target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,AZD1208,7698,,58423153,N[C@@H]1CCCN(C1)c1c(cccc1c1ccccc1)/C=C/1\SC(=O)NC1=O,"InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1",MCUJKPPARUPFJM-UWCCDQBKSA-N,Inhibitor,Inhibition,,,yes,,pKi,,9.64,,Ki,,0.23,,=,,,,24900629, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,compound 1a [PMID: 24900749],8128,,72163809,N#Cc1cnn2c1nc(Nc1ccc(c(c1)NC(=O)C)C)cc2NC1CC1,"InChI=1S/C19H19N7O/c1-11-3-4-15(7-16(11)22-12(2)27)23-17-8-18(24-14-5-6-14)26-19(25-17)13(9-20)10-21-26/h3-4,7-8,10,14,24H,5-6H2,1-2H3,(H,22,27)(H,23,25)",GDSQVLMYYCNAGP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.82,,IC50,,150.0,,=,,,,24900749, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,compound 20 [PMID: 22136433],8156,,54613583,N#CC1c2c3ccc(c(c3n(c2C(=O)NC21CCNCC2)C)Cl)Cl,"InChI=1S/C17H16Cl2N4O/c1-23-14-9(2-3-11(18)13(14)19)12-10(8-20)17(4-6-21-7-5-17)22-16(24)15(12)23/h2-3,10,21H,4-7H2,1H3,(H,22,24)",OWAWOKKHZNRHGV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.05,,IC50,,90.0,,=,,,,22136433, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,compound 14k [PMID: 21982499],8214,,44222958,Clc1ccccc1Nc1nc2c(cccc2c2c1ccnc2)c1[nH]cnn1,"InChI=1S/C20H13ClN6/c21-16-6-1-2-7-17(16)25-20-13-8-9-22-10-15(13)12-4-3-5-14(18(12)26-20)19-23-11-24-27-19/h1-11H,(H,25,26)(H,23,24,27)",WNOHFJIMKSDPHP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.07,,IC50,,86.0,,=,,,,21982499, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,SGI-1776,8784,,24795070,CN1CCC(CC1)CNc1ccc2n(n1)c(cn2)c1cccc(c1)OC(F)(F)F,"InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)",MHXGEROHKGDZGO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.16,,IC50,,69.0,,=,,,,22924342, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,LGB321,9367,,46179018,C[C@H]1CN(C[C@H]([C@@H]1O)N)c1ccncc1NC(=O)c1ccc(c(n1)c1c(F)cccc1F)F,"InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1",ODZZYKUYGVLOTQ-ONJZCGHCSA-N,Inhibitor,Inhibition,,,,,pKi,,12.1,,Ki,,8.0E-4,,=,Assayed at 40μM ATP,,,24474669, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,CX-6258,9368,,44545852,CN1CCCN(CC1)C(=O)c1cccc(c1)c1ccc(o1)/C=C\1/C(=O)Nc2c1cc(Cl)cc2,"InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+",KGBPLKOPSFDBOX-CJLVFECKSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.8,,IC50,,16.0,,=,,,,24900437, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,PIM447,9790,,44814409,C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(c(n1)c1c(F)cccc1F)F,"InChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1",VRQXRVAKPDCRCI-ZNMIVQPWSA-N,Inhibitor,Inhibition,,,,,pKi,,11.05,,Ki,,0.009,,=,,,,26505898, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,uzansertib,10626,,129606875,C[C@@H]1CN(C[C@@H]([C@H]1O)N)c1c(cnc2c1CC[C@@H]2O)NC(=O)c1ccc(c(n1)c1c(F)cccc1F)F,"InChI=1S/C26H26F3N5O3/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2,1H3,(H,33,37)/t12-,17+,20+,25+/m1/s1",PTORCEYGCGXHDH-SGQXWQAPSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.92,,IC50,,0.12,,=,Kinase inhibition in a biochemical enzyme activity assay.,,,29927999, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,GDC-0339,12708,,73603034,NC1=C(C(NC2=C(N3CC[C@@H](F)[C@H](N)CC3)N(N=C2)C)=O)N=C(C4=C(F)C=CC=C4F)S1,"InChI=1S/C20H22F3N7OS/c1-29-20(30-7-5-10(21)13(24)6-8-30)14(9-26-29)27-18(31)16-17(25)32-19(28-16)15-11(22)3-2-4-12(15)23/h2-4,9-10,13H,5-8,24-25H2,1H3,(H,27,31)/t10-,13-/m1/s1",NHXVGMQFCYBLTL-ZWNOBZJWSA-N,Inhibitor,Inhibition,,,,,pKi,,10.7,,Ki,,0.02,,=,,,,30715878, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,dapolsertib,13204,,76286825,CC(C)N1C2=CC(=C(C(=C2N=C1C3CCNCC3)[N+](=O)[O-])Br)Br,"InChI=1S/C15H18Br2N4O2/c1-8(2)20-11-7-10(16)12(17)14(21(22)23)13(11)19-15(20)9-3-5-18-6-4-9/h7-9,18H,3-6H2,1-2H3",UOUBCIJIWDLRGM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,,,,,,,,,=,,,,, "Pim-3 proto-oncogene, serine/threonine kinase",2160,Q86V86,Human,nuvisertib,13215,,66598080,[H][C@@]1(CC[C@@]([H])(CC1)C(C)(C)O)NC2=NN3C(C=C2)=NC=C3C4=CC=CC(=C4)C(F)(F)F,"InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-",XRNVABDYQLHODA-JCNLHEQBSA-N,Inhibitor,Inhibition,,,,,pKi,,7.38,,Ki,,42.0,,=,,,,24953177,