target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id myeloperoxidase,2789,P05164,Human,AZD5904,7728,,10264211,O=c1[nH]c(=S)n(c2c1[nH]cn2)C[C@H]1CCCO1,"InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1",RSPDBEVKURKEII-ZCFIWIBFSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.7,,IC50,,200.0,,=,Inhibition of the chlorination activity of MPO,,,21880720, myeloperoxidase,2789,P05164,Human,compound 28 [PMID: 28671460],9670,,2835211,COc1ccc2c(c1)nc(nc2C)N=C(N)N,"InChI=1S/C11H13N5O/c1-6-8-4-3-7(17-2)5-9(8)15-11(14-6)16-10(12)13/h3-5H,1-2H3,(H4,12,13,14,15,16)",ZJBMSSBTCGJZEE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.36,,IC50,,44.0,,=,,,,28671460, myeloperoxidase,2789,P05164,Human,aminopyridine 2,10051,,134813904,O=C(Nc1ccc(cc1)Br)NCc1ccc(nc1)N,"InChI=1S/C13H13BrN4O/c14-10-2-4-11(5-3-10)18-13(19)17-8-9-1-6-12(15)16-7-9/h1-7H,8H2,(H2,15,16)(H2,17,18,19)",NNDXEGUWCFIHTD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.8,,IC50,,160.0,,=,In a fluorescent MPO peroxidation biochemical assay.,,,30076263, myeloperoxidase,2789,P05164,Human,verdiperstat,10052,,11528958,CC(OCCn1c(=S)[nH]c(=O)c2c1cc[nH]2)C,"InChI=1S/C11H15N3O2S/c1-7(2)16-6-5-14-8-3-4-12-9(8)10(15)13-11(14)17/h3-4,7,12H,5-6H2,1-2H3,(H,13,15,17)",FVJCUZCRPIMVLB-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.2,,IC50,,630.0,,=,In a biochemical in vitro assay.,,,, myeloperoxidase,2789,P05164,Human,PF-06282999,10053,,71571306,COc1ccc(cc1c1cc(=O)[nH]c(=S)n1CC(=O)N)Cl,"InChI=1S/C13H12ClN3O3S/c1-20-10-3-2-7(14)4-8(10)9-5-12(19)16-13(21)17(9)6-11(15)18/h2-5H,6H2,1H3,(H2,15,18)(H,16,19,21)",ICYNYWFGIDGBRD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,6.5,,Ki,,316.0,,=,Inhibition of the peroxidase activity of MPO isolated from human polynuclear leukocytes.,,,26509551, myeloperoxidase,2789,P05164,Human,mitiperstat,12154,,121362450,C[C@H](c1c(ccc(c1)Cl)Cn1c2c(c(=O)[nH]c1=S)[nH]cc2)N,"InChI=1S/C15H15ClN4OS/c1-8(17)11-6-10(16)3-2-9(11)7-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,8,18H,7,17H2,1H3,(H,19,21,22)/t8-/m1/s1",BHKKSKOHRFHHIN-MRVPVSSYSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.15,,IC50,,0.7,,=,,,,30618054, myeloperoxidase,2789,P05164,Human,mitiperstat,12154,,121362450,C[C@H](c1c(ccc(c1)Cl)Cn1c2c(c(=O)[nH]c1=S)[nH]cc2)N,"InChI=1S/C15H15ClN4OS/c1-8(17)11-6-10(16)3-2-9(11)7-20-12-4-5-18-13(12)14(21)19-15(20)22/h2-6,8,18H,7,17H2,1H3,(H,19,21,22)/t8-/m1/s1",BHKKSKOHRFHHIN-MRVPVSSYSA-N,Inhibitor,Irreversible inhibition,,,,,pIC50,,8.82,,IC50,,1.5,,=,,,,36005476,