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24264
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38134
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80011
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{
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347
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157
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{
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348
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154,
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407
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193
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406
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70
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{
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"affinity": "7.9",
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"dataPointInteractionIds": [
516
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193
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{
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79419
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"refIds": [
24264
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},
{
"targetId": 6,
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"ligandId": 9099,
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"affinity": "9.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
83502
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"refIds": [
30814,
30815
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},
{
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"affinity": "8.0 - 8.4",
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"dataPointInteractionIds": [
466,
80004
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"refIds": [
204,
24716
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"dataPointInteractionIds": [
79771
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"refIds": [
24531
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{
"targetId": 6,
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"primaryTarget": false,
"ligandId": 7556,
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"affinity": "4.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79983
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"refIds": [
3003
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},
{
"targetId": 6,
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"ligandId": 88,
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"dataPointInteractionIds": [
482
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"refIds": [
182,
196,
202
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{
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"selectivity": "Not Determined",
"affinity": "7.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
676
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"refIds": [
193
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},
{
"targetId": 8,
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"ligandId": 198,
"ligandName": "agomelatine",
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"action": "Antagonist",
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"affinity": "6.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
714
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"refIds": [
203
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},
{
"targetId": 8,
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"ligandId": 214,
"ligandName": "trifluoperazine",
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"affinity": "6.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
747
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"refIds": [
193
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},
{
"targetId": 8,
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"ligandId": 7227,
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"affinity": "6.4",
"affinityParameter": "pKi",
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82617
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"refIds": [
24264
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},
{
"targetId": 8,
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"ligandId": 200,
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"affinity": "8.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80005
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"refIds": [
24716
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},
{
"targetId": 9,
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"targetSpecies": "Human",
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"ligandId": 7427,
"ligandName": "vilazodone",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.6",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79696
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"refIds": [
24428
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},
{
"targetId": 10,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
79603
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24039
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},
{
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"dataPointInteractionIds": [
79604
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24039
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},
{
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"selectivity": "Not Determined",
"affinity": "6.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
878
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"refIds": [
367
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},
{
"targetId": 12,
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"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "7.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
980
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"refIds": [
367
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},
{
"targetId": 12,
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"targetSpecies": "Rat",
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"ligandId": 90,
"ligandName": "pimozide",
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
1049
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"refIds": [
370
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},
{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9658,
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84549
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"refIds": [
33523
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},
{
"targetId": 13,
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7438,
"ligandName": "methacholine",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "6.4",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79736
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"refIds": [
413,
24488
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},
{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 297,
"ligandName": "bethanechol",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "4.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1084
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"refIds": [
413,
482
]
},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 298,
"ligandName": "carbachol",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "3.2 - 5.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1085
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"refIds": [
482,
483,
484
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},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 57,
"ligandName": "xanomeline",
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"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "6.7 - 7.9",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1098
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"refIds": [
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483,
484,
44694
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},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 305,
"ligandName": "pilocarpine",
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"action": "Partial agonist",
"selectivity": "Not Determined",
"affinity": "5.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1095
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"refIds": [
413,
482
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},
{
"targetId": 13,
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"targetSpecies": "Mouse",
"primaryTarget": false,
"ligandId": 6687,
"ligandName": "tacrine",
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"selectivity": "Not Determined",
"affinity": "5.7",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
80070
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"refIds": [
25124
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},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7449,
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"action": "Antagonist",
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"affinity": "10.1 - 10.2",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79748
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"refIds": [
24507,
41876
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},
{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 360,
"ligandName": "tolterodine",
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"action": "Antagonist",
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"affinity": "8.4 - 8.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82383
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"refIds": [
28681,
28683
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},
{
"targetId": 13,
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"targetSpecies": "Human",
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"ligandId": 367,
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"action": "Antagonist",
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"affinity": "9.6 - 10.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82388
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"refIds": [
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41876
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{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7354,
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"action": "Antagonist",
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"affinity": "9.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79609
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"refIds": [
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28686
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{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7483,
"ligandName": "solifenacin",
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"affinity": "7.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82380
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"refIds": [
28680,
28681
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},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Rat",
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"ligandId": 359,
"ligandName": "oxybutynin",
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"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82382
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"refIds": [
28682
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},
{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Rat",
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"ligandId": 7483,
"ligandName": "solifenacin",
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"action": "Antagonist",
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"affinity": "8.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
82381
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"refIds": [
28682
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},
{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 7483,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.2",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
79792
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"refIds": [
24561
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},
{
"targetId": 13,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 321,
"ligandName": "darifenacin",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "8.9 - 9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1117
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"refIds": [
494,
28681,
28683
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{
"targetId": 13,
"targetName": "M1 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 325,
"ligandName": "ipratropium",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.3 - 9.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
1121
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"refIds": [
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24507
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"targetId": 13,
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"targetSpecies": "Human",
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"ligandId": 7391,
"ligandName": "droxidopa",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
87957
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"refIds": [
41877
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},
{
"targetId": 13,
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"targetSpecies": "Human",
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"ligandId": 7549,
"ligandName": "dosulepin",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "7.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
79970
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"refIds": [
24715
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},
{
"targetId": 13,
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"ligandId": 10129,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85692
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"refIds": [
36350
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},
{
"targetId": 13,
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"ligandId": 7601,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80058
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"refIds": [
24953
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},
{
"targetId": 13,
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1643
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45304
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879,
45304
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45304
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1641
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882,
45304
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45304
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45304
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90314
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45304
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90311
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45303
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79731
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19966
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},
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1646
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876
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},
{
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45303
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45303
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90322
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45303
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90325
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45303
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},
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90323
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45303
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},
{
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1663
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871,
873,
45303
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1658
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871,
45303
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},
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"dataPointInteractionIds": [
1659
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"refIds": [
871,
45303
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},
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"dataPointInteractionIds": [
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45303
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},
{
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"dataPointInteractionIds": [
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"refIds": [
871,
45303
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{
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77203
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"refIds": [
902
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},
{
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"dataPointInteractionIds": [
77205
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"refIds": [
902
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},
{
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1680
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879,
45304
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},
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1688
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879,
45304
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1672
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871,
45304
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"dataPointInteractionIds": [
1682
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858,
45304
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},
{
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"dataPointInteractionIds": [
90354
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45303
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},
{
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"dataPointInteractionIds": [
1713
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"refIds": [
888
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},
{
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"dataPointInteractionIds": [
90350
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45303
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},
{
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90357
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45303
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{
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90356
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45303
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90351
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45303
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1707
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871,
45303
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89599
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45303
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},
{
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1697
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"refIds": [
871,
28114,
45303
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1712
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"refIds": [
888
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
1693
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"refIds": [
888
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},
{
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"affinity": "5.6 - 7.3",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90355
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"refIds": [
45303
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},
{
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"affinity": "5.3 - 6.4",
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"dataPointInteractionIds": [
1711
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871,
873,
45303
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},
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"dataPointInteractionIds": [
1725
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"refIds": [
871,
45304
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},
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"dataPointInteractionIds": [
1736
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"refIds": [
858,
45304
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},
{
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"dataPointInteractionIds": [
90361
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45304
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},
{
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79732
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19966
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},
{
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"dataPointInteractionIds": [
90394
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45309
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},
{
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90415,
90416,
90417
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45309
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{
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90395
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45309
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},
{
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"affinity": "7.6 - 9.5",
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"dataPointInteractionIds": [
90408,
90409,
90407
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45309,
45309
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},
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"affinity": "6.5 - 9.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
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90420,
90419
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45309,
45309
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"affinity": "8.3 - 9.1",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
90413,
90412
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"refIds": [
945,
45309
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{
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90386
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90390,
90392
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90453
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1802
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69
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{
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35070,
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90496
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90491
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45310
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45310
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1811
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45310
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{
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{
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14875
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14875
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14875
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14865
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"refIds": [
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{
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90546
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{
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46740
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1880
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1881
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46740
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{
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{
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{
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},
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},
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},
{
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14875
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},
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1051,
14875
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},
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1910
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1022,
1051,
1067
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},
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14875
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},
{
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},
{
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},
{
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1923
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1067
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},
{
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1916
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1067
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},
{
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1067
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},
{
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1917
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1067
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
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"refIds": [
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},
{
"targetId": 30,
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"affinity": "6.2 - 6.3",
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"dataPointInteractionIds": [
1921
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"refIds": [
990,
992
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},
{
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"affinity": "5.7 - 7.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
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"refIds": [
14875,
40016
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},
{
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"affinity": "5.6 - 7.4",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
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14875
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
90581
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14875
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},
{
"targetId": 32,
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
84131
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"refIds": [
32151
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},
{
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"affinity": "9.0 - 9.3",
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"dataPointInteractionIds": [
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"refIds": [
1172,
1173,
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
91685
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"refIds": [
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},
{
"targetId": 35,
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"affinityParameter": "pKd",
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1953
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"refIds": [
1172,
1244,
1247
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},
{
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"affinity": "8.3",
"affinityParameter": "pEC50",
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"refIds": [
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},
{
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24560
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},
{
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"affinity": "",
"affinityParameter": "",
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},
{
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"affinity": "9.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
2113
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"refIds": [
1693
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},
{
"targetId": 44,
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"affinity": "8.1",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
89500
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"refIds": [
45080
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},
{
"targetId": 45,
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"affinity": "8.6 - 8.9",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
81032
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"refIds": [
24560
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},
{
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
79791
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"refIds": [
24560
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},
{
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"affinity": "",
"affinityParameter": "",
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89501
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},
{
"targetId": 46,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2131
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"refIds": [
1693
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},
{
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"affinity": "8.3 - 9.1",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
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"refIds": [
50060
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},
{
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"affinityParameter": "pKB",
"dataPointInteractionIds": [
85820
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"refIds": [
45081
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},
{
"targetId": 48,
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"affinity": "10.7",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
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"refIds": [
41967
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},
{
"targetId": 48,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
84718
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"refIds": [
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},
{
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87980
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"refIds": [
41966
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},
{
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82213
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"refIds": [
27755
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},
{
"targetId": 54,
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"ligandId": 12235,
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"affinityParameter": "pIC50",
"dataPointInteractionIds": [
88963
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44305
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},
{
"targetId": 56,
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"dataPointInteractionIds": [
83453
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30723
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},
{
"targetId": 56,
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"ligandId": 4150,
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"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
84111
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"refIds": [
32074
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},
{
"targetId": 56,
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2218
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1941,
1956,
1957,
16332
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},
{
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30723
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
2221
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1940,
1941,
1976,
1977
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{
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},
{
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},
{
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13925
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15028,
18070
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{
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91454
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{
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{
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83566
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30945
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{
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2532
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2770,
24739
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24264
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},
{
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24341
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},
{
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83686
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31075
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},
{
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79693
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24428
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},
{
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80137
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},
{
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80139
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25271
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},
{
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79947
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65
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},
{
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24264
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},
{
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83503
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"refIds": [
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30815
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},
{
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83684
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24726
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},
{
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},
{
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},
{
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2829
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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"refIds": [
24428
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},
{
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},
{
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2604
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"refIds": [
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2828
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},
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80138
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},
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},
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2628
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2822
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},
{
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77243
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2825
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},
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24264
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},
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43584
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},
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23525
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},
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},
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80027
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24813
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},
{
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79593
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24341
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},
{
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"refIds": [
24726
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},
{
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},
{
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85523
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31249
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},
{
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},
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3121
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45088
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14946
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2734
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3191,
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38901
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91704
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49248
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},
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},
{
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41453
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"affinity": "7.6",
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91371
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49224
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{
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"affinity": "7.7",
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24216
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},
{
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"affinity": "10.5",
"affinityParameter": "pEC50",
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91912
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50725
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},
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91372
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49224
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},
{
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91370
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49224
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},
{
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"affinityParameter": "pEC50",
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91373
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49224
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},
{
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"dataPointInteractionIds": [
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31772
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},
{
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9039
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{
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31772
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},
{
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31771,
31772
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},
{
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},
{
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31771
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},
{
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14025
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18364
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},
{
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89019
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44421
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},
{
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89020
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44421
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},
{
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{
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88979
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44318,
44319
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},
{
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79698
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24428
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},
{
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79975
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24716
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},
{
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83300
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28141
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},
{
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"affinityParameter": "pKi",
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88064
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42388
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},
{
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88656
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43584
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},
{
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84299
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32864
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},
{
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85611
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36243
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},
{
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85614
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36247
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},
{
"targetId": 263,
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83313
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28141
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},
{
"targetId": 263,
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"dataPointInteractionIds": [
3010
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"refIds": [
4080
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},
{
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"affinityParameter": "pKi",
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3014
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4080
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},
{
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83324
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28141
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},
{
"targetId": 270,
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"dataPointInteractionIds": [
77793
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"refIds": [
37315
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},
{
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77795
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37315
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},
{
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"dataPointInteractionIds": [
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77792
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20981
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},
{
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},
{
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"affinityParameter": "pIC50",
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},
{
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"refIds": [
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},
{
"targetId": 275,
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"affinityParameter": "pEC50",
"dataPointInteractionIds": [
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40917
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},
{
"targetId": 275,
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"affinity": "9.2",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
87669
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40917
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},
{
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"affinity": "5.0",
"affinityParameter": "pEC50",
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84224
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"refIds": [
32471
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},
{
"targetId": 277,
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"affinity": "5.0",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
84225
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32471
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31744
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83863
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31714
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83888
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31744
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{
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4375
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83756
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31400
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},
{
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37855
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},
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79721
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4375
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},
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83757
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31400
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},
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86504
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37855
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},
{
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79723
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24470
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},
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86506
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"refIds": [
37855,
41511
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},
{
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83755
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31400
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},
{
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83754
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31400,
41510
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},
{
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79722
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4375
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},
{
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83758
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31400
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},
{
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86507
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"refIds": [
37855
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},
{
"targetId": 293,
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86043
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"refIds": [
37030
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},
{
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78386
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22057
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},
{
"targetId": 310,
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3739
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5191,
5198
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},
{
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3756
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5216,
5225
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},
{
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81921
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27393
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},
{
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"dataPointInteractionIds": [
79417
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24263
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},
{
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79403
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24254
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},
{
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79778
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24536
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},
{
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79989
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24254
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},
{
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87043
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38716
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},
{
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80167
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25330
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},
{
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86295
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37556
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},
{
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81922
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24254
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},
{
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79416
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24263
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},
{
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79401
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"refIds": [
24253
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},
{
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79404
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24254
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},
{
"targetId": 318,
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83422
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30644
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},
{
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3845
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"refIds": [
5375,
49996
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},
{
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79779
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24536
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},
{
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79990
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24254
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},
{
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87044
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38716
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},
{
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81923
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24254
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80168
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25330
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},
{
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80169
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25330
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},
{
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3943
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5246
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{
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87042
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38716
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},
{
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37269
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},
{
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"dataPointInteractionIds": [
89215
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"refIds": [
44839
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},
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"affinityParameter": "pKi",
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89440
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44839
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},
{
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
89453
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42598
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88165
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42598
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},
{
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89444
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37269
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},
{
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89441
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37269,
44839
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},
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"dataPointInteractionIds": [
89436
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43287
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},
{
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89437
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43287
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},
{
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89447
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44839
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},
{
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"dataPointInteractionIds": [
89214
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42598,
44839
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},
{
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"dataPointInteractionIds": [
89445
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44839
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},
{
"targetId": 322,
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"affinity": "9.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
89455
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42598
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},
{
"targetId": 322,
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"selectivity": "Not Determined",
"affinity": "8.3",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
89449
],
"refIds": [
44839
]
},
{
"targetId": 322,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "9.2",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
89448
],
"refIds": [
44839
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},
{
"targetId": 322,
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"ligandId": 11648,
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"selectivity": "Not Determined",
"affinity": "8.8",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
89438
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"refIds": [
44839
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},
{
"targetId": 322,
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"affinity": "9.0",
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"dataPointInteractionIds": [
89446
],
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44839
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},
{
"targetId": 322,
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"selectivity": "Not Determined",
"affinity": "9.2",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
89439
],
"refIds": [
43287
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},
{
"targetId": 323,
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"ligandId": 1728,
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "5.3",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4018
],
"refIds": [
5693
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},
{
"targetId": 324,
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"affinity": "4.3",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
4031
],
"refIds": [
5692,
5752
]
},
{
"targetId": 326,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1728,
"ligandName": "suramin",
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"affinity": "4.0",
"affinityParameter": "pKB",
"dataPointInteractionIds": [
84167
],
"refIds": [
32301
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},
{
"targetId": 327,
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"ligandName": "suramin",
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"action": "Antagonist",
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"affinity": "4.8 - 6.0",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
4076
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"refIds": [
5801
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},
{
"targetId": 329,
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"primaryTarget": false,
"ligandId": 1776,
"ligandName": "cangrelor",
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"action": "Antagonist",
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"affinity": "8.3",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
4102
],
"refIds": [
5856
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},
{
"targetId": 334,
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"primaryTarget": false,
"ligandId": 10103,
"ligandName": "rupatadine",
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"action": "Antagonist",
"selectivity": "Not Determined",
"affinity": "5.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
85613
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"refIds": [
28072
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},
{
"targetId": 338,
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"primaryTarget": false,
"ligandId": 1895,
"ligandName": "iloprost",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "6.0 - 6.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4272
],
"refIds": [
6188,
6205,
19374
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},
{
"targetId": 338,
"targetName": "DP1 receptor",
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"primaryTarget": false,
"ligandId": 5820,
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"selectivity": "Not Determined",
"affinity": "8.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80897
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"refIds": [
19374,
31453,
50035
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},
{
"targetId": 340,
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"targetSpecies": "Human",
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"ligandId": 5820,
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"action": "Full agonist",
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"affinity": "6.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80895
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"refIds": [
19374
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},
{
"targetId": 340,
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"targetSpecies": "Mouse",
"primaryTarget": false,
"ligandId": 1882,
"ligandName": "PGE1",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "7.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4322
],
"refIds": [
6202
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},
{
"targetId": 341,
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"ligandId": 10315,
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
86189
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"refIds": [
37378
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},
{
"targetId": 341,
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"ligandId": 5820,
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"affinity": "8.4",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
80896
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"refIds": [
19374,
31453
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},
{
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"ligandId": 1882,
"ligandName": "PGE1",
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"selectivity": "Not Determined",
"affinity": "8.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4376
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"refIds": [
6202
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},
{
"targetId": 341,
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"ligandId": 1882,
"ligandName": "PGE1",
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"selectivity": "Not Determined",
"affinity": "8.0",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4375
],
"refIds": [
6224
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},
{
"targetId": 341,
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"primaryTarget": false,
"ligandId": 1883,
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"selectivity": "Not Determined",
"affinity": "8.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4379
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"refIds": [
6224
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},
{
"targetId": 342,
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"ligandId": 1883,
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"action": "Full agonist",
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"affinity": "8.2 - 9.1",
"affinityParameter": "pKd",
"dataPointInteractionIds": [
76955
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"refIds": [
6204,
19374,
19375
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},
{
"targetId": 342,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1883,
"ligandName": "PGE2",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "9.5",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
76954
],
"refIds": [
6205
]
},
{
"targetId": 342,
"targetName": "EP3 receptor",
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"targetSpecies": "Mouse",
"primaryTarget": false,
"ligandId": 1883,
"ligandName": "PGE2",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "8.9",
"affinityParameter": "pKd",
"dataPointInteractionIds": [
76978
],
"refIds": [
6202
]
},
{
"targetId": 342,
"targetName": "EP3 receptor",
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"targetSpecies": "Mouse",
"primaryTarget": false,
"ligandId": 1883,
"ligandName": "PGE2",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4418
],
"refIds": [
6202
]
},
{
"targetId": 343,
"targetName": "EP4 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1882,
"ligandName": "PGE1",
"type": "Agonist",
"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "9.5",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
77068
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"refIds": [
19501
]
},
{
"targetId": 343,
"targetName": "EP4 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1882,
"ligandName": "PGE1",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "8.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4468
],
"refIds": [
6412
]
},
{
"targetId": 343,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1883,
"ligandName": "PGE2",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "8.1 - 9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4470
],
"refIds": [
6204,
6205,
6336,
6412,
19505
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},
{
"targetId": 344,
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 9635,
"ligandName": "latanoprostene bunod",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.6",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84471
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"refIds": [
6205,
33427
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},
{
"targetId": 345,
"targetName": "IP receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1915,
"ligandName": "PGI2",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "7.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
84146
],
"refIds": [
32248
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},
{
"targetId": 345,
"targetName": "IP receptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 7552,
"ligandName": "selexipag",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "5.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
83781
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"refIds": [
19469
]
},
{
"targetId": 345,
"targetName": "IP receptor",
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"affinityParameter": "pKi",
"dataPointInteractionIds": [
83778
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"refIds": [
19469
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},
{
"targetId": 345,
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"targetSpecies": "Human",
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"ligandId": 1882,
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"action": "Full agonist",
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"affinity": "6.5 - 6.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
78811
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"refIds": [
23120,
31462
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},
{
"targetId": 356,
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"ligandId": 14237,
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"selectivity": "Not Determined",
"affinity": "9.6",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
91854
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"refIds": [
50516
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},
{
"targetId": 356,
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"targetSpecies": "Rat",
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"ligandId": 14237,
"ligandName": "paltusotine",
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"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "8.9",
"affinityParameter": "pEC50",
"dataPointInteractionIds": [
91855
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"refIds": [
50516
]
},
{
"targetId": 356,
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"ligandId": 5638,
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"selectivity": "Not Determined",
"affinity": "8.6",
"affinityParameter": "pIC50",
"dataPointInteractionIds": [
14341
],
"refIds": [
18671
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},
{
"targetId": 356,
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"targetSpecies": "Mouse",
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"ligandId": 2031,
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"selectivity": "Not Determined",
"affinity": "6.9 - 9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4643
],
"refIds": [
6649
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},
{
"targetId": 356,
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"targetSpecies": "Mouse",
"primaryTarget": false,
"ligandId": 2054,
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "6.1 - 9.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4693
],
"refIds": [
6649
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},
{
"targetId": 356,
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"targetSpecies": "Mouse",
"primaryTarget": false,
"ligandId": 2055,
"ligandName": "octreotide",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "7.5 - 9.2",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4696
],
"refIds": [
6649
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},
{
"targetId": 356,
"targetName": "SST2 receptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 2031,
"ligandName": "lanreotide",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "8.8",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4644
],
"refIds": [
6649
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},
{
"targetId": 356,
"targetName": "SST2 receptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 2054,
"ligandName": "vapreotide",
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"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "9.1",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4692
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"refIds": [
6649
]
},
{
"targetId": 356,
"targetName": "SST2 receptor",
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"targetSpecies": "Rat",
"primaryTarget": false,
"ligandId": 2055,
"ligandName": "octreotide",
"type": "Agonist",
"action": "Full agonist",
"selectivity": "Not Determined",
"affinity": "8.7",
"affinityParameter": "pKi",
"dataPointInteractionIds": [
4695
],
"refIds": [
6649
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},
{
"targetId": 356,
"targetName": "SST2 receptor",
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"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 2055,
"ligandName": "octreotide",
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"action": "Full agonist",
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{
"targetId": 3315,
"targetName": "TAS2R2",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 14052,
"ligandName": "chlorhexidine",
"type": "Agonist",
"action": "Agonist",
"selectivity": "Not Determined",
"affinity": "",
"affinityParameter": "",
"dataPointInteractionIds": [
91562
],
"refIds": [
49731
]
}
]