target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id cyclin dependent kinase 2,1973,P24941,Human,AT-7519,5662,,11338033,O=C(c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl)NC1CCNCC1,"InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)",OVPNQJVDAFNBDN-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.33,,IC50,,47.0,,=,,,,19174555, cyclin dependent kinase 2,1973,P24941,Human,AT-7519,5662,,11338033,O=C(c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl)NC1CCNCC1,"InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)",OVPNQJVDAFNBDN-UHFFFAOYSA-N,Inhibitor,None,,,,,pKd,,7.52,,Kd,,30.0,,=,,,,22037378, cyclin dependent kinase 2,1973,P24941,Human,BMS-387032,5670,,3025986,O=C(C1CCNCC1)Nc1ncc(s1)SCc1ncc(o1)C(C)(C)C,"InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)",OUSFTKFNBAZUKL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,7.16,,Kd,,69.0,,=,,,,22037378, cyclin dependent kinase 2,1973,P24941,Human,BMS-387032,5670,,3025986,O=C(C1CCNCC1)Nc1ncc(s1)SCc1ncc(o1)C(C)(C)C,"InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)",OUSFTKFNBAZUKL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,7.42,,Ki,,38.0,,=,,,,23252711, cyclin dependent kinase 2,1973,P24941,Human,alvocidib,5680,,5287969,CN1CC[C@@H]([C@@H](C1)O)c1c(O)cc(c2c1oc(cc2=O)c1ccccc1Cl)O,"InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1",BIIVYFLTOXDAOV-YVEFUNNKSA-N,Inhibitor,Inhibition,,,yes,,pIC50,7.0,,6.4,IC50,400.0,,100.0,=,,,,8674031|8002990, cyclin dependent kinase 2,1973,P24941,Human,R547,5707,,6918852,COc1ccc(c(c1C(=O)c1cnc(nc1N)NC1CCN(CC1)S(=O)(=O)C)F)F,"InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24)",JRNJNYBQQYBCLE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKd,,9.28,,Kd,,0.53,,=,,,,22037378, cyclin dependent kinase 2,1973,P24941,Human,R547,5707,,6918852,COc1ccc(c(c1C(=O)c1cnc(nc1N)NC1CCN(CC1)S(=O)(=O)C)F)F,"InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24)",JRNJNYBQQYBCLE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,8.52,,Ki,,3.0,,=,Assayed using CDK2/cyclin E complex.,,,17121911, cyclin dependent kinase 2,1973,P24941,Human,aloisine,5923,,3641059,CCCCc1c([nH]c2c1nccn2)c1ccc(cc1)OC,"InChI=1S/C17H19N3O/c1-3-4-5-14-15(12-6-8-13(21-2)9-7-12)20-17-16(14)18-10-11-19-17/h6-11H,3-5H2,1-2H3,(H,19,20)",WVMANZPBOBRWCB-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,9.28,,Ki,,0.53,,=,Measuring inhibition of CDK2 in association with cyclin E,,,22289061, cyclin dependent kinase 2,1973,P24941,Human,aloisine A,5924,,448912,CCCCc1c(=C2C=CC(=O)C=C2)[nH]c2c1[nH]ccn2,"InChI=1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,17H,2-4H2,1H3,(H,18,19)",AYIIQABSVDIZSY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.92,,IC50,,120.0,,=,CDK2 in association with cyclin A,,,12519061, cyclin dependent kinase 2,1973,P24941,Human,aminopurvalanol A,5927,,6604931,OC[C@@H](C(C)C)Nc1nc(Nc2cc(N)cc(c2)Cl)c2c(n1)n(cn2)C(C)C,"InChI=1S/C19H26ClN7O/c1-10(2)15(8-28)24-19-25-17(23-14-6-12(20)5-13(21)7-14)16-18(26-19)27(9-22-16)11(3)4/h5-7,9-11,15,28H,8,21H2,1-4H3,(H2,23,24,25,26)/t15-/m0/s1",RAMROQQYRRQPDL-HNNXBMFYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.55,,IC50,,28.0,,=,CDK2 in association with cyclin E,,,18077363, cyclin dependent kinase 2,1973,P24941,Human,JNJ-7706621,5932,,5330790,Fc1cccc(c1C(=O)n1nc(nc1N)Nc1ccc(cc1)S(=O)(=O)N)F,"InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)",KDKUVYLMPJIGKA-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.7,,IC50,,2.0,,=,CDK2 in association with cyclin A,,,15974571, cyclin dependent kinase 2,1973,P24941,Human,bohemine,5938,,2422,OCCCNc1nc(NCc2ccccc2)c2c(n1)n(cn2)C(C)C,"InChI=1S/C18H24N6O/c1-13(2)24-12-21-15-16(20-11-14-7-4-3-5-8-14)22-18(23-17(15)24)19-9-6-10-25/h3-5,7-8,12-13,25H,6,9-11H2,1-2H3,(H2,19,20,22,23)",OPQGFIAVPSXOBO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.22,,IC50,,600.0,,=,CDK2/cyclin E complexes purified from sf9 cells.,,,11896531, cyclin dependent kinase 2,1973,P24941,Human,CGP74514A,5945,,2794188,CCn1cnc2c1nc(N[C@@H]1CCCC[C@@H]1N)nc2Nc1cccc(c1)Cl,"InChI=1S/C19H24ClN7/c1-2-27-11-22-16-17(23-13-7-5-6-12(20)10-13)25-19(26-18(16)27)24-15-9-4-3-8-14(15)21/h5-7,10-11,14-15H,2-4,8-9,21H2,1H3,(H2,23,24,25,26)/t14-,15+/m0/s1",UTBSBSOBZHXMHI-LSDHHAIUSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.59,,IC50,,26.0,,=,In vitro inhibition of human CDK2/cyclin E.,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,CGP74514A,5945,,2794188,CCn1cnc2c1nc(N[C@@H]1CCCC[C@@H]1N)nc2Nc1cccc(c1)Cl,"InChI=1S/C19H24ClN7/c1-2-27-11-22-16-17(23-13-7-5-6-12(20)10-13)25-19(26-18(16)27)24-15-9-4-3-8-14(15)21/h5-7,10-11,14-15H,2-4,8-9,21H2,1H3,(H2,23,24,25,26)/t14-,15+/m0/s1",UTBSBSOBZHXMHI-LSDHHAIUSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.34,,IC50,,46.0,,=,In vitro inhibition of human CDK2/cyclin A.,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,Cdk1/2 inhibitor III,5946,,5330812,Fc1cccc(c1NC(=S)n1nc(nc1N)Nc1ccc(cc1)S(=O)(=O)N)F,"InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)",ARIOBGGRZJITQX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.3,,IC50,,0.5,,=,CDK2/cyclin A complex,,,15974571, cyclin dependent kinase 2,1973,P24941,Human,Cdk2 inhibitor III,5948,,6918386,OCCN(c1nc(NCc2ccc(cc2)OC)c2c(n1)n(cn2)C(C)C)CCO,"InChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)",NQVIIUBWMBHLOZ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.3,,IC50,,500.0,,=,CDK2/cyclin E complex,,,, cyclin dependent kinase 2,1973,P24941,Human,Cdk2 inhibitor IV,5949,,10202471,CCN(C(=O)c1ccc(cc1)Nc1nc(OCC2CCCCC2)c2c(n1)nc[nH]2)CC,"InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)",XHEQSRJCJTWWAH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.4,,IC50,,400.0,,=,,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,Cdk2 inhibitor IV,5949,,10202471,CCN(C(=O)c1ccc(cc1)Nc1nc(OCC2CCCCC2)c2c(n1)nc[nH]2)CC,"InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)",XHEQSRJCJTWWAH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.39,,IC50,,410.0,,=,CDK2/cyclin A complex used in assay,,,16170024, cyclin dependent kinase 2,1973,P24941,Human,Cdk4 inhibitor,5950,,5330797,Brc1ccc2c(c1)[nH]c1c2c2c(=O)[nH]c(=O)c2c2c1[nH]c1c2cccc1,"InChI=1S/C20H10BrN3O2/c21-8-5-6-10-12(7-8)23-18-14(10)16-15(19(25)24-20(16)26)13-9-3-1-2-4-11(9)22-17(13)18/h1-7,22-23H,(H,24,25,26)",NMFKDDRQSNVETB-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.28,,IC50,,520.0,,=,CDK2/cyclin E complex,,,12747775, cyclin dependent kinase 2,1973,P24941,Human,Cdk4 inhibitor II,5951,,3004085,COc1ccc(c2c1[nH]c1ccccc1c2=S)OC,"InChI=1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)",KFAKESMKRPNZTM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,4.0,,IC50,,100000.0,,>,CDK2/cyclin A complex used in assay,,,10632371, cyclin dependent kinase 2,1973,P24941,Human,Cdk4 inhibitor III,5952,,481747,Cc1ccc(cc1)NC1=CC(=O)c2c(C1=O)nc(s2)C,"InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3",HFPLHASLIOXVGS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.7,,IC50,,200.0,,>,CDK2/cyclin A complex,,,10743948, cyclin dependent kinase 2,1973,,spiny starfish,kenpaullone,6000,,3820,O=C1Nc2ccccc2c2c(C1)c1cc(Br)ccc1[nH]2,"InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)",QQUXFYAWXPMDOE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.17,,IC50,,680.0,,=,CDK2/cyclin A complex,,,10363974, cyclin dependent kinase 2,1973,P24941,Human,purvalanol A,6030,,4987,OCC(C(C)C)Nc1nc(Nc2cccc(c2)Cl)c2c(n1)n(cn2)C(C)C,"InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)",PMXCMJLOPOFPBT-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.46,,IC50,,35.0,,=,CDK2/cyclin E complex used in assay,,,9677190, cyclin dependent kinase 2,1973,P24941,Human,seliciclib,6035,,160355,CC[C@@H](Nc1nc(NCc2ccccc2)c2c(n1)n(cn2)C(C)C)CO,"InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1",BTIHMVBBUGXLCJ-OAHLLOKOSA-N,Inhibitor,Inhibition,,,yes,,pKi,,6.6,,Ki,,250.0,,=,CDK2/cyclin A complex used in assay,,,23252711, cyclin dependent kinase 2,1973,P24941,Human,SU9516,6045,,5289419,COc1ccc2c(c1)/C(=C/c1cnc[nH]1)/C(=O)N2,"InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)/b11-4-",QNUKRWAIZMBVCU-WCIBSUBMSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.66,,IC50,,22.0,,=,CDK2/cyclin A complex used in assay,,,11507069, cyclin dependent kinase 2,1973,P24941,Human,SU9516,6045,,5289419,COc1ccc2c(c1)/C(=C/c1cnc[nH]1)/C(=O)N2,"InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)/b11-4-",QNUKRWAIZMBVCU-WCIBSUBMSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.59,,IC50,,26.0,,=,In vitro inhibition of CDK2/cyclin E.,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,SU9516,6045,,5289419,COc1ccc2c(c1)/C(=C/c1cnc[nH]1)/C(=O)N2,"InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)/b11-4-",QNUKRWAIZMBVCU-WCIBSUBMSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.57,,IC50,,27.0,,=,In vitro inhibition of CDK2/cyclin A.,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,dinaciclib,7379,,46926350,OCC[C@@H]1CCCCN1c1cc(NCc2ccc[n+](c2)[O-])n2c(n1)c(CC)cn2,"InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1",PIMQWRZWLQKKBJ-SFHVURJKSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.0,,IC50,,1.0,,=,,,,24007471, cyclin dependent kinase 2,1973,P24941,Human,dinaciclib,7379,,46926350,OCC[C@@H]1CCCCN1c1cc(NCc2ccc[n+](c2)[O-])n2c(n1)c(CC)cn2,"InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1",PIMQWRZWLQKKBJ-SFHVURJKSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.7,,IC50,,2.0,,=,Inhibition of CDK2/cyclin E complex.,,,30943029, cyclin dependent kinase 2,1973,P24941,Human,RGB-286638,7744,,11285002,COCCN1CCN(CC1)Cc1ccc(cc1)c1n[nH]c2c1C(=O)c1c2cccc1NC(=O)NN1CCOCC1,"InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)",XLSYZSRXVVCHLS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.52,,IC50,,3.0,,=,in association with cyclin E,,,23807770, cyclin dependent kinase 2,1973,P24941,Human,purvalanol B,7806,,448991,OC[C@@H](C(C)C)Nc1nc(Nc2ccc(c(c2)Cl)C(=O)O)c2c(n1)n(cn2)C(C)C,"InChI=1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1",ZKDXRFMOHZVXSG-HNNXBMFYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.22,,IC50,,6.0,,=,CDK2/cyclin A complex used in assay,,,9677190, cyclin dependent kinase 2,1973,P24941,Human,roniciclib,7874,,45380979,C[C@H]([C@H](Oc1nc(ncc1C(F)(F)F)Nc1ccc(cc1)S(=O)(=N)C1CC1)C)O,"InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1",UELYDGOOJPRWGF-MFOHZAOFSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.05,,IC50,,9.0,,=,CDK2/cyclin E complex,,,23671017, cyclin dependent kinase 2,1973,P24941,Human,milciclib,7938,,16718576,CNC(=O)c1nn(c2c1C(C)(C)Cc1c2nc(nc1)Nc1ccc(cc1)N1CCN(CC1)C)C,"InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)",RXZMYLDMFYNEIM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.35,,IC50,,45.0,,=,CDK2/cyclin A complex,,,19603809, cyclin dependent kinase 2,1973,P24941,Human,milciclib,7938,,16718576,CNC(=O)c1nn(c2c1C(C)(C)Cc1c2nc(nc1)Nc1ccc(cc1)N1CCN(CC1)C)C,"InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)",RXZMYLDMFYNEIM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.96,,IC50,,109.0,,=,In vitro inhibition of CDK2/cyclin A.,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,milciclib,7938,,16718576,CNC(=O)c1nn(c2c1C(C)(C)Cc1c2nc(nc1)Nc1ccc(cc1)N1CCN(CC1)C)C,"InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)",RXZMYLDMFYNEIM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.23,,IC50,,590.0,,=,In vitro inhibition of CDK2/cyclin E.,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,MK-8776,7943,,16224745,Cn1ncc(c1)c1cnn2c1nc(C1CCCNC1)c(c2N)Br,"InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3",GMIZZEXBPRLVIV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.8,,IC50,,160.0,,=,CDK2/cyclin A complex in assay,,,21094607, cyclin dependent kinase 2,1973,P24941,Human,BX-795,8006,,10077147,O=C(N1CCCC1)Nc1cccc(c1)Nc1ncc(c(n1)NCCCNC(=O)c1cccs1)I,"InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)",VAVXGGRQQJZYBL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.37,,IC50,,430.0,,=,,,,15772071, cyclin dependent kinase 2,1973,P24941,Human,BX-912,8007,,11754511,O=C(N1CCCC1)Nc1cccc(c1)Nc1ncc(c(n1)NCCc1cnc[nH]1)Br,"InChI=1S/C20H23BrN8O/c21-17-12-24-19(28-18(17)23-7-6-16-11-22-13-25-16)26-14-4-3-5-15(10-14)27-20(30)29-8-1-2-9-29/h3-5,10-13H,1-2,6-9H2,(H,22,25)(H,27,30)(H2,23,24,26,28)",DMMILYKXNCVKOJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.19,,IC50,,650.0,,=,,,,15772071, cyclin dependent kinase 2,1973,P24941,Human,BMS-265246,8051,,5329775,CCCCOc1c(cnc2c1cn[nH]2)C(=O)c1c(F)cc(cc1F)C,"InChI=1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23)",SCFMWQIQBVZOQR-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.05,,IC50,,9.0,,=,,,,21216932, cyclin dependent kinase 2,1973,P24941,Human,compound 89S [PMID: 19115845],8114,,16757525,FCC[C@H]1CNC(=O)c2c1[nH]c(c2)c1ccnc(n1)N,"InChI=1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m0/s1",LCBAQTCTQXHTJG-ZETCQYMHSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.86,,IC50,,138.0,,=,CDK2/cyclin A complex,,,19115845, cyclin dependent kinase 2,1973,P24941,Human,compound 9b [PMID: 18986805],8160,,11675054,CNC(=O)c1ccc(cc1F)Nc1nccc(n1)c1cnc(n1C(C)C)C,"InChI=1S/C19H21FN6O/c1-11(2)26-12(3)23-10-17(26)16-7-8-22-19(25-16)24-13-5-6-14(15(20)9-13)18(27)21-4/h5-11H,1-4H3,(H,21,27)(H,22,24,25)",OCUYCOQPRGFQEV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.0,,IC50,,1.0,,<,,,,18986805, cyclin dependent kinase 2,1973,P24941,Human,BS-194,8176,,25125014,OC[C@@H]([C@@H](CO)O)Nc1cc(NCc2ccccc2)n2c(n1)c(cn2)C(C)C,"InChI=1S/C20H27N5O3/c1-13(2)15-10-22-25-19(21-9-14-6-4-3-5-7-14)8-18(24-20(15)25)23-16(11-26)17(28)12-27/h3-8,10,13,16-17,21,26-28H,9,11-12H2,1-2H3,(H,23,24)/t16-,17+/m0/s1",KRIWIRSMQRQYJG-DLBZAZTESA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.52,,IC50,,3.0,,=,,,,21080703, cyclin dependent kinase 2,1973,P24941,Human,compound 3 [PMID: 19097791],8185,,135928471,COc1cc(ccc1O)c1ccc2c(c1)[nH]nc2c1nc2c([nH]1)cccc2N1CCN(CC1)C,"InChI=1S/C26H26N6O2/c1-31-10-12-32(13-11-31)21-5-3-4-19-25(21)28-26(27-19)24-18-8-6-16(14-20(18)29-30-24)17-7-9-22(33)23(15-17)34-2/h3-9,14-15,33H,10-13H2,1-2H3,(H,27,28)(H,29,30)",KKMLIJHOUUKCSW-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.39,,IC50,,4.1,,=,,,,19097791, cyclin dependent kinase 2,1973,P24941,Human,AZD5438,8473,,16747683,CC(n1c(C)ncc1c1ccnc(n1)Nc1ccc(cc1)S(=O)(=O)C)C,"InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22)",WJRRGYBTGDJBFX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.22,,IC50,,6.0,,=,CDK2/cyclin E complex.,,,19509270, cyclin dependent kinase 2,1973,P24941,Human,zotiraciclib,9095,,16739650,CN1C/C=C/CCOc2cccc(c2)c2nc(Nc3cc(C1)ccc3)ncc2,"InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+",VXBAJLGYBMTJCY-NSCUHMNNSA-N,Inhibitor,Inhibition,,,,,pIC50,8.3,,7.89,IC50,13.0,,5.0,=,,,,22148278|21860433, cyclin dependent kinase 2,1973,P24941,Human,VTX-11e,9375,,11634725,OC[C@H](c1cccc(c1)Cl)NC(=O)c1[nH]cc(c1)c1nc(ncc1C)Nc1ccc(cc1Cl)F,"InChI=1S/C24H20Cl2FN5O2/c1-13-10-29-24(31-19-6-5-17(27)9-18(19)26)32-22(13)15-8-20(28-11-15)23(34)30-21(12-33)14-3-2-4-16(25)7-14/h2-11,21,28,33H,12H2,1H3,(H,30,34)(H,29,31,32)/t21-/m1/s1",WUTVMXLIGHTZJC-OAQYLSRUSA-N,Inhibitor,Inhibition,,,,,pKi,,6.07,,Ki,,852.0,,=,,,,19827834, cyclin dependent kinase 2,1973,P24941,Human,BS-181,9405,,49867929,NCCCCCCNc1cc(NCc2ccccc2)n2c(n1)c(cn2)C(C)C,"InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27)",DNYBIOICMDTDAP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.06,,IC50,,880.0,,=,Evaluated using purified recombinant CDK2/cycE complex and measuring free ATP remaining in the reaction using a luciferase assay.,,,19638587, cyclin dependent kinase 2,1973,P24941,Human,trilaciclib,9626,,68029831,CN1CCN(CC1)c1ccc(nc1)Nc1ncc2c(n1)n1c(c2)C(=O)NCC21CCCCC2,"InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29)",PDGKHKMBHVFCMG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.89,,IC50,,1290.0,,=,Inhibition of CDK2/cyclinA,,,26826116, cyclin dependent kinase 2,1973,P24941,Human,samuraciclib,9903,,91844733,O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccccc2)n2c(n1)c(cn2)C(C)C,"InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1",YCVGLKWJKIKVBI-MJGOQNOKSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.21,,IC50,,620.0,,=,In a biochemical assay.,,,29545334, cyclin dependent kinase 2,1973,P24941,Human,voruciclib,9923,,67409219,OC[C@@H]1N(C)CC[C@H]1c1c(O)cc(c2c1oc(cc2=O)c1ccc(cc1Cl)C(F)(F)F)O,"InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1",MRPGRAKIAJJGMM-OCCSQVGLSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.74,,IC50,,180.0,,=,Inhibition of CDK2/cyclinA,,,26606677, cyclin dependent kinase 2,1973,P24941,Human,kinase inhibitor 2 [PMID: 30199702],10081,,134813913,N[C@@H]1CC[C@H](CC1)Nc1nc(NCc2ccc(cc2)c2ccccn2)n2c(n1)c(cn2)C(C)C,"InChI=1S/C26H32N8/c1-17(2)22-16-30-34-24(22)32-25(31-21-12-10-20(27)11-13-21)33-26(34)29-15-18-6-8-19(9-7-18)23-5-3-4-14-28-23/h3-9,14,16-17,20-21H,10-13,15,27H2,1-2H3,(H2,29,31,32,33)/t20-,21-",PRJNNPMIUGYOST-MEMLXQNLSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.17,,IC50,,68.0,,=,CDK2/cyclin A,,,30199702, cyclin dependent kinase 2,1973,P24941,Human,RO3306,10095,,136240579,O=C1N=C(SC1=Cc1ccc2c(c1)cccn2)NCc1cccs1,"InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)",XOLMRFUGOINFDQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.73,,IC50,,186.0,,=,In vitro inhibition of human CDK2/cyclin E.,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,RO3306,10095,,136240579,O=C1N=C(SC1=Cc1ccc2c(c1)cccn2)NCc1cccs1,"InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)",XOLMRFUGOINFDQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.6,,IC50,,253.0,,=,In vitro inhibition of human CDK2/cyclin A.,,,30234987, cyclin dependent kinase 2,1973,P24941,Human,CDK inhibitor 4.35,10357,,138105941,NCCSc1nc(NCc2ccc(cc2)c2ccccn2)c2c(n1)c(n[nH]2)C(C)C,"InChI=1S/C22H25N7S/c1-14(2)18-19-20(29-28-18)21(27-22(26-19)30-12-10-23)25-13-15-6-8-16(9-7-15)17-5-3-4-11-24-17/h3-9,11,14H,10,12-13,23H2,1-2H3,(H,28,29)(H,25,26,27)",PCQPAKMJSYGXRE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.7,,IC50,,2.0,,=,Inhibition of CDK2/cyclin E1 complex.,,,30943029, cyclin dependent kinase 2,1973,P24941,Human,CDK inhibitor 4.35,10357,,138105941,NCCSc1nc(NCc2ccc(cc2)c2ccccn2)c2c(n1)c(n[nH]2)C(C)C,"InChI=1S/C22H25N7S/c1-14(2)18-19-20(29-28-18)21(27-22(26-19)30-12-10-23)25-13-15-6-8-16(9-7-15)17-5-3-4-11-24-17/h3-9,11,14H,10,12-13,23H2,1-2H3,(H,28,29)(H,25,26,27)",PCQPAKMJSYGXRE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.22,,IC50,,6.0,,=,Inhibition of CDK2/cyclin A2 complex.,,,30943029, cyclin dependent kinase 2,1973,P24941,Human,PF-06873600,10426,,134247638,FC(c1cc2cnc(nc2n(c1=O)[C@@H]1CCC[C@@]1(C)O)NC1CCN(CC1)S(=O)(=O)C)F,"InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1",QIEKHLDZKRQLLN-FOIQADDNSA-N,Inhibitor,Inhibition,,,,,pKi,,9.92,,Ki,,0.12,,=,Evaluated in a CDK2/Cyclin E1 mobility shift assay.,,,, cyclin dependent kinase 2,1973,P24941,Human,fadraciclib,10461,,24983461,CC[C@@H]([C@H](O)C)Nc1nc(NCc2cnc(cc2C)C)c2c(n1)n(cn2)C(C)C,"InChI=1S/C21H31N7O/c1-7-17(15(6)29)25-21-26-19(18-20(27-21)28(11-24-18)12(2)3)23-10-16-9-22-14(5)8-13(16)4/h8-9,11-12,15,17,29H,7,10H2,1-6H3,(H2,23,25,26,27)/t15-,17+/m1/s1",DLPIYBKBHMZCJI-WBVHZDCISA-N,Inhibitor,Inhibition,,,,,pIC50,,7.7,,IC50,,20.0,,=,Inhibition of CDK2/cyclin E,,,, cyclin dependent kinase 2,1973,P24941,Human,fadraciclib,10461,,24983461,CC[C@@H]([C@H](O)C)Nc1nc(NCc2cnc(cc2C)C)c2c(n1)n(cn2)C(C)C,"InChI=1S/C21H31N7O/c1-7-17(15(6)29)25-21-26-19(18-20(27-21)28(11-24-18)12(2)3)23-10-16-9-22-14(5)8-13(16)4/h8-9,11-12,15,17,29H,7,10H2,1-6H3,(H2,23,25,26,27)/t15-,17+/m1/s1",DLPIYBKBHMZCJI-WBVHZDCISA-N,Inhibitor,Inhibition,,,,,pIC50,,7.05,,IC50,,90.0,,=,Inhibition of CDK2/cyclin A,,,, cyclin dependent kinase 2,1973,P24941,Human,THAL-SNS-032,10547,,131801483,O=C(CN1CCC(CC1)C(=O)Nc1ncc(s1)SCc1ncc(o1)C(C)(C)C)NCCOCCOCCOCCNc1cccc2c1C(=O)N(C2=O)C1CCC(=O)NC1=O,"InChI=1S/C40H52N8O10S2/c1-40(2,3)29-21-43-32(58-29)24-59-33-22-44-39(60-33)46-35(51)25-9-13-47(14-10-25)23-31(50)42-12-16-56-18-20-57-19-17-55-15-11-41-27-6-4-5-26-34(27)38(54)48(37(26)53)28-7-8-30(49)45-36(28)52/h4-6,21-22,25,28,41H,7-20,23-24H2,1-3H3,(H,42,50)(H,44,46,51)(H,45,49,52)",BXDZOYLPNAIDOC-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.21,,IC50,,62.0,,=,Biochemical inhibition of CDK2/cyclin A,,,29251720, cyclin dependent kinase 2,1973,P24941,Human,tagtociclib,11525,,154616422,COCc1nn(c(c1)C(=O)Nc1n[nH]c(c1)[C@H]1CC[C@H](C1)OC(=O)NC(C)C)C,"InChI=1S/C19H28N6O4/c1-11(2)20-19(27)29-14-6-5-12(7-14)15-9-17(23-22-15)21-18(26)16-8-13(10-28-4)24-25(16)3/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,20,27)(H2,21,22,23,26)/t12-,14+/m0/s1",MTNBRBDFNSGQKB-GXTWGEPZSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.94,,IC50,,1.16,,=,Inhibition of CDK2/Cyclin E,,,35485642, cyclin dependent kinase 2,1973,P24941,Human,tanuxiciclib,11885,,137150090,Nc1nccc(c1F)c1nc(c(cc1)O)c1nc(nc(c1)C)N,"InChI=1S/C15H13FN6O/c1-7-6-10(22-15(18)20-7)13-11(23)3-2-9(21-13)8-4-5-19-14(17)12(8)16/h2-6,23H,1H3,(H2,17,19)(H2,18,20,22)",UQHDKUFLWKTTDL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.05,,IC50,,0.9,,=,CDK2/cyclinE,,,, cyclin dependent kinase 2,1973,P24941,Human,asnuciclib,12074,,71561915,Cc1c(sc(n1)NC)c1nc(ncc1F)Nc1cc(ccc1)S(=O)(=O)N,"InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22)",GAIOPWBQKZMUNO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,8.52,,Ki,,3.0,,=,Inhibition of human recombinant His6 tagged CDK2/Cyclin A expressed in Sf21 insect cells,,,23301767, cyclin dependent kinase 2,1973,P24941,Human,compound 5g [PMID: 36385925],12277,,155409732,O[C@H]1C[C@@H](CCC1)N1C(=O)C2(c3c1nc(nc3)Nc1ccc(cc1)S(=O)(=O)NC([2H])([2H])[2H])CC2,"InChI=1S/C21H25N5O4S/c1-22-31(29,30)16-7-5-13(6-8-16)24-20-23-12-17-18(25-20)26(19(28)21(17)9-10-21)14-3-2-4-15(27)11-14/h5-8,12,14-15,22,27H,2-4,9-11H2,1H3,(H,23,24,25)/t14-,15-/m1/s1/i1D3",AKQOBHZKBDHWQI-BZEFIUHZSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.59,,IC50,,2.6,,=,,,,36385925, cyclin dependent kinase 2,1973,P24941,Human,QR-6401,12511,,167993648,CC(C)(C)N1N=C2C=C1NC3=CC=CC(CO[C@H]4C[C@@H](C4)NC(=O)C[C@@H]5CC[C@H]2C5)=N3,"InChI=1S/C24H33N5O2/c1-24(2,3)29-22-13-20(28-29)16-8-7-15(9-16)10-23(30)26-18-11-19(12-18)31-14-17-5-4-6-21(25-17)27-22/h4-6,13,15-16,18-19H,7-12,14H2,1-3H3,(H,25,27)(H,26,30)/t15-,16+,18-,19-/m1/s1",MMTJVNRCAAQTPS-UKBAYJJMSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.43,,IC50,,0.37,,=,Inhibition of CDK2/cyclin E1,,,36923916, cyclin dependent kinase 2,1973,P24941,Human,KB-0742,13068,,146502834,CCC(CC)C1=NC2=CC=NN2C(=C1)N[C@H]3CC[C@@H](C3)N,"InChI=1S/C16H25N5/c1-3-11(4-2)14-10-16(19-13-6-5-12(17)9-13)21-15(20-14)7-8-18-21/h7-8,10-13,19H,3-6,9,17H2,1-2H3/t12-,13-/m0/s1",VYKCLMALANGCDF-STQMWFEESA-N,Inhibitor,Inhibition,,,,,pIC50,,6.4,,IC50,,397.0,,=,Inhibition of CDK2/Cyclin A,,,37967851,