,26083464,