target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id PLA2-G7,1432,Q13093,Human,darapladib,6696,,9939609,CCN(CCN(C(=O)Cn1c(SCc2ccc(cc2)F)nc(=O)c2c1CCC2)Cc1ccc(cc1)c1ccc(cc1)C(F)(F)F)CC,"InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3",WDPFJWLDPVQCAJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,10.31,,IC50,,0.049,,=,"In a biochemical assay, measuring fluorescence intensity and using Thio-Paf.",,,27933945, PLA2-G7,1432,Q13093,Human,darapladib,6696,,9939609,CCN(CCN(C(=O)Cn1c(SCc2ccc(cc2)F)nc(=O)c2c1CCC2)Cc1ccc(cc1)c1ccc(cc1)C(F)(F)F)CC,"InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3",WDPFJWLDPVQCAJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.96,,IC50,,0.11,,=,,,,12643913, PLA2-G7,1432,Q13093,Human,darapladib,6696,,9939609,CCN(CCN(C(=O)Cn1c(SCc2ccc(cc2)F)nc(=O)c2c1CCC2)Cc1ccc(cc1)c1ccc(cc1)C(F)(F)F)CC,"InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3",WDPFJWLDPVQCAJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.46,,IC50,,35.0,,=,"In an assay using whole human plasma and recombinant hPLA2-G7, that approximates the physiological environment of the enzyme.",,,27933945, PLA2-G7,1432,Q13093,Human,rilapladib,7376,,9918381,COCCN1CCC(CC1)N(C(=O)Cn1c(SCc2cccc(c2F)F)cc(=O)c2c1cccc2)Cc1ccc(cc1)c1ccc(cc1)C(F)(F)F,"InChI=1S/C40H38F5N3O3S/c1-51-22-21-46-19-17-32(18-20-46)47(24-27-9-11-28(12-10-27)29-13-15-31(16-14-29)40(43,44)45)37(50)25-48-35-8-3-2-6-33(35)36(49)23-38(48)52-26-30-5-4-7-34(41)39(30)42/h2-16,23,32H,17-22,24-26H2,1H3",NNBGCSGCRSCFEA-UHFFFAOYSA-N,Inhibitor,Competitive,,,yes,,pIC50,,9.64,,IC50,,0.23,,=,,,,19667981, PLA2-G7,1432,Q13093,Human,(S)-23 [PMID: 27933945],9796,,122707120,N#Cc1cc(OCCN2C[C@@H](CC2=O)C2(C)CCS(=O)(=O)CC2)ccc1F,"InChI=1S/C19H23FN2O4S/c1-19(4-8-27(24,25)9-5-19)15-11-18(23)22(13-15)6-7-26-16-2-3-17(20)14(10-16)12-21/h2-3,10,15H,4-9,11,13H2,1H3/t15-/m1/s1",SYEMWCXBADSSGE-OAHLLOKOSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.49,,IC50,,32.0,,=,Recombinant hLp-PLA2 in a whole human plasma Thio-PAF assay.,,,27933945, PLA2-G7,1432,Q13093,Human,(S)-23 [PMID: 27933945],9796,,122707120,N#Cc1cc(OCCN2C[C@@H](CC2=O)C2(C)CCS(=O)(=O)CC2)ccc1F,"InChI=1S/C19H23FN2O4S/c1-19(4-8-27(24,25)9-5-19)15-11-18(23)22(13-15)6-7-26-16-2-3-17(20)14(10-16)12-21/h2-3,10,15H,4-9,11,13H2,1H3/t15-/m1/s1",SYEMWCXBADSSGE-OAHLLOKOSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.92,,IC50,,120.0,,=,Recombinant hLp-PLA2 Thio-PAF biochemical assay.,,,27933945, PLA2-G7,1432,Q13093,Human,compound 37 [PMID: 29193967],9797,,132427687,N#Cc1cc(ccc1Oc1ccc(c(c1)C(F)(F)F)Cl)NS(=O)(=O)c1ccc(cc1)N,"InChI=1S/C20H13ClF3N3O3S/c21-18-7-4-15(10-17(18)20(22,23)24)30-19-8-3-14(9-12(19)11-25)27-31(28,29)16-5-1-13(26)2-6-16/h1-10,27H,26H2",GADGQEKPNKSGMT-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.85,,IC50,,14.0,,=,,,,29193967, PLA2-G7,1432,Q13093,Human,ABX-1431,10062,,71657619,O=C(N1CCN(CC1)Cc1ccc(cc1N1CCCC1)C(F)(F)F)OC(C(F)(F)F)C(F)(F)F,"InChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2",SQZJGTOZFRNWCX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.0,,IC50,,10000.0,,>,,,,30067909,