target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id protein tyrosine phosphatase non-receptor type 22,3084,Q9Y2R2,Human,compound 8a [PMID: 23713581],8856,,71734765,CCCNC(=O)COc1ccc(cc1)c1oc2c(c1C#Cc1cccc(c1)Cl)cc(c(c2)O)C(=O)O,"InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34)",ZAKVHDWXAFAMTH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.77,,IC50,,171.0,,=,,,,23713581, protein tyrosine phosphatase non-receptor type 22,3084,Q9Y2R2,Human,NC1,10373,,6534740,CCOC(=O)c1ccc(cc1)N=C1S/C(=C\c2ccc(c(c2)OC)OCc2ccc(cc2)C(=O)O)/C(=O)N1C,"InChI=1S/C29H26N2O7S/c1-4-37-28(35)21-10-12-22(13-11-21)30-29-31(2)26(32)25(39-29)16-19-7-14-23(24(15-19)36-3)38-17-18-5-8-20(9-6-18)27(33)34/h5-16H,4,17H2,1-3H3,(H,33,34)/b25-16-,30-29?",MEYCXOYFLJPZOT-FXALAWDZSA-N,Inhibitor,Inhibition,,,yes,,pKi,,5.37,,Ki,,4300.0,,=,,,,30979725, protein tyrosine phosphatase non-receptor type 22,3084,Q9Y2R2,Human,I-C11,10374,,25262525,O=C(Nc1cccc2c1cccc2)CCCn1nnc(c1)c1c(oc2c1cc(C(=O)O)c(c2)O)c1ccccc1,"InChI=1S/C31H24N4O5/c36-26-17-27-23(16-22(26)31(38)39)29(30(40-27)20-9-2-1-3-10-20)25-18-35(34-33-25)15-7-14-28(37)32-24-13-6-11-19-8-4-5-12-21(19)24/h1-6,8-13,16-18,36H,7,14-15H2,(H,32,37)(H,38,39)",RSPKMGDZBNPGGF-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.34,,IC50,,4600.0,,=,"In vitro measurement of PTPN22-catalysed substrate dephosphorylation, using pNPP as a substrate at pH 7.0, 25°C, and ionic strength of 0.15 M.",,,18056643, protein tyrosine phosphatase non-receptor type 22,3084,Q9Y2R2,Human,I-C11,10374,,25262525,O=C(Nc1cccc2c1cccc2)CCCn1nnc(c1)c1c(oc2c1cc(C(=O)O)c(c2)O)c1ccccc1,"InChI=1S/C31H24N4O5/c36-26-17-27-23(16-22(26)31(38)39)29(30(40-27)20-9-2-1-3-10-20)25-18-35(34-33-25)15-7-14-28(37)32-24-13-6-11-19-8-4-5-12-21(19)24/h1-6,8-13,16-18,36H,7,14-15H2,(H,32,37)(H,38,39)",RSPKMGDZBNPGGF-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,5.54,,Ki,,2900.0,,=,,,,18056643,