[
    {
        "targetId": 285,
        "transducers": "G<sub>s</sub> family",
        "effectors": "Adenylyl cyclase stimulation",
        "comments": "",
        "secondaryMechanism": false,
        "refs": [
            {
                "referenceId": 4351,
                "pmid": 8463333,
                "type": "Journal",
                "title": "J Biol Chem",
                "year": 1993,
                "volume": "268",
                "issue": "11",
                "pages": "8246-50",
                "articleTitle": "Molecular cloning of a novel melanocortin receptor.",
                "authors": "Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T"
            },
            {
                "referenceId": 4363,
                "pmid": 7854347,
                "type": "Journal",
                "title": "Mol Endocrinol",
                "year": 1994,
                "volume": "8",
                "issue": "10",
                "pages": "1298-308",
                "articleTitle": "Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.",
                "authors": "Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD"
            }
        ]
    },
    {
        "targetId": 285,
        "transducers": "G protein (identity unknown)",
        "effectors": "Other - See Comments",
        "comments": "Melanocortin activation of the MC<sub>4</sub> mobilizes intracellular calcium <i>via</i> an incompletely understood pathway.<br>Non-G protein dependent transduction: Effector/response inwardly rectifying potassium channel, K<sub>ir</sub>7.1  ",
        "secondaryMechanism": true,
        "refs": [
            {
                "referenceId": 30179,
                "pmid": 25600267,
                "type": "Journal",
                "title": "Nature",
                "year": 2015,
                "volume": "520",
                "issue": "7545",
                "pages": "94-8",
                "articleTitle": "G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.",
                "authors": "Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM <i>et al.</i>",
                "pubStatus": ""
            },
            {
                "referenceId": 4313,
                "pmid": 11161002,
                "type": "Journal",
                "title": "Physiol Genomics",
                "year": 2001,
                "volume": "5",
                "issue": "1",
                "pages": "11-9",
                "articleTitle": "Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells.",
                "authors": "Mountjoy KG, Kong PL, Taylor JA, Willard DH, Wilkison WO"
            }
        ]
    }
]