target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id Glucocorticoid receptor,625,P04150,Human,dexamethasone,2768,,5743,OCC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F,"InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1",UREBDLICKHMUKA-CXSFZGCWSA-N,Agonist,Agonist,,,yes,,pIC50,9.0,,8.1,,,,,=,,,,8282004|10611474|10747884, Glucocorticoid receptor,625,P04150,Human,mifepristone,2805,,55245,CC#C[C@]1(O)CC[C@@H]2[C@]1(C)C[C@H](c1ccc(cc1)N(C)C)C1=C3CCC(=O)C=C3CC[C@@H]21,"InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1",VKHAHZOOUSRJNA-GCNJZUOMSA-N,Antagonist,Antagonist,,,yes,,pKd,,9.4,,,,,,=,,,,8282004|3560943, Glucocorticoid receptor,625,P04150,Human,prednisolone,2866,,5755,OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)C=C[C@]12C,"InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1",OIGNJSKKLXVSLS-VWUMJDOOSA-N,Agonist,Full agonist,,,yes,,pIC50,,8.15,,IC50,,7.0,,=,Binding to human GR in vitro.,,,29424542, Glucocorticoid receptor,625,P04150,Human,prednisolone,2866,,5755,OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)C=C[C@]12C,"InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1",OIGNJSKKLXVSLS-VWUMJDOOSA-N,Agonist,Full agonist,,,yes,,pIC50,,7.8,,IC50,,15.8,,=,,,,10747884, Glucocorticoid receptor,625,P04150,Human,prednisolone,2866,,5755,OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)C=C[C@]12C,"InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1",OIGNJSKKLXVSLS-VWUMJDOOSA-N,Agonist,Full agonist,,,yes,,pKi,,8.62,,Ki,,2.4,,=,,,,11520196, Glucocorticoid receptor,625,P04150,Human,triamcinolone acetonide,2867,,6436,OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1CCC1=CC(=O)C=C[C@]21C)F)(C)C,"InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1",YNDXUCZADRHECN-JNQJZLCISA-N,Agonist,Agonist,,,,,pIC50,,8.2,,,,,,=,,,,7472274|7583234, Glucocorticoid receptor,625,P04150,Human,cortisol,2868,,5754,OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C,"InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1",JYGXADMDTFJGBT-VWUMJDOOSA-N,Agonist,Agonist,,yes,yes,,pIC50,8.0,,7.3,,,,,=,,,,8282004|10611474|10747884, Glucocorticoid receptor,625,P06537,Mouse,corticosterone,2869,,5753,OCC(=O)[C@H]1CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C,"InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1",OMFXVFTZEKFJBZ-HJTSIMOOSA-N,Agonist,Agonist,,yes,yes,,pIC50,,7.2,,,,,,=,,,,8282004|10611474|10747884, Glucocorticoid receptor,625,P04150,Human,triamcinolone,2870,,31307,OCC(=O)[C@@]1(O)[C@H](O)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F,"InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1",GFNANZIMVAIWHM-OBYCQNJPSA-N,Agonist,Agonist,,,yes,,pIC50,,7.7,,,,,,=,,,,10747884, Glucocorticoid receptor,625,P04150,Human,deoxycorticosterone,2871,,6166,OCC(=O)[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C,"InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1",ZESRJSPZRDMNHY-YFWFAHHUSA-N,Agonist,Agonist,,yes,,,pIC50,,7.2,,,,,,=,,,,8282004|10747884, Glucocorticoid receptor,625,P04150,Human,onapristone,2882,,5311505,OCCC[C@@]1(O)CC[C@@H]2[C@@]1(C)C[C@H](c1ccc(cc1)N(C)C)C1=C3CCC(=O)C=C3CC[C@@H]21,"InChI=1S/C29H39NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h5-6,8-9,17,24-26,31,33H,4,7,10-16,18H2,1-3H3/t24-,25+,26-,28+,29+/m0/s1",IEXUMDBQLIVNHZ-YOUGDJEHSA-N,Antagonist,Antagonist,,,,,pIC50,,7.57,,IC50,,27.0,,=,,,,12781198, Glucocorticoid receptor,625,P04150,Human,RU28362,3445,,123790,CC#C[C@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2C=C(C2=CC(=O)C=C[C@]12C)C,"InChI=1S/C23H28O3/c1-5-8-23(26)10-7-17-16-11-14(2)18-12-15(24)6-9-21(18,3)20(16)19(25)13-22(17,23)4/h6,9,11-12,16-17,19-20,25-26H,7,10,13H2,1-4H3/t16-,17-,19-,20+,21-,22-,23-/m0/s1",UFZKDKHLKHEFGA-ZFTCBNFESA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,, Glucocorticoid receptor,625,,Unknown,RU26988,3446,,123987,CC#C[C@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2C=CC2=CC(=O)C=C[C@]12C,"InChI=1S/C22H26O3/c1-4-9-22(25)11-8-17-16-6-5-14-12-15(23)7-10-20(14,2)19(16)18(24)13-21(17,22)3/h5-7,10,12,16-19,24-25H,8,11,13H2,1-3H3/t16-,17-,18-,19+,20-,21-,22-/m0/s1",IXJKSIRTUSUXQC-ZXYIWLIBSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,, Glucocorticoid receptor,625,P04150,Human,[3H]dexamethasone,3447,,5743,OCC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F,"InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1",UREBDLICKHMUKA-CXSFZGCWSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,, Glucocorticoid receptor,625,P04150,Human,ZK112993,3448,,5311504,CC#C[C@]1(O)CC[C@H]2[C@]1(C)C[C@H](c1ccc(cc1)C(=O)C)C1=C3CCC(=O)C=C3CC[C@@H]21,"InChI=1S/C29H32O3/c1-4-14-29(32)15-13-26-24-11-9-21-16-22(31)10-12-23(21)27(24)25(17-28(26,29)3)20-7-5-19(6-8-20)18(2)30/h5-8,16,24-26,32H,9-13,15,17H2,1-3H3/t24-,25+,26+,28-,29-/m0/s1",OPKMKRUFBKTTRF-VBWGZTFCSA-N,Antagonist,Antagonist,,,,,,,,,,,,,=,,,,, Glucocorticoid receptor,625,P04150,Human,fluticasone,6699,,5311101,FCSC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F,"InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1",MGNNYOODZCAHBA-GQKYHHCASA-N,Agonist,Agonist,,,yes,,,,,,,,,,=,,,,, Glucocorticoid receptor,625,P04150,Human,beclometasone,7059,,20469,OCC(=O)[C@@]1(O)[C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl,"InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1",NBMKJKDGKREAPL-DVTGEIKXSA-N,Agonist,Full agonist,,,yes,,pKi,,8.43,,Ki,,3.74,,=,,,,, Glucocorticoid receptor,625,P04150,Human,betamethasone,7061,,9782,OCC(=O)[C@@]1(O)[C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F,"InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1",UREBDLICKHMUKA-DVTGEIKXSA-N,Agonist,Full agonist,,,yes,,pIC50,,8.11,,IC50,,7.74,,=,,,,, Glucocorticoid receptor,625,P04150,Human,clobetasol propionate,7062,,32798,CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F)C(=O)CCl,"InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1",CBGUOGMQLZIXBE-XGQKBEPLSA-N,Agonist,Agonist,,,yes,,pKi,,9.18,,Ki,,0.662,,=,,,,, Glucocorticoid receptor,625,P04150,Human,desoximetasone,7067,,5311067,OCC(=O)[C@H]1[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F,"InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1",VWVSBHGCDBMOOT-IIEHVVJPSA-N,Agonist,Agonist,,,yes,,pKi,,8.93,,Ki,,1.17,,=,,,,, Glucocorticoid receptor,625,P04150,Human,diflorasone diacetate,7068,,71414,CC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F)C(=O)COC(=O)C,"InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1",BOBLHFUVNSFZPJ-JOYXJVLSSA-N,Agonist,Agonist,,,yes,,pKi,,8.54,,Ki,,2.91,,=,,,,, Glucocorticoid receptor,625,P04150,Human,flunisolide,7076,,82153,OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1C[C@@H](C1=CC(=O)C=C[C@]21C)F)(C)C,"InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1",XSFJVAJPIHIPKU-XWCQMRHXSA-N,Agonist,Agonist,,,yes,,pKi,,8.62,,Ki,,2.42,,=,,,,, Glucocorticoid receptor,625,P04150,Human,fluocinolone acetonide,7077,,6215,OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1C[C@@H](C1=CC(=O)C=C[C@]21C)F)F)(C)C,"InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1",FEBLZLNTKCEFIT-VSXGLTOVSA-N,Agonist,Agonist,,,yes,,pIC50,,8.5,,IC50,,3.13,,=,,,,, Glucocorticoid receptor,625,P04150,Human,fluocinonide,7078,,9642,CC(=O)OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1C[C@@H](C1=CC(=O)C=C[C@]21C)F)F)(C)C,"InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1",WJOHZNCJWYWUJD-IUGZLZTKSA-N,Agonist,Agonist,,,yes,,pIC50,,8.28,,IC50,,5.26,,=,,,,, Glucocorticoid receptor,625,P04150,Human,fluorometholone,7079,,9878,O=C1C=C[C@]2(C(=C1)[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2([C@H]1CC[C@]2(O)C(=O)C)C)C,"InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1",FAOZLTXFLGPHNG-KNAQIMQKSA-N,Agonist,Agonist,,,yes,,pKi,,8.8,,Ki,,1.58,,=,,,,, Glucocorticoid receptor,625,P04150,Human,fluticasone propionate,7080,,444036,FCSC(=O)[C@@]1(OC(=O)CC)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F,"InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1",WMWTYOKRWGGJOA-CENSZEJFSA-N,Agonist,Agonist,,,yes,,pEC50,,8.05,,EC50,,9.0,,=,,,,28937774, Glucocorticoid receptor,625,P04150,Human,fluticasone propionate,7080,,444036,FCSC(=O)[C@@]1(OC(=O)CC)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F,"InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1",WMWTYOKRWGGJOA-CENSZEJFSA-N,Agonist,Agonist,,,yes,,pIC50,,9.3,,IC50,,0.5,,=,Inhibition of [3H]dexamethasone binding to recombinant human glucocorticoid receptor ecpressed in Tni cells.,,,10633034, Glucocorticoid receptor,625,P04150,Human,methylprednisolone,7088,,6741,OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)C,"InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1",VHRSUDSXCMQTMA-PJHHCJLFSA-N,Agonist,Agonist,,,yes,,pKi,,8.3,,Ki,,5.03,,=,,,,, Glucocorticoid receptor,625,P04150,Human,prednisone,7096,,5865,OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)CC(=O)[C@H]1[C@H]2CCC2=CC(=O)C=C[C@]12C,"InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1",XOFYZVNMUHMLCC-ZPOLXVRWSA-N,Agonist,Full agonist,,,yes,,pKi,,6.28,,Ki,,521.0,,=,,,,, Glucocorticoid receptor,625,P04150,Human,budesonide,7434,,5281004,CCCC1O[C@H]2[C@](O1)(C(=O)CO)[C@@]1([C@@H](C2)[C@@H]2CCC3=CC(=O)C=C[C@@]3([C@H]2[C@H](C1)O)C)C,"InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1",VOVIALXJUBGFJZ-KWVAZRHASA-N,Agonist,Agonist,,,yes,,pEC50,,7.91,,EC50,,12.4,,=,,,,21880489, Glucocorticoid receptor,625,P04150,Human,budesonide,7434,,5281004,CCCC1O[C@H]2[C@](O1)(C(=O)CO)[C@@]1([C@@H](C2)[C@@H]2CCC3=CC(=O)C=C[C@@]3([C@H]2[C@H](C1)O)C)C,"InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1",VOVIALXJUBGFJZ-KWVAZRHASA-N,Agonist,Agonist,,,yes,,pEC50,,7.42,,EC50,,38.0,,=,,,,28937774, Glucocorticoid receptor,625,P04150,Human,ciclesonide,7469,,6918155,O=C(C(C)C)OCC(=O)[C@@]12O[C@@H](O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1CCC1=CC(=O)C=C[C@]21C)C1CCCCC1,"InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1",LUKZNWIVRBCLON-GXOBDPJESA-N,Agonist,Agonist,,,yes,,pKi,,7.43,,Ki,,37.0,,=,,,,15878996, Glucocorticoid receptor,625,P04150,Human,difluprednate,7474,,443936,CCCC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F)C(=O)COC(=O)C,"InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1",WYQPLTPSGFELIB-JTQPXKBDSA-N,Agonist,Agonist,,,yes,,,,,,,,,,=,,,,21182429, Glucocorticoid receptor,625,P04150,Human,ZK216348,8643,,9805004,O=C(C(C(F)(F)F)(CC(c1cccc2c1OCC2)(C)C)O)Nc1ccc2c(c1)c(C)noc2=O,"InChI=1S/C24H23F3N2O5/c1-13-17-11-15(7-8-16(17)20(30)34-29-13)28-21(31)23(32,24(25,26)27)12-22(2,3)18-6-4-5-14-9-10-33-19(14)18/h4-8,11,32H,9-10,12H2,1-3H3,(H,28,31)",VRZVKIJRJRBQJT-UHFFFAOYSA-N,Agonist,Agonist,,,,,pIC50,,7.69,,IC50,,20.3,,=,,,,14694204, Glucocorticoid receptor,625,P04150,Human,mometasone,9029,,441335,ClCC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl,"InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1",QLIIKPVHVRXHRI-CXSFZGCWSA-N,Agonist,Agonist,,,yes,,,,,,,,,,=,,,,, Glucocorticoid receptor,625,P04150,Human,C108297,9180,,25110774,COCCOC[C@@]12Cc3cnn(c3C=C2CCN(C1)S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)F,"InChI=1S/C30H36FN3O4S/c1-29(2,3)23-5-11-27(12-6-23)39(35,36)33-14-13-24-17-28-22(18-30(24,20-33)21-38-16-15-37-4)19-32-34(28)26-9-7-25(31)8-10-26/h5-12,17,19H,13-16,18,20-21H2,1-4H3/t30-/m1/s1",OMKDFVUMRKROMY-SSEXGKCCSA-N,Agonist,Agonist,,,,,pKi,,9.15,,Ki,,0.7,,=,,,,18226897, Glucocorticoid receptor,625,P04150,Human,vamorolone,9247,,3035000,OCC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@]1(C)CC=C1[C@H]2CCC2=CC(=O)C=C[C@]12C,"InChI=1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1",ZYTXTXAMMDTYDQ-DGEXFFLYSA-N,None,Binding,,,yes,,,,,,,,,,=,,,,24014378|23498916, Glucocorticoid receptor,625,P04150,Human,velsecorat,9325,,67041274,C[C@@H]([C@@H](c1ccc2c(c1)OCCO2)Oc1ccc2c(c1)cnn2c1cccc(c1)C(=O)N[C@H]1COCC1)NC(=O)C(F)(F)C,"InChI=1S/C32H32F2N4O6/c1-19(36-31(40)32(2,33)34)29(20-6-9-27-28(16-20)43-13-12-42-27)44-25-7-8-26-22(15-25)17-35-38(26)24-5-3-4-21(14-24)30(39)37-23-10-11-41-18-23/h3-9,14-17,19,23,29H,10-13,18H2,1-2H3,(H,36,40)(H,37,39)/t19-,23+,29-/m0/s1",ZZWJKLGCDHYVMB-BWGXUDETSA-N,Agonist,Agonist,,,,,pEC50,,9.05,,EC50,,0.9,,=,Measuring displacement of 3H-dexamethasone from the human GR in a competition radioligand binding assay.,,,28937774, Glucocorticoid receptor,625,P04150,Human,fosdagrocorat,9649,,24872952,O=C(c1ccc2c(c1)CC[C@H]1[C@]2(CC[C@](C1)(OP(=O)(O)O)C(F)(F)F)Cc1ccccc1)Nc1cccnc1C,"InChI=1S/C29H30F3N2O5P/c1-19-25(8-5-15-33-19)34-26(35)22-10-12-24-21(16-22)9-11-23-18-28(29(30,31)32,39-40(36,37)38)14-13-27(23,24)17-20-6-3-2-4-7-20/h2-8,10,12,15-16,23H,9,11,13-14,17-18H2,1H3,(H,34,35)(H2,36,37,38)/t23-,27+,28-/m1/s1",BVXLAHSJXXSWFF-KEKPKEOLSA-N,Agonist,Partial agonist,,,,,pIC50,,7.1,,IC50,,79.0,,=,Measured in a glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay.,,,, Glucocorticoid receptor,625,P04150,Human,dagrocorat,9650,,24873449,O=C(c1ccc2c(c1)CC[C@H]1[C@]2(CC[C@](C1)(O)C(F)(F)F)Cc1ccccc1)Nc1cccnc1C,"InChI=1S/C29H29F3N2O2/c1-19-25(8-5-15-33-19)34-26(35)22-10-12-24-21(16-22)9-11-23-18-28(36,29(30,31)32)14-13-27(23,24)17-20-6-3-2-4-7-20/h2-8,10,12,15-16,23,36H,9,11,13-14,17-18H2,1H3,(H,34,35)/t23-,27+,28-/m1/s1",QJJBNCHSWFGXML-KEKPKEOLSA-N,Agonist,Partial agonist,,,,,pIC50,,8.88,,IC50,,1.31,,=,Measured in a glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay.,,,, Glucocorticoid receptor,625,P04150,Human,GSK866,9653,,25058139,CCN(C(=O)c1c(Cl)cccc1Cl)C[C@](C(F)(F)F)(CNC(=O)c1cnn(c1N)c1ccc(cc1)F)O,"InChI=1S/C23H21Cl2F4N5O3/c1-2-33(21(36)18-16(24)4-3-5-17(18)25)12-22(37,23(27,28)29)11-31-20(35)15-10-32-34(19(15)30)14-8-6-13(26)7-9-14/h3-10,37H,2,11-12,30H2,1H3,(H,31,35)/t22-/m0/s1",LKQMULLPLYLIGW-QFIPXVFZSA-N,Agonist,Agonist,,,yes,,pIC50,,8.5,,IC50,,3.16,,=,,,,18952422, Glucocorticoid receptor,625,P04150,Human,mapracorat,9654,,24795088,Fc1cc2CCOc2c(c1)C(C[C@](C(F)(F)F)(CNc1cccc2c1ccc(n2)C)O)(C)C,"InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m1/s1",VJGFOYBQOIPQFY-XMMPIXPASA-N,Agonist,Agonist,,,yes,,,,,,,,,,=,,,,19422381, Glucocorticoid receptor,625,P04150,Human,BI 653048,9715,,44543970,CCS(=O)(=O)c1ncc2c(c1)cc([nH]2)C[C@@](C(F)(F)F)(CC(c1ccc(cc1C(=O)N)F)(C)C)O,"InChI=1S/C23H25F4N3O4S/c1-4-35(33,34)19-8-13-7-15(30-18(13)11-29-19)10-22(32,23(25,26)27)12-21(2,3)17-6-5-14(24)9-16(17)20(28)31/h5-9,11,30,32H,4,10,12H2,1-3H3,(H2,28,31)/t22-/m0/s1",AUIFRJWXYUNPPV-QFIPXVFZSA-N,Agonist,Agonist,,,,,pIC50,,7.15,,IC50,,70.0,,=,,,,25516791, Glucocorticoid receptor,625,P04150,Human,benzodrocortisone,9731,,119845,OCC(=O)[C@]1(CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C)OC(=O)c1ccccc1,"InChI=1S/C28H34O6/c1-26-12-10-19(30)14-18(26)8-9-20-21-11-13-28(23(32)16-29,27(21,2)15-22(31)24(20)26)34-25(33)17-6-4-3-5-7-17/h3-7,14,20-22,24,29,31H,8-13,15-16H2,1-2H3/t20-,21-,22-,24+,26-,27-,28-/m0/s1",LPEYMYDYPGRLBU-YGZHYJPASA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,, Glucocorticoid receptor,625,P04150,Human,AZD9567,9812,,121248172,CC([C@@H]([C@@H](c1ccccc1)Oc1ccc2c(c1)cnn2c1ccc(=O)n(c1)C)NC(=O)C(F)(F)C)C,"InChI=1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1",ZQFNDBISEYQVRR-LOSJGSFVSA-N,Agonist,Partial agonist,,,yes,,pEC50,,7.96,,EC50,,11.0,,=,In a cellular transactivation assay.,,,29424542, Glucocorticoid receptor,625,P04150,Human,AZD9567,9812,,121248172,CC([C@@H]([C@@H](c1ccccc1)Oc1ccc2c(c1)cnn2c1ccc(=O)n(c1)C)NC(=O)C(F)(F)C)C,"InChI=1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1",ZQFNDBISEYQVRR-LOSJGSFVSA-N,Agonist,Partial agonist,,,yes,,pIC50,,8.42,,IC50,,3.8,,=,Binding to human GR in vitro .,,,29424542, Glucocorticoid receptor,625,P04150,Human,compound 17 [PMID: 29741897],10005,,58392644,OCC(=O)[C@@]12CN(C[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1C[C@@H](C1=CC(=O)C=C[C@]21C)F)F)Cc1cccc(c1)Cl,"InChI=1S/C30H34ClF2NO4/c1-27-7-6-20(36)10-23(27)24(32)11-22-21-9-18-14-34(13-17-4-3-5-19(31)8-17)16-29(18,26(38)15-35)28(21,2)12-25(37)30(22,27)33/h3-8,10,18,21-22,24-25,35,37H,9,11-16H2,1-2H3/t18-,21-,22-,24-,25-,27-,28-,29+,30-/m0/s1",AOSZTAHDEDLTLQ-AZKQZHLXSA-N,Agonist,Agonist,,,,,pKi,,9.12,,Ki,,0.76,,=,Binding Ki.,,,29741897, Glucocorticoid receptor,625,P04150,Human,miricorilant,10059,,66550324,O=c1[nH]c(=O)c(c([nH]1)[C@@H]1CC[C@H](CC1)c1ccccc1)Cc1cccc(c1)C(F)(F)F,"InChI=1S/C24H23F3N2O2/c25-24(26,27)19-8-4-5-15(13-19)14-20-21(28-23(31)29-22(20)30)18-11-9-17(10-12-18)16-6-2-1-3-7-16/h1-8,13,17-18H,9-12,14H2,(H2,28,29,30,31)/t17-,18-",GVVUZBSCYAVFTI-IYARVYRRSA-N,Antagonist,Antagonist,,,yes,,pKi,,8.1,,Ki,,8.0,,=,Determined by measuring displacement of [3H]dexamethasone from recombinant baculovirus derived human GR.,,,23131342, Glucocorticoid receptor,625,P04150,Human,ORG 214007-0,11310,,154659439,N#Cc1ccc2c(c1)[C@@H](C)c1ccccc1[C@H]1N2CC[C@@H](C1)NC(=O)c1snnc1C,"InChI=1S/C24H23N5OS/c1-14-18-5-3-4-6-19(18)22-12-17(26-24(30)23-15(2)27-28-31-23)9-10-29(22)21-8-7-16(13-25)11-20(14)21/h3-8,11,14,17,22H,9-10,12H2,1-2H3,(H,26,30)/t14-,17-,22-/m0/s1",BUWMTEGCNUYHSZ-JKXTWKSPSA-N,Agonist,Partial agonist,,,,,pEC50,,8.29,,EC50,,5.1,,=,In a co-factor recruitment assay.,,,23152771, Glucocorticoid receptor,625,P04150,Human,ORG 214007-0,11310,,154659439,N#Cc1ccc2c(c1)[C@@H](C)c1ccccc1[C@H]1N2CC[C@@H](C1)NC(=O)c1snnc1C,"InChI=1S/C24H23N5OS/c1-14-18-5-3-4-6-19(18)22-12-17(26-24(30)23-15(2)27-28-31-23)9-10-29(22)21-8-7-16(13-25)11-20(14)21/h3-8,11,14,17,22H,9-10,12H2,1-2H3,(H,26,30)/t14-,17-,22-/m0/s1",BUWMTEGCNUYHSZ-JKXTWKSPSA-N,Agonist,Partial agonist,,,,,pKi,,8.66,,Ki,,2.2,,=,In a binding assay.,,,23152771, Glucocorticoid receptor,625,P06537,Mouse,CpdA (parent molecule),11317,,9838148,CNCC(c1ccc(cc1)OC(=O)C)Cl,"InChI=1S/C11H14ClNO2/c1-8(14)15-10-5-3-9(4-6-10)11(12)7-13-2/h3-6,11,13H,7H2,1-2H3",VZCQEZNQVVYTJC-UHFFFAOYSA-N,Agonist,Agonist,,,,,pIC50,,8.19,,IC50,,6.4,,=,"Whole-cell binding assay performed in L929sA cells, measuring displacement of with [3H]DEX binding to the endogenous mGR.",,,16243974, Glucocorticoid receptor,625,P04150,Human,AZD2906,11780,,25013811,C[C@@H]([C@@H](c1cnc(cc1)OC)Oc1cc2c(cc1)n(nc2)c1ccc(cc1)F)NC(=O)C1CC1,"InChI=1S/C26H25FN4O3/c1-16(30-26(32)17-3-4-17)25(18-5-12-24(33-2)28-14-18)34-22-10-11-23-19(13-22)15-29-31(23)21-8-6-20(27)7-9-21/h5-17,25H,3-4H2,1-2H3,(H,30,32)/t16-,25-/m0/s1",YDRQCGICZKAGCQ-LMKMVOKYSA-N,Agonist,Agonist,,,,,pEC50,,8.89,,EC50,,1.3,,=,Measuring hGR-mediated transactivation in ChaGoK1 cells,,,29424542, Glucocorticoid receptor,625,P04150,Human,LEO 134310,11901,,126714060,C[C@H](NC(=O)[C@H]1CCCO1)[C@H](Oc1ccc(cc1)C(=O)O[C@H]1CCCN(C1)C(=O)[C@H]1COC(=O)C1)c1ccc(cc1)C1CC1,"InChI=1S/C34H40N2O8/c1-21(35-32(38)29-5-3-17-41-29)31(24-10-8-23(9-11-24)22-6-7-22)43-27-14-12-25(13-15-27)34(40)44-28-4-2-16-36(19-28)33(39)26-18-30(37)42-20-26/h8-15,21-22,26,28-29,31H,2-7,16-20H2,1H3,(H,35,38)/t21-,26+,28-,29+,31-/m0/s1",NADMBBGHEQYUMJ-WDXNIXBWSA-N,Agonist,Agonist,,,,,pEC50,,7.85,,EC50,,14.0,,=,In a GR binding assay,,,35087193, Glucocorticoid receptor,625,P04150,Human,ABBV-3373,12917,,,,,,Agonist,Agonist,,,,,pIC50,,8.52,,IC50,,3.0,,=,"GR binding, for the payload component of this ADC",,,36394224, Glucocorticoid receptor,625,P04150,Human,AZD5423,13017,,24825740,C[C@@H]([C@@H](C1=CC(=CC=C1)OC)OC2=CC3=C(C=C2)N(N=C3)C4=CC=C(C=C4)F)NC(=O)C(F)(F)F,"InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1",FCNQMDSJHADDFT-WNSKOXEYSA-N,Antagonist,Antagonist,,,,,pIC50,,10.31,,IC50,,0.049,,=,Measuring transrepression of glucocorticoid receptor-mediated transcriptional activity in PMA-stimulated human ChaGoK1 cells,,,28937774, Glucocorticoid receptor,625,P04150,Human,ORIC-101,13167,,134415769,CC(C)N(C)C1=CC=C(C=C1)[C@H]2C[C@]3([C@@H](CC[C@]3(C#CC(C)(C)C)O)[C@H]4[C@H]2[C@H]5CCC(=O)C=C5CC4)C,"InChI=1S/C34H47NO2/c1-22(2)35(7)25-11-8-23(9-12-25)29-21-33(6)30(16-17-34(33,37)19-18-32(3,4)5)28-14-10-24-20-26(36)13-15-27(24)31(28)29/h8-9,11-12,20,22,27-31,37H,10,13-17,21H2,1-7H3/t27-,28-,29+,30-,31+,33-,34+/m0/s1",VNLTWJIWEYPBIF-KMSLUKAPSA-N,Antagonist,Antagonist,,,,,pIC50,,8.25,,IC50,,5.6,,=,Inhibitory potency determined in a GR luciferase antagonist assay.,,,30091920, Glucocorticoid receptor,625,P04150,Human,dazucorilant,13264,,72192163,C1CN(C[C@@]2(C1=CC3=C(C2)C=NN3C4=CC=C(C=C4)F)C(=O)C5=CC=CC=N5)S(=O)(=O)C6=CC=C(C=C6)C(F)(F)F,"InChI=1S/C29H22F4N4O3S/c30-22-6-8-23(9-7-22)37-26-15-21-12-14-36(41(39,40)24-10-4-20(5-11-24)29(31,32)33)18-28(21,16-19(26)17-35-37)27(38)25-3-1-2-13-34-25/h1-11,13,15,17H,12,14,16,18H2/t28-/m0/s1",VXOBXKQLNWYQPQ-NDEPHWFRSA-N,Antagonist,Antagonist,,,,,pKi,,9.55,,Ki,,0.28,,=,Determined in a glucocorticoid receptor competitor fluorescence polarization- displacing fluormone GS Red.,,,28368581,