{
    "comments": "Ularitide is a synthetic 32 amino acid peptidomimetic of human urodilatin (atrial natriuretic peptide (95-126)).",
    "bioactivityComments": "",
    "clinicalUse": "Ularitide is being evaluated in Phase 3 clinical trial as a potential treatment for acute heart failure <Reference id=28067/><Reference id=28068/>.",
    "mechanismOfAction": "Urodilatin is a kidney specific fragment of ANP. Urodilatin induces strong diuresis and natriuresis, being invloved in the regulation of body fluid volume and water-electrolyte excretion. Ularitide effectively mimics ANP's inhibitory action on the renin-angiotensin-aldosterone system which is activated early in the development of congestive heart failure (CHF) to stimulate water excretion <i>via</i> the kidneys <Reference id=28068/>.",
    "absorptionAndDistribution": "",
    "metabolism": "",
    "elimination": "",
    "populationPharmacokinetics": "",
    "organFunctionImpairment": "",
    "immuno": "",
    "gtmp": ""
}