[
    {
        "interactionId": 3202,
        "targetId": 282,
        "targetName": "MC<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 1323,
        "ligandName": "MT-II",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "9.4",
        "affinityParameter": "pIC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 4327,
                "pmid": 12007532,
                "type": "Journal",
                "title": "Eur J Pharmacol",
                "year": 2002,
                "volume": "440",
                "issue": "2-3",
                "pages": "141-57",
                "articleTitle": "The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.",
                "authors": "MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ <i>et al.</i>"
            },
            {
                "referenceId": 4330,
                "pmid": 2535874,
                "type": "Journal",
                "title": "J Med Chem",
                "year": 1989,
                "volume": "32",
                "pages": "174-179",
                "articleTitle": "Design of potent linear &alpha;-melanotropin 4-10 analogues modified in positions 5 and 10.",
                "authors": "Al-Obeidi F, Hruby VJ, Castrucci AM, Hadley ME"
            }
        ]
    },
    {
        "interactionId": 3216,
        "targetId": 284,
        "targetName": "MC<sub>3</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 1323,
        "ligandName": "MT-II",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "8.3",
        "affinityParameter": "pKi",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 4359,
                "pmid": 10493100,
                "type": "Journal",
                "title": "Eur J Pharmacol",
                "year": 1999,
                "volume": "378",
                "pages": "249-258",
                "articleTitle": "Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.",
                "authors": "Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH"
            }
        ]
    },
    {
        "interactionId": 3226,
        "targetId": 285,
        "targetName": "MC<sub>4</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 1323,
        "ligandName": "MT-II",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "8.2 - 8.8",
        "affinityParameter": "pKi",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 4330,
                "pmid": 2535874,
                "type": "Journal",
                "title": "J Med Chem",
                "year": 1989,
                "volume": "32",
                "pages": "174-179",
                "articleTitle": "Design of potent linear &alpha;-melanotropin 4-10 analogues modified in positions 5 and 10.",
                "authors": "Al-Obeidi F, Hruby VJ, Castrucci AM, Hadley ME"
            },
            {
                "referenceId": 4359,
                "pmid": 10493100,
                "type": "Journal",
                "title": "Eur J Pharmacol",
                "year": 1999,
                "volume": "378",
                "pages": "249-258",
                "articleTitle": "Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.",
                "authors": "Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH"
            },
            {
                "referenceId": 4371,
                "pmid": 11101306,
                "type": "Journal",
                "title": "Biochemistry",
                "year": 2000,
                "volume": "39",
                "issue": "48",
                "pages": "14900-11",
                "articleTitle": "Molecular determinants of ligand binding to the human melanocortin-4 receptor.",
                "authors": "Yang YK, Fong TM, Dickinson CJ, Mao C, Li JY, Tota MR, Mosley R, Van Der Ploeg LH, Gantz I"
            }
        ]
    },
    {
        "interactionId": 3240,
        "targetId": 286,
        "targetName": "MC<sub>5</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 1323,
        "ligandName": "MT-II",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "9.0",
        "affinityParameter": "pIC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 4327,
                "pmid": 12007532,
                "type": "Journal",
                "title": "Eur J Pharmacol",
                "year": 2002,
                "volume": "440",
                "issue": "2-3",
                "pages": "141-57",
                "articleTitle": "The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.",
                "authors": "MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ <i>et al.</i>"
            }
        ]
    }
]