target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id protein kinase C theta,1488,Q04759,Human,GSK690693,5196,,16725726,CCn1c(nc2c1c(OC[C@H]1CCCNC1)cnc2C#CC(O)(C)C)c1nonc1N,"InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1",KGPGFQWBCSZGEL-ZDUSSCGKSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.7,,IC50,,2.0,,=,,,,18800763, protein kinase C theta,1488,Q04759,Human,sotrastaurin,7946,,10296883,CN1CCN(CC1)c1nc2ccccc2c(n1)C1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2,"InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)",OAVGBZOFDPFGPJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.0,,IC50,,1.0,,=,,,,19827831, protein kinase C theta,1488,Q04759,Human,compound 41 [PMID: 25000588],9349,,76285722,O=C1NN=C2N([C@@H]1C)c1cc(NC3(C)CNC3)c(cc1OC2)C(F)(F)F,"InChI=1S/C16H18F3N5O2/c1-8-14(25)23-22-13-5-26-12-3-9(16(17,18)19)10(4-11(12)24(8)13)21-15(2)6-20-7-15/h3-4,8,20-21H,5-7H2,1-2H3,(H,23,25)/t8-/m1/s1",OUZPGLCFBNPQPF-MRVPVSSYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.64,,IC50,,23.0,,=,In a biochemical enzyme activity assay,,,25000588, protein kinase C theta,1488,Q04759,Human,PKCθ inhibitor 14,9452,,91933875,O=C1NC(C)(C)N(c2c1ccc(c2)n1c(=O)[nH]c2c1cccn2)[C@@H](c1ccccc1)C,"InChI=1S/C24H23N5O2/c1-15(16-8-5-4-6-9-16)29-20-14-17(11-12-18(20)22(30)27-24(29,2)3)28-19-10-7-13-25-21(19)26-23(28)31/h4-15H,1-3H3,(H,27,30)(H,25,26,31)/t15-/m1/s1",WNYKGJHEQVIFGL-OAHLLOKOSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.6,,IC50,,0.25,,=,In a biochemical assay.,,,27117263, protein kinase C theta,1488,Q04759,Human,darovasertib,11186,,118873253,O=C(c1nc(cnc1N)c1ncccc1C(F)(F)F)Nc1ncccc1N1CCC(CC1)(C)N,"InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34)",XXJXHXJWQSCNPX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.4,,IC50,,0.4,,=,,,,, protein kinase C theta,1488,Q04759,Human,CC-90005,11659,,118162109,CC(F)(F)COc1c(CNc2nc(N[C@@H]3CC[C@H](O)C(C)(C)C3)c(cn2)C#N)cncn1,"InChI=1S/C21H27F2N7O2/c1-20(2)6-15(4-5-16(20)31)29-17-13(7-24)9-26-19(30-17)27-10-14-8-25-12-28-18(14)32-11-21(3,22)23/h8-9,12,15-16,31H,4-6,10-11H2,1-3H3,(H2,26,27,29,30)/t15-,16+/m1/s1",FMKGJQHNYMWDFJ-CVEARBPZSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.1,,IC50,,8.0,,=,,,,34355886, protein kinase C theta,1488,Q04759,Human,aplithianine A,13089,,168665407,CN1C=NC=C1C2=CN(CCS2)C3=NC=NC4=C3NC=N4,"InChI=1S/C13H13N7S/c1-19-8-14-4-9(19)10-5-20(2-3-21-10)13-11-12(16-6-15-11)17-7-18-13/h4-8H,2-3H2,1H3,(H,15,16,17,18)",IEDDDZFQZKDRBJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.44,,IC50,,36.0,,=,,,,37843072,