target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id NPFF1 receptor,300,Q9GZQ6,Human,1DMe,1477,,132709,CC(C[C@H](N(C(=O)[C@H](Cc1ccc(cc1)O)N)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CCCN=C(N)N)CCC(=O)N)CCC(=O)N)Cc1ccccc1)C,"InChI=1S/C55H78N14O11/c1-32(2)28-44(68(3)53(79)37(56)29-35-18-20-36(70)21-19-35)52(78)67-42(31-34-14-8-5-9-15-34)50(76)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)49(75)63-38(16-10-26-62-55(60)61)48(74)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,75)(H,64,77)(H,65,76)(H,66,74)(H,67,78)(H4,60,61,62)/t37-,38-,39-,40-,41-,42-,43-,44-/m0/s1",UQGBICZACVFETI-YTAGXALCSA-N,Agonist,Full agonist,,,,,pKi,9.0,,8.1,,,,,,,,,11024015|17011599|12421602, NPFF1 receptor,300,Q9GZQ6,Human,EFWSLAAPQRF-NH2,1478,,,,,,Agonist,Full agonist,,,,,pKi,,7.3,,,,,,=,,,,12242085|12421602, NPFF1 receptor,300,Q9GZQ6,Human,neuropeptide FF,1479,"Human, Mouse, Rat",123797,,,,Agonist,Full agonist,,yes,,,pKi,9.9,,8.5,,,,,=,,,,12242085|17011599|12421602, NPFF1 receptor,300,Q9GZQ6,Human,pancreatic polypeptide,1480,European common frog,,,,,Agonist,Partial agonist,,,,,pKi,,5.3,,,,,,,,,,11024015|12421602, NPFF1 receptor,300,Q9GZQ6,Human,Y-RFRP-3,1482,,155817415,CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O,"InChI=1S/C54H81N15O12/c1-29(2)25-39(66-49(77)38(28-43(57)72)65-51(79)41-15-10-24-69(41)53(81)44(30(3)4)67-46(74)34(55)26-32-16-18-33(70)19-17-32)52(80)68-23-9-14-40(68)50(78)63-36(20-21-42(56)71)48(76)62-35(13-8-22-61-54(59)60)47(75)64-37(45(58)73)27-31-11-6-5-7-12-31/h5-7,11-12,16-19,29-30,34-41,44,70H,8-10,13-15,20-28,55H2,1-4H3,(H2,56,71)(H2,57,72)(H2,58,73)(H,62,76)(H,63,78)(H,64,75)(H,65,79)(H,66,77)(H,67,74)(H4,59,60,61)/t34-,35-,36-,37-,38-,39-,40-,41-,44-/m0/s1",STIKMBSUWSFACN-OQGPALKGSA-N,Agonist,Full agonist,,,,,pKi,,9.4,,,,,,,,,,12242085|12421602, NPFF1 receptor,300,Q9GZQ6,Human,[125I]1DMe,1483,,,,,,Agonist,Full agonist,,,,,pKd,,8.9,,,,,,,,,,11024015, NPFF1 receptor,300,Q9GZQ6,Human,[125I]Y-RFRP-3,1484,,,,,,Agonist,Full agonist,,,,,pKd,,9.7,,Kd,,8.0,,=,,,,12421602, NPFF1 receptor,300,Q9GZQ6,Human,BIBP3226,1485,,5311023,O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O,"InChI=1S/C27H31N5O3/c28-27(29)30-17-7-12-23(25(34)31-18-19-13-15-22(33)16-14-19)32-26(35)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-6,8-11,13-16,23-24,33H,7,12,17-18H2,(H,31,34)(H,32,35)(H4,28,29,30)/t23-/m1/s1",KUWBXRGRMQZCSS-HSZRJFAPSA-N,Antagonist,Antagonist,,,,,pKi,7.8,,7.0,,,,,,,,,11024015|12242085|12421602, NPFF1 receptor,300,Q9GZQ6,Human,RF9,1486,,53320361,NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3,"InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1",UMKHUSRDQFQHAK-RNJMTYCLSA-N,Antagonist,Antagonist,,,,,pKi,,7.2,,,,,,=,,,,16407169, NPFF1 receptor,300,Q9GZQ6,Human,RFRP-3,4016,Human,,,,,Agonist,Full agonist,,yes,,,pKi,9.3,,9.2,,,,,=,,,,12242085|12421602|17337079, NPFF1 receptor,300,Q9GZQ6,Human,[3H]NPVF,4019,,,,,,Agonist,Full agonist,,,,,pKd,,8.6,,Kd,,2.65,,=,,,,19682524, NPFF1 receptor,300,Q9GZQ6,Human,compound 46 [PMID: 25268943],11235,,101882819,NC(=N)NCCNC(=O)C1(CCN(CC1)Cc1ccccc1)Nc1ccccc1,"InChI=1S/C22H30N6O/c23-21(24)26-14-13-25-20(29)22(27-19-9-5-2-6-10-19)11-15-28(16-12-22)17-18-7-3-1-4-8-18/h1-10,27H,11-17H2,(H,25,29)(H4,23,24,26)",SCPYAGLHLAAYFP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.09,,Ki,,81.0,,=,Binding affinity.,,,25268943,