target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id NOP receptor,320,P41146,Human,Ac-RYYRIK-NH2,1679,,9963005,CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O,"InChI=1S/C44H70N14O9/c1-4-25(2)36(42(67)54-31(37(46)62)9-5-6-20-45)58-39(64)33(11-8-22-52-44(49)50)55-40(65)34(23-27-12-16-29(60)17-13-27)57-41(66)35(24-28-14-18-30(61)19-15-28)56-38(63)32(53-26(3)59)10-7-21-51-43(47)48/h12-19,25,31-36,60-61H,4-11,20-24,45H2,1-3H3,(H2,46,62)(H,53,59)(H,54,67)(H,55,65)(H,56,63)(H,57,66)(H,58,64)(H4,47,48,51)(H4,49,50,52)/t25-,31-,32-,33-,34-,35-,36-/m0/s1",WBBBVZGQADABSU-RERZDIOCSA-N,Agonist,Agonist,,,,,pEC50,,5.1,,,,,,=,Stimulation of GTP-γ35S binding,,,9353393, NOP receptor,320,P41146,Human,Ac-RYYRIK-NH2,1679,,9963005,CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O,"InChI=1S/C44H70N14O9/c1-4-25(2)36(42(67)54-31(37(46)62)9-5-6-20-45)58-39(64)33(11-8-22-52-44(49)50)55-40(65)34(23-27-12-16-29(60)17-13-27)57-41(66)35(24-28-14-18-30(61)19-15-28)56-38(63)32(53-26(3)59)10-7-21-51-43(47)48/h12-19,25,31-36,60-61H,4-11,20-24,45H2,1-3H3,(H2,46,62)(H,53,59)(H,54,67)(H,55,65)(H,56,63)(H,57,66)(H,58,64)(H4,47,48,51)(H4,49,50,52)/t25-,31-,32-,33-,34-,35-,36-/m0/s1",WBBBVZGQADABSU-RERZDIOCSA-N,Agonist,Partial agonist,,,,,pKi,9.1,,8.82,Ki,1.5,,0.79,=,,,,9353393|12967935, NOP receptor,320,P35377,Mouse,Ac-RYYRIK-NH2,1679,,9963005,CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O,"InChI=1S/C44H70N14O9/c1-4-25(2)36(42(67)54-31(37(46)62)9-5-6-20-45)58-39(64)33(11-8-22-52-44(49)50)55-40(65)34(23-27-12-16-29(60)17-13-27)57-41(66)35(24-28-14-18-30(61)19-15-28)56-38(63)32(53-26(3)59)10-7-21-51-43(47)48/h12-19,25,31-36,60-61H,4-11,20-24,45H2,1-3H3,(H2,46,62)(H,53,59)(H,54,67)(H,55,65)(H,56,63)(H,57,66)(H,58,64)(H4,47,48,51)(H4,49,50,52)/t25-,31-,32-,33-,34-,35-,36-/m0/s1",WBBBVZGQADABSU-RERZDIOCSA-N,Agonist,Partial agonist,,,,,pKi,,8.8,,,,,,,,,,9353393, NOP receptor,320,P41146,Human,Ac-RYYRWK-NH2,1680,,,,,,Agonist,Agonist,,,,,pEC50,,8.68,,EC50,,2.1,,=,,,,9353393, NOP receptor,320,P41146,Human,Ac-RYYRWK-NH2,1680,,,,,,Agonist,Partial agonist,,,,,pKi,10.0,,9.15,Ki,0.71,,0.1,=,,,,9353393|12967935, NOP receptor,320,P35377,Mouse,Ac-RYYRWK-NH2,1680,,,,,,Agonist,Partial agonist,,,,,pKi,,9.2,,,,,,,,,,9353393, NOP receptor,320,P41146,Human,nociceptin/orphanin FQ,1681,"Human, Mouse, Rat",16131448,NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)N)CC(=O)N)C)CC(C)C)CCCCN)CCCNC(=N)N)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)N)C)CCCNC(=N)N,"InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1",PULGYDLMFSFVBL-SMFNREODSA-N,Agonist,Agonist,,,,,pEC50,9.8,,8.4,,,,,=,,,,9353393, NOP receptor,320,P41146,Human,nociceptin/orphanin FQ,1681,"Human, Mouse, Rat",16131448,NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)N)CC(=O)N)C)CC(C)C)CCCCN)CCCNC(=N)N)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)N)C)CCCNC(=N)N,"InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1",PULGYDLMFSFVBL-SMFNREODSA-N,Agonist,Full agonist,,,,,pKi,10.4,,9.7,,,,,=,,,,10369464|12070757|9413015, NOP receptor,320,P35377,Mouse,nociceptin/orphanin FQ,1681,"Human, Mouse, Rat",16131448,NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)N)CC(=O)N)C)CC(C)C)CCCCN)CCCNC(=N)N)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)N)C)CCCNC(=N)N,"InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1",PULGYDLMFSFVBL-SMFNREODSA-N,Agonist,Full agonist,,yes,,,pKi,,9.4,,,,,,,,,,9353393, NOP receptor,320,P41146,Human,N/OFQ-(1-13)-NH2,1682,,6324645,NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCCCN)CCCN=C(N)N)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)N)C)CCCN=C(N)N,"InChI=1S/C61H100N22O15/c1-34(75-47(87)32-74-59(98)49(36(3)85)83-57(96)44(29-38-18-8-5-9-19-38)77-48(88)31-72-46(86)30-73-53(92)39(64)28-37-16-6-4-7-17-37)51(90)79-43(23-15-27-71-61(68)69)55(94)81-41(21-11-13-25-63)56(95)82-45(33-84)58(97)76-35(2)52(91)80-42(22-14-26-70-60(66)67)54(93)78-40(50(65)89)20-10-12-24-62/h4-9,16-19,34-36,39-45,49,84-85H,10-15,20-33,62-64H2,1-3H3,(H2,65,89)(H,72,86)(H,73,92)(H,74,98)(H,75,87)(H,76,97)(H,77,88)(H,78,93)(H,79,90)(H,80,91)(H,81,94)(H,82,95)(H,83,96)(H4,66,67,70)(H4,68,69,71)/t34-,35-,36+,39-,40-,41-,42-,43-,44-,45-,49-/m0/s1",RHMALYOXPBRJBG-CGUXNFSNSA-N,Agonist,Full agonist,,,,,pKi,10.4,,10.1,,,,,=,,,,12967935|10369464|12070757|9191955, NOP receptor,320,P41146,Human,N/OFQ-NH2,1683,,,,,,Agonist,Full agonist,,,,,pKi,,10.4,,,,,,,,,,12967935, NOP receptor,320,P41146,Human,Ro64-6198,1684,,9844019,O=C1NCN(C21CCN(CC2)[C@H]1CC[C@H]2c3c1cccc3CCC2)c1ccccc1,"InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1",JLFMYEAXZNPWBK-REWPJTCUSA-N,Agonist,Agonist,,,,,pEC50,,7.41,,,,,,=,Stimulation of GTPγ35S binding,,,11006485, NOP receptor,320,P41146,Human,Ro64-6198,1684,,9844019,O=C1NCN(C21CCN(CC2)[C@H]1CC[C@H]2c3c1cccc3CCC2)c1ccccc1,"InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1",JLFMYEAXZNPWBK-REWPJTCUSA-N,Agonist,Full agonist,,,,,pKi,,9.41,,,,,,=,,,,10758169|11006485, NOP receptor,320,P41146,Human,UFP-102,1685,,,,,,Agonist,Full agonist,,,,,pKd,,10.7,,,,,,,,,,15509719, NOP receptor,320,P41146,Human,[(pF)Phe4]N/OFQ-(1-13)-NH2,1686,,,,,,Agonist,Agonist,,,,,pEC50,,10.12,,,,,,=,Stimulation of GTP-γ35S binding,,,15743186, NOP receptor,320,P41146,Human,[(pF)Phe4]N/OFQ-(1-13)-NH2,1686,,,,,,Agonist,Full agonist,,,,,pKi,11.32,,10.8,,,,,=,,,,12070757|15743186, NOP receptor,320,P35377,Mouse,[3H]Tyr14-N/OFQ,1687,,,,,,Agonist,Full agonist,,,,,pKd,,10.0,,,,,,,,,,9413015, NOP receptor,320,P41146,Human,[3H]N/OFQ,1688,,44361543,CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O,"InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1",PULGYDLMFSFVBL-SMFNREODSA-N,Agonist,Full agonist,,,,,pKd,10.2,,9.82,Kd,0.15,,0.063,=,,,,9353393|8849681, NOP receptor,320,P41146,Human,[Arg14Lys15]N/OFQ,1689,,,,,,Agonist,Full agonist,,,,,pKi,,9.5,,,,,,,,,,11097863, NOP receptor,320,P41146,Human,[F/G]N/OFQ-(1-13)-NH2,1690,,,,,,Agonist,Partial agonist,,,,,pKi,,9.2,,,,,,,,,,12967935, NOP receptor,320,P41146,Human,J-113397,1691,,5311194,OC[C@@H]1CN(CC[C@H]1n1c(=O)n(c2c1cccc2)CC)CC1CCCCCCC1,"InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1",MBGVUMXBUGIIBQ-LEWJYISDSA-N,Antagonist,Antagonist,,,,,pIC50,,8.3,,IC50,,,,=,,,,10602690, NOP receptor,320,P41146,Human,J-113397,1691,,5311194,OC[C@@H]1CN(CC[C@H]1n1c(=O)n(c2c1cccc2)CC)CC1CCCCCCC1,"InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1",MBGVUMXBUGIIBQ-LEWJYISDSA-N,Antagonist,Antagonist,,,,,pKi,,8.7,,,,,,=,,,,10940356, NOP receptor,320,P41146,Human,JTC-801,1692,,5311340,CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C,"InChI=1S/C26H25N3O2/c1-3-18-8-11-21(12-9-18)31-16-19-6-4-5-7-22(19)26(30)29-20-10-13-25-23(15-20)24(27)14-17(2)28-25/h4-15H,3,16H2,1-2H3,(H2,27,28)(H,29,30)",VTGBZWHPJFMTKS-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.1,,,,,,,,,,11101358, NOP receptor,320,P41146,Human,SB 612111,1693,,10047612,O[C@H]1C[C@H](CCc2c1cccc2C)CN1CCC(CC1)c1c(Cl)cccc1Cl,"InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3/t17-,23-/m0/s1",OHRDCQFCAWLDBP-SBUREZEXSA-N,Antagonist,Antagonist,,,,,pIC50,9.7,,8.2,,,,,=,,,,14593080|17329552, NOP receptor,320,P41146,Human,SB 612111,1693,,10047612,O[C@H]1C[C@H](CCc2c1cccc2C)CN1CCC(CC1)c1c(Cl)cccc1Cl,"InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3/t17-,23-/m0/s1",OHRDCQFCAWLDBP-SBUREZEXSA-N,Antagonist,Antagonist,,,,,pKi,9.5,,9.2,,,,,=,,,,14593080|17329552, NOP receptor,320,P41146,Human,UFP-101,1694,,25081457,NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCCCN)CCCN=C(N)N)CCCCN)CCCN=C(N)N)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CNCc1ccccc1)C)CCCN=C(N)N,"InChI=1S/C73H124N28O17/c1-42(91-57(106)40-90-70(118)59(44(3)103)101-68(116)53(35-45-19-6-4-7-20-45)93-58(107)39-89-56(105)38-88-55(104)37-84-36-46-21-8-5-9-22-46)61(109)95-50(26-16-32-85-71(78)79)65(113)98-49(25-12-15-31-76)67(115)100-54(41-102)69(117)92-43(2)62(110)96-51(27-17-33-86-72(80)81)66(114)97-48(24-11-14-30-75)64(112)99-52(28-18-34-87-73(82)83)63(111)94-47(60(77)108)23-10-13-29-74/h4-9,19-22,42-44,47-54,59,84,102-103H,10-18,23-41,74-76H2,1-3H3,(H2,77,108)(H,88,104)(H,89,105)(H,90,118)(H,91,106)(H,92,117)(H,93,107)(H,94,111)(H,95,109)(H,96,110)(H,97,114)(H,98,113)(H,99,112)(H,100,115)(H,101,116)(H4,78,79,85)(H4,80,81,86)(H4,82,83,87)/t42-,43-,44+,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1",JEXLNFNIIVBCHM-OSMJMQRHSA-N,Antagonist,Antagonist,,,,,pKi,,10.2,,,,,,=,,,,12010780, NOP receptor,320,P41146,Human,[Nphe1]N/OFQ-(1-13)-NH2,1695,,,,,,Antagonist,Antagonist,,,,,pKi,,8.4,,,,,,,,,,12010780, NOP receptor,320,P41146,Human,peptide III-BTD,1696,,5311338,CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H]1CCC2N(C1=O)[C@H](CS2)C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N)Cc1ccc(cc1)Cl)CCCN=C(N)N)CC1CCCCC1)CCCN=C(N)N,"InChI=1S/C40H62ClN13O7S/c1-22(55)49-26(9-5-17-47-39(43)44)34(57)53-30(20-23-7-3-2-4-8-23)36(59)51-28-15-16-32-54(38(28)61)31(21-62-32)37(60)50-27(10-6-18-48-40(45)46)35(58)52-29(33(42)56)19-24-11-13-25(41)14-12-24/h11-14,23,26-32H,2-10,15-21H2,1H3,(H2,42,56)(H,49,55)(H,50,60)(H,51,59)(H,52,58)(H,53,57)(H4,43,44,47)(H4,45,46,48)/t26-,27+,28+,29+,30-,31+,32?/m0/s1",TVMPRXGFXMXJRH-DLYPAOLNSA-N,Antagonist,Antagonist,,,,,pKi,,7.6,,,,,,,,,,10488086, NOP receptor,320,P41146,Human,[3H]Leu-N/OFQ,3824,,,,,,Agonist,Full agonist,,,,,pKd,,10.2,,Kd,,0.06,,=,,,,12967935, NOP receptor,320,P41146,Human,UFP-112,3917,,44430609,NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCC(=O)N)CC(=O)N)CCCCN)CCCNC(=N)N)CCCCN)CCCNC(=N)N)C)CO)NC(=O)[C@@H](NC(=O)C(NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccc(cc1)F)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)N)(C)C)CCCNC(=N)N,"InChI=1S/C83H139FN32O21/c1-44(67(125)107-54(22-14-34-98-80(92)93)70(128)108-51(19-8-11-31-85)69(127)111-55(23-15-35-99-81(94)95)71(129)109-52(20-9-12-32-86)72(130)112-58(39-61(90)120)75(133)106-50(66(91)124)29-30-60(89)119)104-77(135)59(43-117)113-73(131)53(21-10-13-33-87)110-74(132)56(24-16-36-100-82(96)97)114-79(137)83(3,4)116-64(123)42-103-78(136)65(45(2)118)115-76(134)57(38-47-25-27-48(84)28-26-47)105-63(122)41-101-62(121)40-102-68(126)49(88)37-46-17-6-5-7-18-46/h5-7,17-18,25-28,44-45,49-59,65,117-118H,8-16,19-24,29-43,85-88H2,1-4H3,(H2,89,119)(H2,90,120)(H2,91,124)(H,101,121)(H,102,126)(H,103,136)(H,104,135)(H,105,122)(H,106,133)(H,107,125)(H,108,128)(H,109,129)(H,110,132)(H,111,127)(H,112,130)(H,113,131)(H,114,137)(H,115,134)(H,116,123)(H4,92,93,98)(H4,94,95,99)(H4,96,97,100)/t44-,45+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,65-/m0/s1",GVIRJSRJRJCCJE-HCYVKCTOSA-N,Agonist,Full agonist,,,,,pEC50,9.71,,8.39,,,,,=,,,,17532097|19183962, NOP receptor,320,P41146,Human,compound 24 [PMID: 16451050],7361,,10296561,O=C([C@H]1CCCN1Cc1ccccc1)NCCCN1CCC2(CC1)OCc1c2cccc1,"InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1",MAKMQGKJURAJEN-RUZDIDTESA-N,Antagonist,Antagonist,,,,,pIC50,10.0,,9.57,IC50,0.27,,0.1,=,,,,19445927|16451050, NOP receptor,320,P41146,Human,compound 24 [PMID: 16451050],7361,,10296561,O=C([C@H]1CCCN1Cc1ccccc1)NCCCN1CCC2(CC1)OCc1c2cccc1,"InChI=1S/C27H35N3O2/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27/h1-5,8-11,25H,6-7,12-21H2,(H,28,31)/t25-/m1/s1",MAKMQGKJURAJEN-RUZDIDTESA-N,Antagonist,Antagonist,,,,,pKi,,9.62,,Ki,,0.24,,=,,,,19445927, NOP receptor,320,P41146,Human,(R)-Ro65-6570,8864,,15512229,O=C1NCN(C21CCN(CC2)[C@@H]1Cc2c3c1cccc3ccc2)c1ccccc1,"InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)/t22-/m1/s1",BBOAHBVXCYBKLC-JOCHJYFZSA-N,Agonist,Agonist,,,,,pEC50,,7.4,,,,,,=,Stimulation of GTP-γ35S binding,,,10476866, NOP receptor,320,P41146,Human,(R)-Ro65-6570,8864,,15512229,O=C1NCN(C21CCN(CC2)[C@@H]1Cc2c3c1cccc3ccc2)c1ccccc1,"InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)/t22-/m1/s1",BBOAHBVXCYBKLC-JOCHJYFZSA-N,Agonist,Agonist,,,,,pKi,,9.6,,,,,,=,,,,10476866, NOP receptor,320,P41146,Human,PWT2-N/OFQ,8865,,,,,,Agonist,Agonist,,,,,pEC50,,8.8,,,,,,=,Stimulation of GTP-γ35S binding,,,24903280, NOP receptor,320,P41146,Human,PWT2-N/OFQ,8865,,,,,,Agonist,Agonist,,,,,pKi,,10.3,,,,,,=,,,,24903280, NOP receptor,320,P41146,Human,cebranopadol,8866,,11848225,Fc1ccc2c(c1)c1CCOC3(c1[nH]2)CCC(CC3)(N(C)C)c1ccccc1,"InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3",CSMVOZKEWSOFER-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,7.89,,EC50,,13.0,,=,Stimulation of GTP-γ35S binding,,,24713140, NOP receptor,320,P41146,Human,cebranopadol,8866,,11848225,Fc1ccc2c(c1)c1CCOC3(c1[nH]2)CCC(CC3)(N(C)C)c1ccccc1,"InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3",CSMVOZKEWSOFER-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,9.05,,Ki,,0.9,,=,Radioligand binding assay,,,24713140, NOP receptor,320,P35370,Rat,cebranopadol,8866,,11848225,Fc1ccc2c(c1)c1CCOC3(c1[nH]2)CCC(CC3)(N(C)C)c1ccccc1,"InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3",CSMVOZKEWSOFER-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,9.0,,Ki,,1.0,,=,Radioligand binding assay,,,24713140, NOP receptor,320,P41146,Human,SR16835,8867,,49843739,O=C1Cc2c(N1C1CCN(CC1)C1CCC3c4c1cccc4CCC3)cccc2,"InChI=1S/C26H30N2O/c29-25-17-20-5-1-2-10-23(20)28(25)21-13-15-27(16-14-21)24-12-11-19-7-3-6-18-8-4-9-22(24)26(18)19/h1-2,4-5,8-10,19,21,24H,3,6-7,11-17H2",SZKWDIATUVLAAW-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,7.34,,EC50,,46.1,,=,Stimulation of GTP-γ35S binding,,,19773529, NOP receptor,320,P41146,Human,SR16835,8867,,49843739,O=C1Cc2c(N1C1CCN(CC1)C1CCC3c4c1cccc4CCC3)cccc2,"InChI=1S/C26H30N2O/c29-25-17-20-5-1-2-10-23(20)28(25)21-13-15-27(16-14-21)24-12-11-19-7-3-6-18-8-4-9-22(24)26(18)19/h1-2,4-5,8-10,19,21,24H,3,6-7,11-17H2",SZKWDIATUVLAAW-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,7.94,,Ki,,11.4,,=,Radioligand binding assay,,,19773529, NOP receptor,320,P41146,Human,SCH221510,8868,,9887077,Cc1ccccc1C(c1ccccc1C)N1C2CCC1CC(C2)(O)c1ccccc1,"InChI=1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3",LOSJNRBXNQTUNT-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,7.92,,EC50,,12.0,,=,Stimulation of GTP-γ35S binding,,,18492950, NOP receptor,320,P41146,Human,SCH221510,8868,,9887077,Cc1ccccc1C(c1ccccc1C)N1C2CCC1CC(C2)(O)c1ccccc1,"InChI=1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3",LOSJNRBXNQTUNT-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,9.52,,Ki,,0.3,,=,Radioligand binding assay,,,18492950, NOP receptor,320,P35377,Mouse,SCH221510,8868,,9887077,Cc1ccccc1C(c1ccccc1C)N1C2CCC1CC(C2)(O)c1ccccc1,"InChI=1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3",LOSJNRBXNQTUNT-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,8.94,,Ki,,1.15,,=,Radioligand binding assay,,,18492950, NOP receptor,320,P35370,Rat,SCH221510,8868,,9887077,Cc1ccccc1C(c1ccccc1C)N1C2CCC1CC(C2)(O)c1ccccc1,"InChI=1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3",LOSJNRBXNQTUNT-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,9.38,,Ki,,0.42,,=,Radioligand binding assay,,,18492950, NOP receptor,320,P41146,Human,SCH486757,8869,,11597355,Clc1ccccc1C(c1ccccc1Cl)N1[C@@H]2CC[C@H]1CC(C2)(O)c1ncccn1,"InChI=1S/C24H23Cl2N3O/c25-20-8-3-1-6-18(20)22(19-7-2-4-9-21(19)26)29-16-10-11-17(29)15-24(30,14-16)23-27-12-5-13-28-23/h1-9,12-13,16-17,22,30H,10-11,14-15H2/t16-,17+,24?",MQWMHMZNBGQNMT-LDSCYUJKSA-N,Agonist,Agonist,,,,,pEC50,,7.1,,EC50,,79.0,,=,Stimulation of GTP-γ35S binding,,,20006596, NOP receptor,320,P41146,Human,SCH486757,8869,,11597355,Clc1ccccc1C(c1ccccc1Cl)N1[C@@H]2CC[C@H]1CC(C2)(O)c1ncccn1,"InChI=1S/C24H23Cl2N3O/c25-20-8-3-1-6-18(20)22(19-7-2-4-9-21(19)26)29-16-10-11-17(29)15-24(30,14-16)23-27-12-5-13-28-23/h1-9,12-13,16-17,22,30H,10-11,14-15H2/t16-,17+,24?",MQWMHMZNBGQNMT-LDSCYUJKSA-N,Agonist,Agonist,,,,,pKi,,8.34,,Ki,,4.6,,=,Radioligand binding assay,,,20006596, NOP receptor,320,P41146,Human,AT-076,8870,,91938095,Oc1ccc2c(c1)CN[C@H](C2)C(=O)N[C@@H](C(C)C)CN1CCC(CC1)c1cccc(c1)O,"InChI=1S/C26H35N3O3/c1-17(2)25(16-29-10-8-18(9-11-29)19-4-3-5-22(30)12-19)28-26(32)24-14-20-6-7-23(31)13-21(20)15-27-24/h3-7,12-13,17-18,24-25,27,30-31H,8-11,14-16H2,1-2H3,(H,28,32)/t24-,25-/m1/s1",LGYDWJJZDCXEOV-JWQCQUIFSA-N,Antagonist,Antagonist,,,,,pKi,,8.76,,Ki,,1.75,,=,Radioligand binding assay,,,25635572, NOP receptor,320,P41146,Human,BU08028,9294,,50922685,CO[C@]12CC[C@]3(C[C@@H]1[C@@](C(CC)(C)C)(O)C)[C@@]14[C@H]2Oc2c4c(C[C@H]3N(CC1)CC1CC1)ccc2O,"InChI=1S/C30H43NO4/c1-6-26(2,3)27(4,33)21-16-28-11-12-30(21,34-5)25-29(28)13-14-31(17-18-7-8-18)22(28)15-19-9-10-20(32)24(35-25)23(19)29/h9-10,18,21-22,25,32-33H,6-8,11-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1",HBENZIXOGRCSQN-VQWWACLZSA-N,Agonist,Partial agonist,,,,,pKi,,8.07,,Ki,,8.46,,=,,,,21177476, NOP receptor,320,P41146,Human,LY2940094,9462,,52914971,OCc1cccnc1n1nc(c(c1)CN1CCC2(CC1)OCC(c1c2sc(c1)Cl)(F)F)C,"InChI=1S/C22H23ClF2N4O2S/c1-14-16(11-29(27-14)20-15(12-30)3-2-6-26-20)10-28-7-4-21(5-8-28)19-17(9-18(23)32-19)22(24,25)13-31-21/h2-3,6,9,11,30H,4-5,7-8,10,12-13H2,1H3",NKQHBJNRBKHUQR-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,10.0,,Ki,,0.1,,=,,,,24678969|31937563, NOP receptor,320,P41146,Human,AT-403,9747,,132427684,CNC(=O)CC1C(=O)N(c2c1cccc2)C1CCN(CC1)[C@@H]1CC[C@@H](CC1)C(C)C,"InChI=1S/C25H37N3O2/c1-17(2)18-8-10-19(11-9-18)27-14-12-20(13-15-27)28-23-7-5-4-6-21(23)22(25(28)30)16-24(29)26-3/h4-7,17-20,22H,8-16H2,1-3H3,(H,26,29)/t18-,19+,22?",IGSSUIQLZJANKJ-QIDMFYOTSA-N,Agonist,Agonist,,,,,pKi,,8.96,,Ki,,1.1,,=,,,,29232769, NOP receptor,320,P35377,Mouse,TRAP-101,10499,,11494970,OCC1=C(CCN(C1)CC1CCCCCCC1)n1c(=O)n(c2c1cccc2)CC,"InChI=1S/C24H35N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19,28H,2-7,10-11,14-18H2,1H3",DCRGHMJXEBSRQG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pA2,,7.75,,,,,,=,Antagonism of the electrically induced twitch response in mouse vas deferens stimulated by N/OFQ as agonist.,,,16202610, NOP receptor,320,P41146,Human,NiK-21273,10500,,24889797,NC(=O)Cn1c(C(=O)N2CCOCC2)c(c2c1cccc2)CN1CCC(CC1)c1c(F)cccc1Cl,"InChI=1S/C27H30ClFN4O3/c28-21-5-3-6-22(29)25(21)18-8-10-31(11-9-18)16-20-19-4-1-2-7-23(19)33(17-24(30)34)26(20)27(35)32-12-14-36-15-13-32/h1-7,18H,8-17H2,(H2,30,34)",YEDOPHDWRSVQOP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKB,,7.38,,KB,,41.7,,=,Antagonism of N/OFQ-induced calcium mobilisation in CHO cells expressing hNOP.,,,22994368, NOP receptor,320,P41146,Human,MCOPPB,12419,,24800108,CC1(CCCCCCC1)N2CCC(CC2)N3C(=NC4=C3C=CC=C4)[C@H]5CNCCC5,"InChI=1S/C26H40N4/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3/t21-/m1/s1",CYYNMPPFEJPBJD-OAQYLSRUSA-N,Agonist,Full agonist,,,,,pEC50,,9.41,,EC50,,0.39,,=,Potency determined in a functional assay; [35S]GTPγS recruitment,,,19125610, NOP receptor,320,P41146,Human,MCOPPB,12419,,24800108,CC1(CCCCCCC1)N2CCC(CC2)N3C(=NC4=C3C=CC=C4)[C@H]5CNCCC5,"InChI=1S/C26H40N4/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3/t21-/m1/s1",CYYNMPPFEJPBJD-OAQYLSRUSA-N,Agonist,Full agonist,,,,,pKi,,10.07,,Ki,,0.086,,=,Binding affinity for hNOP,,,19125610,