target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id TLX,615,Q9Y466,Human,BMS493,2641,,9909190,OC(=O)c1ccc(cc1)/C=C/c1ccc2c(c1)C(=CCC2(C)C)C#Cc1ccccc1,"InChI=1S/C29H24O2/c1-29(2)19-18-24(14-10-21-6-4-3-5-7-21)26-20-23(13-17-27(26)29)9-8-22-11-15-25(16-12-22)28(30)31/h3-9,11-13,15-18,20H,19H2,1-2H3,(H,30,31)/b9-8+",YCADIXLLWMXYKW-CMDGGOBGSA-N,Agonist,Agonist,,,,,pIC50,,7.27,,IC50,,54.0,,=,Full-length TLX luciferase reporter system in HEK293 cells.,,,32763139, TLX,615,Q9Y466,Human,tretinoin,2644,,444795,C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C,"InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+",SHGAZHPCJJPHSC-YCNIQYBTSA-N,Agonist,Agonist,,,,,pEC50,,5.74,,EC50,,1830.0,,=,Gal4-DBD TLX LBD screening to determine changes in TLX activity in HEK293 cells.,,,32763139, TLX,615,Q9Y466,Human,compound 10 [PMID: 34989568],11832,,162679531,O=C(c1cc(OCCCC)nc2c1cccc2)Nc1cc(C(F)(F)F)cc(n2cc(C)nc2)c1,"InChI=1S/C25H23F3N4O2/c1-3-4-9-34-23-13-21(20-7-5-6-8-22(20)31-23)24(33)30-18-10-17(25(26,27)28)11-19(12-18)32-14-16(2)29-15-32/h5-8,10-15H,3-4,9H2,1-2H3,(H,30,33)",RTKBIHCZDFXHLC-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKd,,5.72,,Kd,,1900.0,,=,Binding affinity for the TLX ligand binding domain determined by isothermal titration calorimetry,,,34989568,