target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id mitogen-activated protein kinase kinase kinase 14,2074,Q99558,Human,compound 31 [PMID: 23374866],8174,,58221375,COCCOc1cnc(nc1c1c[nH]c2c1cc(C#CC(O)(C)C)cc2)N,"InChI=1S/C20H22N4O3/c1-20(2,25)7-6-13-4-5-16-14(10-13)15(11-22-16)18-17(27-9-8-26-3)12-23-19(21)24-18/h4-5,10-12,22,25H,8-9H2,1-3H3,(H2,21,23,24)",ZZIZLABGKZWVAW-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.7,,IC50,,20.0,,=,,,,23374866, mitogen-activated protein kinase kinase kinase 14,2074,Q99558,Human,NIK SMI1,9964,,117902000,COc1cc(nc(c1)c1cccc(c1)C#C[C@]1(O)CCN(C1=O)C)C(=O)N,"InChI=1S/C20H19N3O4/c1-23-9-8-20(26,19(23)25)7-6-13-4-3-5-14(10-13)16-11-15(27-2)12-17(22-16)18(21)24/h3-5,10-12,26H,8-9H2,1-2H3,(H2,21,24)/t20-/m0/s1",LQSHXYHWYGKAMX-FQEVSTJZSA-N,Inhibitor,Inhibition,,,yes,,pKi,,9.64,,Ki,,0.23,,=,,,,29330524, mitogen-activated protein kinase kinase kinase 14,2074,Q9WUL6,Mouse,NIK SMI1,9964,,117902000,COc1cc(nc(c1)c1cccc(c1)C#C[C@]1(O)CCN(C1=O)C)C(=O)N,"InChI=1S/C20H19N3O4/c1-23-9-8-20(26,19(23)25)7-6-13-4-3-5-14(10-13)16-11-15(27-2)12-17(22-16)18(21)24/h3-5,10-12,26H,8-9H2,1-2H3,(H2,21,24)/t20-/m0/s1",LQSHXYHWYGKAMX-FQEVSTJZSA-N,Inhibitor,Inhibition,,,,,pKi,,9.4,,Ki,,0.395,,=,,,,29330524, mitogen-activated protein kinase kinase kinase 14,2074,Q99558,Human,"compound 3a [Pipionne et al, 2018]",9965,,134611886,Cc1nn(c(c1c1ccc(c(c1)Cl)Cl)N)C(=O)C,"InChI=1S/C12H11Cl2N3O/c1-6-11(12(15)17(16-6)7(2)18)8-3-4-9(13)10(14)5-8/h3-5H,15H2,1-2H3",HJXDCOSNNVYHCY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.08,,IC50,,8400.0,,=,,,,30108985, mitogen-activated protein kinase kinase kinase 14,2074,Q99558,Human,NIK inhibitor 12f,10947,,146170996,CC(c1nccs1)(C#Cc1ccc(c(c1)Nc1ncnc2c1cc[nH]2)N1CCOCC1)O,"InChI=1S/C23H22N6O2S/c1-23(30,22-25-8-13-32-22)6-4-16-2-3-19(29-9-11-31-12-10-29)18(14-16)28-21-17-5-7-24-20(17)26-15-27-21/h2-3,5,7-8,13-15,30H,9-12H2,1H3,(H2,24,26,27,28)",KJMURTHIPWRIMC-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.01,,IC50,,9.87,,=,Inhibition of enzyme activity in a biochemical assay.,,,32479083, mitogen-activated protein kinase kinase kinase 14,2074,Q99558,Human,compound 18 [PMID: 34212719],11595,,156587558,C#Cc1ccnc(n1)C#Cc1ccc2c(c1)n(cn2)c1ccnc(n1)N,"InChI=1S/C19H11N7/c1-2-14-7-9-21-17(24-14)6-4-13-3-5-15-16(11-13)26(12-23-15)18-8-10-22-19(20)25-18/h1,3,5,7-12H,(H2,20,22,25)",WHGGGFMSJFAYSV-UHFFFAOYSA-N,Inhibitor,Irreversible inhibition,,,,,pIC50,,6.7,,IC50,,200.0,,=,,,,34212719, mitogen-activated protein kinase kinase kinase 14,2074,Q99558,Human,AMG28,12186,,58221549,CC(C)(C#Cc1cc2c(cc1)[nH]c1c2c2c(CCC1)cnc(n2)N)O,"InChI=1S/C20H20N4O/c1-20(2,25)9-8-12-6-7-15-14(10-12)17-16(23-15)5-3-4-13-11-22-19(21)24-18(13)17/h6-7,10-11,23,25H,3-5H2,1-2H3,(H2,21,22,24)",DGLFSNZWRYADFC-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,6.0,,Ki,,1000.0,,<,Enzymatic inhibition determined in a homogenous time resolved fluorescence (HTRF) assay for NIK (MAP3K14),,,,