[
{
"interactionId": 8973,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 3804,
"ligandName": "[125I]SHU9119",
"ligandContext": "",
"endogenous": false,
"type": "Antagonist",
"action": "Antagonist",
"actionComment": "",
"selectivity": "Not Determined",
"concentrationRange": "",
"affinity": "9.2",
"affinityParameter": "pKd",
"originalAffinity": "7x10-10",
"originalAffinityType": "Kd",
"originalAffinityRelation": "=",
"assayDescription": "",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": true,
"refs": [
{
"referenceId": 19183,
"pmid": 12604699,
"type": "Journal",
"title": "J Pharmacol Exp Ther",
"year": 2003,
"volume": "304",
"issue": "3",
"pages": "1217-27",
"articleTitle": "Molecular determinants of melanocortin 4 receptor ligand binding and MC4/MC3 receptor selectivity.",
"authors": "Nickolls SA, Cismowski MI, Wang X, Wolff M, Conlon PJ, Maki RA",
"pubStatus": ""
}
]
},
{
"interactionId": 79723,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 3633,
"ligandName": "ACTH",
"ligandContext": "",
"endogenous": false,
"type": "Agonist",
"action": "Agonist",
"actionComment": "",
"selectivity": "Not Determined",
"concentrationRange": "",
"affinity": "6.2",
"affinityParameter": "pKi",
"originalAffinity": "6.93x10-7",
"originalAffinityType": "Ki",
"originalAffinityRelation": "=",
"assayDescription": "",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 24470,
"pmid": 8884876,
"type": "Journal",
"title": "Pharmacol Toxicol",
"year": 1996,
"volume": "79",
"issue": "3",
"pages": "161-5",
"articleTitle": "Characterisation of the melanocortin 4 receptor by radioligand binding.",
"authors": "Schiöth HB, Muceniece R, Wikberg JE",
"pubStatus": ""
}
]
},
{
"interactionId": 83754,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 9272,
"ligandName": "setmelanotide",
"ligandContext": "",
"endogenous": false,
"type": "Agonist",
"action": "Agonist",
"actionComment": "",
"selectivity": "Selective",
"concentrationRange": "",
"affinity": "8.7",
"affinityParameter": "pKi",
"originalAffinity": "2.1x10-9",
"originalAffinityType": "Ki",
"originalAffinityRelation": "=",
"assayDescription": "",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": true,
"refs": [
{
"referenceId": 31400,
"pmid": 19646498,
"type": "Journal",
"title": "Peptides",
"year": 2009,
"volume": "30",
"issue": "10",
"pages": "1892-900",
"articleTitle": "Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.",
"authors": "Kumar KG, Sutton GM, Dong JZ, Roubert P, Plas P, Halem HA, Culler MD, Yang H, Dixit VD, Butler AA",
"pubStatus": ""
},
{
"referenceId": 41510,
"pmid": 33137293,
"type": "Journal",
"title": "Lancet Diabetes Endocrinol",
"year": 2020,
"volume": "8",
"issue": "12",
"pages": "960-970",
"articleTitle": "Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.",
"authors": "Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G et al.",
"pubStatus": "",
"doi": ""
}
]
},
{
"interactionId": 3230,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 1326,
"ligandName": "[125I]NDP-MSH",
"ligandContext": "",
"endogenous": false,
"type": "Agonist",
"action": "Full agonist",
"actionComment": "",
"selectivity": "Not Determined",
"concentrationRange": "",
"affinity": "8.4 - 8.9",
"affinityParameter": "pKd",
"originalAffinity": "4x10-9 - 1.2x10-9",
"originalAffinityType": "Kd",
"originalAffinityRelation": "=",
"assayDescription": "",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": true,
"refs": [
{
"referenceId": 4333,
"pmid": 15840392,
"type": "Journal",
"title": "Eur J Pharmacol",
"year": 2005,
"volume": "512",
"issue": "2-3",
"pages": "85-95",
"articleTitle": "Co-operative regulation of ligand binding to melanocortin receptor subtypes: evidence for interacting binding sites.",
"authors": "Kopanchuk S, Veiksina S, Petrovska R, Mutule I, Szardenings M, Rinken A, Wikberg JE"
},
{
"referenceId": 4375,
"pmid": 7774675,
"type": "Journal",
"title": "Eur J Pharmacol",
"year": 1995,
"volume": "288",
"issue": "3",
"pages": "311-317",
"articleTitle": "Characterisation of melanocortin receptor subtypes by radioligand binding analysis.",
"authors": "Schioth HB, Muceniece R, Wikberg JE, Chhajlani V",
"pubStatus": ""
}
]
},
{
"interactionId": 3234,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 1339,
"ligandName": "MBP10",
"ligandContext": "",
"endogenous": false,
"type": "Antagonist",
"action": "Antagonist",
"actionComment": "",
"selectivity": "Selective",
"concentrationRange": "",
"affinity": "10.0",
"affinityParameter": "pIC50",
"originalAffinity": "1x10-10",
"originalAffinityType": "IC50",
"originalAffinityRelation": "=",
"assayDescription": "",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": true,
"refs": [
{
"referenceId": 4378,
"pmid": 11606131,
"type": "Journal",
"title": "J Med Chem",
"year": 2001,
"volume": "44",
"issue": "22",
"pages": "3665-72",
"articleTitle": "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.",
"authors": "Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH"
}
]
},
{
"interactionId": 86506,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 10408,
"ligandName": "bremelanotide",
"ligandContext": "",
"endogenous": false,
"type": "Agonist",
"action": "Agonist",
"actionComment": "",
"selectivity": "Not Determined",
"concentrationRange": "",
"affinity": "9.6",
"affinityParameter": "pKi",
"originalAffinity": "2.5x10-10",
"originalAffinityType": "Ki",
"originalAffinityRelation": "=",
"assayDescription": "Inhibition of 125I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC4 receptor.",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 37855,
"pmid": 22335602,
"type": "Journal",
"title": "J Med Chem",
"year": 2012,
"volume": "55",
"issue": "5",
"pages": "1969-77",
"articleTitle": "Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues.",
"authors": "Conde-Frieboes K, Thøgersen H, Lau JF, Sensfuss U, Hansen TK, Christensen L, Spetzler J, Olsen HB, Nilsson C, Raun K et al.",
"pubStatus": "",
"doi": ""
},
{
"referenceId": 41511,
"pmid": 31599840,
"type": "Journal",
"title": "Obstet Gynecol",
"year": 2019,
"volume": "134",
"issue": "5",
"pages": "899-908",
"articleTitle": "Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials.",
"authors": "Kingsberg SA, Clayton AH, Portman D, Williams LA, Krop J, Jordan R, Lucas J, Simon JA",
"pubStatus": "",
"doi": ""
}
]
},
{
"interactionId": 3225,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1320,
"ligandName": "α-MSH",
"endogenous": true,
"type": "Agonist",
"action": "Full agonist",
"concentrationRange": "",
"affinity": "7.4 - 8.0",
"affinityParameter": "pKi",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4359,
"pmid": 10493100,
"type": "Journal",
"title": "Eur J Pharmacol",
"year": 1999,
"volume": "378",
"pages": "249-258",
"articleTitle": "Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.",
"authors": "Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH"
},
{
"referenceId": 4371,
"pmid": 11101306,
"type": "Journal",
"title": "Biochemistry",
"year": 2000,
"volume": "39",
"issue": "48",
"pages": "14900-11",
"articleTitle": "Molecular determinants of ligand binding to the human melanocortin-4 receptor.",
"authors": "Yang YK, Fong TM, Dickinson CJ, Mao C, Li JY, Tota MR, Mosley R, Van Der Ploeg LH, Gantz I"
}
]
},
{
"interactionId": 3226,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1323,
"ligandName": "MT-II",
"endogenous": false,
"type": "Agonist",
"action": "Full agonist",
"concentrationRange": "",
"affinity": "8.2 - 8.8",
"affinityParameter": "pKi",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4330,
"pmid": 2535874,
"type": "Journal",
"title": "J Med Chem",
"year": 1989,
"volume": "32",
"pages": "174-179",
"articleTitle": "Design of potent linear α-melanotropin 4-10 analogues modified in positions 5 and 10.",
"authors": "Al-Obeidi F, Hruby VJ, Castrucci AM, Hadley ME"
},
{
"referenceId": 4359,
"pmid": 10493100,
"type": "Journal",
"title": "Eur J Pharmacol",
"year": 1999,
"volume": "378",
"pages": "249-258",
"articleTitle": "Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.",
"authors": "Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH"
},
{
"referenceId": 4371,
"pmid": 11101306,
"type": "Journal",
"title": "Biochemistry",
"year": 2000,
"volume": "39",
"issue": "48",
"pages": "14900-11",
"articleTitle": "Molecular determinants of ligand binding to the human melanocortin-4 receptor.",
"authors": "Yang YK, Fong TM, Dickinson CJ, Mao C, Li JY, Tota MR, Mosley R, Van Der Ploeg LH, Gantz I"
}
]
},
{
"interactionId": 3227,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1324,
"ligandName": "afamelanotide",
"endogenous": false,
"type": "Agonist",
"action": "Full agonist",
"concentrationRange": "",
"affinity": "8.5 - 8.8",
"affinityParameter": "pKi",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4359,
"pmid": 10493100,
"type": "Journal",
"title": "Eur J Pharmacol",
"year": 1999,
"volume": "378",
"pages": "249-258",
"articleTitle": "Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.",
"authors": "Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH"
},
{
"referenceId": 4371,
"pmid": 11101306,
"type": "Journal",
"title": "Biochemistry",
"year": 2000,
"volume": "39",
"issue": "48",
"pages": "14900-11",
"articleTitle": "Molecular determinants of ligand binding to the human melanocortin-4 receptor.",
"authors": "Yang YK, Fong TM, Dickinson CJ, Mao C, Li JY, Tota MR, Mosley R, Van Der Ploeg LH, Gantz I"
},
{
"referenceId": 4372,
"pmid": 6777774,
"type": "Journal",
"title": "Proc Natl Acad Sci USA",
"year": 1980,
"volume": "77",
"issue": "10",
"pages": "5754-8",
"articleTitle": "4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.",
"authors": "Sawyer TK, Sanfilippo PJ, Hruby VJ, Engel MH, Heward CB, Burnett JB, Hadley ME"
}
]
},
{
"interactionId": 3228,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1337,
"ligandName": "RY764",
"endogenous": false,
"type": "Agonist",
"action": "Full agonist",
"concentrationRange": "",
"affinity": "8.1",
"affinityParameter": "pIC50",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4373,
"pmid": 15982875,
"type": "Journal",
"title": "Bioorg Med Chem Lett",
"year": 2005,
"volume": "15",
"issue": "15",
"pages": "3501-5",
"articleTitle": "Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist.",
"authors": "Ye Z, Guo L, Barakat KJ, Pollard PG, Palucki BL, Sebhat IK, Bakshi RK, Tang R, Kalyani RN, Vongs A et al.",
"pubStatus": "",
"doi": ""
}
]
},
{
"interactionId": 3231,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1335,
"ligandName": "agouti-related protein",
"endogenous": true,
"type": "Antagonist",
"action": "Inverse agonist",
"concentrationRange": "",
"affinity": "9.3",
"affinityParameter": "pIC50",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4376,
"pmid": 9299416,
"type": "Journal",
"title": "Biochem Biophys Res Commun",
"year": 1997,
"volume": "237",
"issue": "3",
"pages": "629-31",
"articleTitle": "ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors.",
"authors": "Fong TM, Mao C, MacNeil T, Kalyani R, Smith T, Weinberg D, Tota MR, Van der Ploeg LH"
}
]
},
{
"interactionId": 3233,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1328,
"ligandName": "HS024",
"endogenous": false,
"type": "Antagonist",
"action": "Antagonist",
"concentrationRange": "",
"affinity": "9.5",
"affinityParameter": "pKd",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4335,
"pmid": 9832440,
"type": "Journal",
"title": "Endocrinology",
"year": 1998,
"volume": "139",
"issue": "12",
"pages": "5006-14",
"articleTitle": "Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo.",
"authors": "Kask A, Mutulis F, Muceniece R, Pähkla R, Mutule I, Wikberg JE, Rägo L, Schiöth HB"
}
]
},
{
"interactionId": 3235,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1340,
"ligandName": "MCL0129",
"endogenous": false,
"type": "Antagonist",
"action": "Antagonist",
"concentrationRange": "",
"affinity": "10.1",
"affinityParameter": "pKd",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4379,
"pmid": 12538838,
"type": "Journal",
"title": "J Pharmacol Exp Ther",
"year": 2003,
"volume": "304",
"issue": "2",
"pages": "818-26",
"articleTitle": "Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor.",
"authors": "Chaki S, Hirota S, Funakoshi T, Suzuki Y, Suetake S, Okubo T, Ishii T, Nakazato A, Okuyama S"
}
]
},
{
"interactionId": 3236,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1341,
"ligandName": "PG-901",
"endogenous": false,
"type": "Antagonist",
"action": "Antagonist",
"concentrationRange": "",
"affinity": "8.1",
"affinityParameter": "pIC50",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4362,
"pmid": 12431055,
"type": "Journal",
"title": "J Med Chem",
"year": 2002,
"volume": "45",
"issue": "24",
"pages": "5287-94",
"articleTitle": "Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.",
"authors": "Grieco P, Lavecchia A, Cai M, Trivedi D, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ"
}
]
},
{
"interactionId": 3237,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"ligandId": 1325,
"ligandName": "SHU9119",
"endogenous": false,
"type": "Antagonist",
"action": "Antagonist",
"concentrationRange": "",
"affinity": "9.4 - 9.6",
"affinityParameter": "pKi",
"originalAffinity": "",
"originalAffinityType": "",
"originalAffinityRelation": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4328,
"pmid": 10657491,
"type": "Journal",
"title": "Neuropeptides",
"year": 1999,
"volume": "33",
"issue": "3",
"pages": "191-6",
"articleTitle": "Further pharmacological characterization of the selective melanocortin 4 receptor antagonist HS014: comparison with SHU9119.",
"authors": "Schiöth HB, Muceniece R, Mutulis F, Bouifrouri AA, Mutule I, Wikberg JE"
},
{
"referenceId": 4359,
"pmid": 10493100,
"type": "Journal",
"title": "Eur J Pharmacol",
"year": 1999,
"volume": "378",
"pages": "249-258",
"articleTitle": "Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.",
"authors": "Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH"
}
]
},
{
"interactionId": 3229,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 1338,
"ligandName": "THIQ",
"ligandContext": "",
"endogenous": false,
"type": "Agonist",
"action": "Full agonist",
"actionComment": "",
"selectivity": "Selective",
"concentrationRange": "",
"affinity": "8.9",
"affinityParameter": "pIC50",
"originalAffinity": "1.26x10-9",
"originalAffinityType": "IC50",
"originalAffinityRelation": "=",
"assayDescription": "",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": true,
"refs": [
{
"referenceId": 4374,
"pmid": 12361385,
"type": "Journal",
"title": " J Med Chem ",
"year": 2002,
"volume": "45",
"pages": "4589-4593",
"articleTitle": "Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.",
"authors": "Sebhat IK, Martin WJ, Ye Z, Barakat K, Mosley RT, Johnston DB, Bakshi R, Palucki B, Weinberg DH, MacNeil T, Kalyani RN, Tang R, Stearns RA, Miller RR, Tamvakopoulos C, Strack AM, McGowan E, Cashen DE, Drisko JE, Hom GJ, Howard AD, MacIntyre DE, van der Ploeg LH, Patchett AA, Nargund RP"
}
]
},
{
"interactionId": 8799,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 1321,
"ligandName": "HS014",
"ligandContext": "",
"endogenous": false,
"type": "Antagonist",
"action": "Antagonist",
"actionComment": "",
"selectivity": "Selective",
"concentrationRange": "",
"affinity": "8.5",
"affinityParameter": "pKi",
"originalAffinity": "3.2x10-9",
"originalAffinityType": "Ki",
"originalAffinityRelation": "=",
"assayDescription": "",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": true,
"refs": [
{
"referenceId": 14132,
"pmid": 9630346,
"type": "Journal",
"title": "Br J Pharmacol",
"year": 1998,
"volume": "124",
"issue": "1",
"pages": "75-82",
"articleTitle": "Discovery of novel melanocortin4 receptor selective MSH analogues.",
"authors": "Schiöth HB, Mutulis F, Muceniece R, Prusis P, Wikberg JE"
}
]
},
{
"interactionId": 3232,
"targetId": 285,
"targetName": "MC4 receptor",
"ligandAsTargetId": 0,
"targetSpecies": "Human",
"primaryTarget": false,
"targetBindingSite": "",
"ligandId": 1321,
"ligandName": "HS014",
"ligandContext": "",
"endogenous": false,
"type": "Antagonist",
"action": "Antagonist",
"actionComment": "",
"selectivity": "Selective",
"concentrationRange": "",
"affinity": "8.5",
"affinityParameter": "pKd",
"originalAffinity": "3.16x10-9",
"originalAffinityType": "Kd",
"originalAffinityRelation": "=",
"assayDescription": "",
"assayConditions": "",
"useDependent": false,
"voltageDependent": false,
"voltage": "",
"physiologicalVoltage": false,
"conciseView": false,
"refs": [
{
"referenceId": 4377,
"pmid": 10051117,
"type": "Journal",
"title": "Br J Pharmacol",
"year": 1999,
"volume": "126",
"issue": "1",
"pages": "27-34",
"articleTitle": "Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist.",
"authors": "Skuladottir GV, Jonsson L, Skarphedinsson JO, Mutulis F, Muceniece R, Raine A, Mutule I, Helgason J, Prusis P, Wikberg JE et al."
}
]
}
]