target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id mitogen-activated protein kinase kinase 4,2065,P45985,Human,staurosporine,346,,44259,CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O,"InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1",HKSZLNNOFSGOKW-FYTWVXJKSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.0,,IC50,,1.0,,<,,,,12166950, mitogen-activated protein kinase kinase 4,2065,P45985,Human,MEK inhibitor I,6006,,9951490,N#C/C(=C(\Sc1ccccc1N)/N)/c1cccc(c1)C(c1ccncc1)O,"InChI=1S/C21H18N4OS/c22-13-17(21(24)27-19-7-2-1-6-18(19)23)15-4-3-5-16(12-15)20(26)14-8-10-25-11-9-14/h1-12,20,26H,23-24H2/b21-17+",NHBMKTBZZSJUGA-HEHNFIMWSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.0,,IC50,,1000.0,,>,,,,15006386, mitogen-activated protein kinase kinase 4,2065,P45985,Human,compound 11 [PMID: 26431428],9989,,91936970,N#Cc1ccnc(c1)Nc1cc(n(n1)C1CCCC1)C1CCN(CC1)C1COC1,"InChI=1S/C22H28N6O/c23-13-16-5-8-24-21(11-16)25-22-12-20(28(26-22)18-3-1-2-4-18)17-6-9-27(10-7-17)19-14-29-15-19/h5,8,11-12,17-19H,1-4,6-7,9-10,14-15H2,(H,24,25,26)",GMTAOJMPNXLKJI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.3,,IC50,,5000.0,,>,,,,9353380, mitogen-activated protein kinase kinase 4,2065,P45985,Human,darizmetinib,12376,,139369660,CCCS(=O)(=O)Nc1c(ccc(c1F)C(=O)c1c2cc(cnc2n[nH]1)c1ccncc1)F,"InChI=1S/C21H17F2N5O3S/c1-2-9-32(30,31)28-19-16(22)4-3-14(17(19)23)20(29)18-15-10-13(11-25-21(15)27-26-18)12-5-7-24-8-6-12/h3-8,10-11,28H,2,9H2,1H3,(H,25,26,27)",WBNMARNYIFMNEP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.3,,IC50,,500.0,,<,Binned value from patent data,,,,