[
    {
        "targetId": 282,
        "transducers": "G<sub>s</sub> family",
        "effectors": "Adenylyl cyclase stimulation",
        "comments": "",
        "secondaryMechanism": false,
        "refs": [
            {
                "referenceId": 4309,
                "pmid": 8187950,
                "type": "Journal",
                "title": "Mol Cell Endocrinol",
                "year": 1994,
                "volume": "99",
                "issue": "1",
                "pages": "R17-20",
                "articleTitle": "ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines.",
                "authors": "Mountjoy KG, Bird IM, Rainey WE, Cone RD"
            }
        ]
    },
    {
        "targetId": 282,
        "transducers": "G protein (identity unknown)",
        "effectors": "Other - See Comments",
        "comments": "Melanocortin activation of the murine MC<sub>1</sub>R mobilizes intracellular calcium <i>via</i> an incompletely understood pathway.<br>Alternative rescue transduction mechanism: (transducer unknown, effector/response protein kinase B (Akt)). This pathway is only activated when there is insufficient production of cAMP due to loss of function mutations and is currently associated with only the protective activity against cancer.",
        "secondaryMechanism": true,
        "refs": [
            {
                "referenceId": 40253,
                "pmid": 29622793,
                "type": "Journal",
                "title": "Oncogene",
                "year": 2018,
                "volume": "37",
                "issue": "27",
                "pages": "3631-3646",
                "articleTitle": "cAMP-independent non-pigmentary actions of variant melanocortin 1 receptor: AKT-mediated activation of protective responses to oxidative DNA damage.",
                "authors": "Castejón-Griñán M, Herraiz C, Olivares C, Jiménez-Cervantes C, García-Borrón JC",
                "pubStatus": "",
                "doi": ""
            },
            {
                "referenceId": 4313,
                "pmid": 11161002,
                "type": "Journal",
                "title": "Physiol Genomics",
                "year": 2001,
                "volume": "5",
                "issue": "1",
                "pages": "11-9",
                "articleTitle": "Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells.",
                "authors": "Mountjoy KG, Kong PL, Taylor JA, Willard DH, Wilkison WO"
            }
        ]
    }
]