target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id TLR8,1758,Q9NR97,Human,motolimod,9026,,16049404,CCCN(C(=O)C1=Cc2ccc(cc2N=C(C1)N)c1ccc(cc1)C(=O)N1CCCC1)CCC,"InChI=1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-18H,3-6,13-16,19H2,1-2H3,(H2,29,30)",QSPOQCXMGPDIHI-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,7.0,,EC50,,100.0,,~,,,,22128302, TLR8,1758,Q9NR97,Human,3M-002,9270,,10198719,CCCc1nc2c(s1)c1ccccc1nc2N,"InChI=1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)",NFYMGJSUKCDVJR-UHFFFAOYSA-N,Agonist,Agonist,,,yes,,pEC50,,5.88,,EC50,,1320.0,,=,Assessed as ability to activate NF-κB in HEK293 cells expressing human TLR8.,,,22924757, TLR8,1758,Q9NR97,Human,"compound 12p [Larson et al., 2017]",9690,,130276131,NCCn1c(CCCC)nc2c1c1ccc(cc1nc2N)C(=O)OC,"InChI=1S/C18H23N5O2/c1-3-4-5-14-22-15-16(23(14)9-8-19)12-7-6-11(18(24)25-2)10-13(12)21-17(15)20/h6-7,10H,3-5,8-9,19H2,1-2H3,(H2,20,21)",ZYCFMHCDZSVIGF-UHFFFAOYSA-N,Agonist,Agonist,,,yes,,pEC50,,5.3,,EC50,,4980.0,,=,,,,29152046, TLR8,1758,Q9NR97,Human,CU-CPT8m,9795,,15042086,Cc1cccc(c1)c1ccnc2n1ncc2C(=O)N,"InChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19)",HNKGGVGQAVODNJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.17,,IC50,,67.0,,=,,,,29155428, TLR8,1758,Q9NR97,Human,CU-CPT8m,9795,,15042086,Cc1cccc(c1)c1ccnc2n1ncc2C(=O)N,"InChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19)",HNKGGVGQAVODNJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,6.66,,Kd,,220.0,,=,Dissociation constant measured using isothermal titration calorimetry (ITC) and the hTRL8 ectodomain.,,,29155428, TLR8,1758,Q9NR97,Human,selgantolimod,10889,,122585078,CCCC[C@@](Nc1nc(N)nc2c1ncc(c2)F)(CO)C,"InChI=1S/C14H20FN5O/c1-3-4-5-14(2,8-21)20-12-11-10(18-13(16)19-12)6-9(15)7-17-11/h6-7,21H,3-5,8H2,1-2H3,(H3,16,18,19,20)/t14-/m1/s1",HTCJUBZBSJQWBW-CQSZACIVSA-N,Agonist,Agonist,,,,,pEC50,,6.66,,EC50,,220.0,,=,,,,32407112, TLR8,1758,Q9NR97,Human,compound 15 [PMID: 35450354],11989,,163358783,C1(CC1)c1cc2c(n[nH]c2cc1c1cc(nc(c1)C)C)N[C@H]1[C@@H](CN(CC1)C)F,"InChI=1S/C23H28FN5/c1-13-8-16(9-14(2)25-13)18-11-22-19(10-17(18)15-4-5-15)23(28-27-22)26-21-6-7-29(3)12-20(21)24/h8-11,15,20-21H,4-7,12H2,1-3H3,(H2,26,27,28)/t20-,21-/m1/s1",PNGWZDXPZBZBRC-NHCUHLMSSA-N,Antagonist,Antagonist,,,,,pIC50,,8.7,,IC50,,2.0,,=,Binding determined in a FRET assay,,,35450354,