{
    "comments": "Daptomycin is a cyclic lipopeptide antibacterial with broad-spectrum activity against Gram-positive bacteria <Reference id=51707/>. It is a bacterial metabolite that was isolated from <i>Streptomyces roseosporus</i> <Reference id=51708/>. Daptomycin rapidly depolarizes the bacterial cell membrane which disrupts DNA, RNA and protein synthesis and results in cell death.",
    "bioactivityComments": "MIC90 for antibacterial activity against erythromycin-nonsusceptible <i>Streptococcus pyogenes</i> is &le;30 ng/ml <i>in vitro</i> <Reference id=39448/>.",
    "clinicalUse": "Daptomycin is used to treat complicated bacterial infections of the skin and soft tissues, <i>Staphylococcus aureus</i> bacteraemia, and MRSA. It was removed from the World Health Organization's List of Essential Medicines in 2019, as it did not meet the revised criteria for inclusion on the Model Lists as a Reserve group agent <Reference id=51627/>.",
    "mechanismOfAction": "",
    "absorptionAndDistribution": "",
    "metabolism": "",
    "elimination": "",
    "populationPharmacokinetics": "",
    "organFunctionImpairment": "",
    "immuno": "",
    "gtmp": ""
}