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        "ligandId": 9734,
        "ligandName": "liver enriched antimicrobial peptide 2",
        "ligandContext": "",
        "endogenous": true,
        "type": "Antagonist",
        "action": "Antagonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "8.2",
        "affinityParameter": "pIC50",
        "originalAffinity": "6x10<sup>-9</sup>",
        "originalAffinityType": "IC50",
        "originalAffinityRelation": "=",
        "assayDescription": "IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
            {
                "referenceId": 33916,
                "pmid": 29233536,
                "type": "Journal",
                "title": "Cell Metab",
                "year": 2018,
                "volume": "27",
                "issue": "2",
                "pages": "461-469.e6",
                "articleTitle": "LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.",
                "authors": "Ge X, Yang H, Bednarek MA, Galon-Tilleman H, Chen P, Chen M, Lichtman JS, Wang Y, Dalmas O, Yin Y <i>et al.</i>",
                "pubStatus": "",
                "doi": ""
            }
        ]
    },
    {
        "interactionId": 91882,
        "targetId": 246,
        "targetName": "ghrelin receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 14259,
        "ligandName": "[<sup>18</sup>F]AQ-12",
        "ligandContext": "",
        "endogenous": false,
        "type": "Antagonist",
        "action": "Antagonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "8.3",
        "affinityParameter": "pKi",
        "originalAffinity": "4.73x10<sup>-9</sup>",
        "originalAffinityType": "Ki",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 50635,
                "pmid": 41143350,
                "type": "Journal",
                "title": "J Med Chem",
                "year": 2025,
                "volume": "68",
                "issue": "21",
                "pages": "22288-22300",
                "articleTitle": "Structure-Activity Relationships of Azaquinazolinone Derivatives as <sup>18</sup>F-Labeled PET Probes Targeting Ghrelin Receptors.",
                "authors": "Watanabe H, Saito H, Nakashima K, Ono M"
            }
        ]
    }
]