{
    "comments": "Nesiritide is the recombinant form of human brain natriuretic peptide.",
    "bioactivityComments": "There appears to be no publicly available bioactivity data for this drug at its human molecular target.",
    "clinicalUse": "Nesiritide is used to relaxe and dilate blood vessels, lowering blood pressure. The drug is also used to improve breathing in patients with congestive heart failure.",
    "mechanismOfAction": "In its natural form, the endogenous peptide BNP binds to the guanylate cyclase receptor in vascular smooth muscle and endothelial cells. This leads to the relaxation of smooth muscle through increasing intracellular concentrations of guanosine 3'5'-cyclic monophosphate. This in turn leads to the dilation of veins and arteries.",
    "absorptionAndDistribution": "",
    "metabolism": "",
    "elimination": "",
    "populationPharmacokinetics": "",
    "organFunctionImpairment": "",
    "immuno": "",
    "gtmp": ""
}