[
    {
        "interactionId": 85972,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 682,
        "ligandName": "&beta;-CGRP",
        "ligandContext": "",
        "endogenous": true,
        "type": "Agonist",
        "action": "None",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "",
        "affinityParameter": "",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
        ]
    },
    {
        "interactionId": 2116,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 688,
        "ligandName": "amylin",
        "ligandContext": "",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "9.0 - 10.7",
        "affinityParameter": "pEC50",
        "originalAffinity": "1.047x10<sup>-9</sup> - 1.99x10<sup>-11</sup>",
        "originalAffinityType": "EC50",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            },
            {
                "referenceId": 1687,
                "pmid": 14722252,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2004,
                "volume": "65",
                "issue": "1",
                "pages": "207-13",
                "articleTitle": "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.",
                "authors": "Kuwasako K, Cao YN, Nagoshi Y, Tsuruda T, Kitamura K, Eto T"
            },
            {
                "referenceId": 1690,
                "pmid": 11033437,
                "type": "Journal",
                "title": "J Pharmacol Toxicol Methods",
                "year": 1999,
                "volume": "42",
                "issue": "4",
                "pages": "217-24",
                "articleTitle": "Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor.",
                "authors": "Armour SL, Foord S, Kenakin T, Chen WJ"
            },
            {
                "referenceId": 24560,
                "pmid": 24169554,
                "type": "Journal",
                "title": "Endocrinology",
                "year": 2014,
                "volume": "155",
                "issue": "1",
                "pages": "21-6",
                "articleTitle": "Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors.",
                "authors": "Gingell JJ, Burns ER, Hay DL",
                "pubStatus": ""
            }
        ]
    },
    {
        "interactionId": 2108,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 681,
        "ligandName": "&alpha;-CGRP",
        "ligandContext": "",
        "endogenous": true,
        "type": "Agonist",
        "action": "Full agonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "8.7 - 10.8",
        "affinityParameter": "pEC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            },
            {
                "referenceId": 1685,
                "pmid": 11023820,
                "type": "Journal",
                "title": "Biochem J",
                "year": 2000,
                "volume": "351",
                "pages": "347-351",
                "articleTitle": "Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.",
                "authors": "Leuthauser K, Gujer R, Aldecoa A, McKinney RA, Muff R, Fischer JA, Born W"
            },
            {
                "referenceId": 1687,
                "pmid": 14722252,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2004,
                "volume": "65",
                "issue": "1",
                "pages": "207-13",
                "articleTitle": "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.",
                "authors": "Kuwasako K, Cao YN, Nagoshi Y, Tsuruda T, Kitamura K, Eto T"
            },
            {
                "referenceId": 1688,
                "pmid": 12565884,
                "type": "Journal",
                "title": "Biochem Biophys Res Commun",
                "year": 2003,
                "volume": "301",
                "issue": "2",
                "pages": "460-4",
                "articleTitle": "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.",
                "authors": "Kuwasako K, Kitamura K, Nagoshi Y, Eto T"
            },
            {
                "referenceId": 27864,
                "pmid": 26125036,
                "type": "Journal",
                "title": "Ann Clin Transl Neurol",
                "year": 2015,
                "volume": "2",
                "issue": "6",
                "pages": "595-608",
                "articleTitle": "A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.",
                "authors": "Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel PA, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL",
                "pubStatus": ""
            }
        ]
    },
    {
        "interactionId": 8936,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 3770,
        "ligandName": "[<sup>125</sup>I]amylin",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "9.0 - 10.0",
        "affinityParameter": "pKd",
        "originalAffinity": "1x10<sup>-9</sup> - 1x10<sup>-10</sup>",
        "originalAffinityType": "Kd",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
        ]
    },
    {
        "interactionId": 12671,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 700,
        "ligandName": "&alpha;-CGRP-(8-37) (human)",
        "ligandContext": "",
        "endogenous": false,
        "type": "Antagonist",
        "action": "Antagonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "6.6",
        "affinityParameter": "pKB",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            }
        ]
    },
    {
        "interactionId": 2111,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 684,
        "ligandName": "adrenomedullin 2/intermedin",
        "ligandContext": "",
        "endogenous": true,
        "type": "Agonist",
        "action": "Full agonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "8.0",
        "affinityParameter": "pEC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 14903,
                "pmid": 21658025,
                "type": "Journal",
                "title": "Br J Pharmacol",
                "year": 2012,
                "volume": "166",
                "issue": "1",
                "pages": "110-20",
                "articleTitle": "The pharmacology of adrenomedullin 2/intermedin.",
                "authors": "Hong Y, Hay DL, Quirion R, Poyner DR",
                "pubStatus": ""
            }
        ]
    },
    {
        "interactionId": 8669,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 687,
        "ligandName": "amylin",
        "ligandContext": "",
        "endogenous": true,
        "type": "Agonist",
        "action": "Full agonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "9.0 - 9.7",
        "affinityParameter": "pEC50",
        "originalAffinity": "1x10<sup>-9</sup> - 1.94x10<sup>-10</sup>",
        "originalAffinityType": "EC50",
        "originalAffinityRelation": "=",
        "assayDescription": "Measuring ligand-induced cAMP production in COS and HEK293 cells.",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
            {
                "referenceId": 24560,
                "pmid": 24169554,
                "type": "Journal",
                "title": "Endocrinology",
                "year": 2014,
                "volume": "155",
                "issue": "1",
                "pages": "21-6",
                "articleTitle": "Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors.",
                "authors": "Gingell JJ, Burns ER, Hay DL",
                "pubStatus": ""
            }
        ]
    },
    {
        "interactionId": 84113,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 3766,
        "ligandName": "[<sup>125</sup>I]<i>&alpha;</i>CGRP",
        "ligandContext": "",
        "endogenous": false,
        "type": "Agonist",
        "action": "Agonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "9.0 - 10.0",
        "affinityParameter": "pKd",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
        ]
    },
    {
        "interactionId": 2119,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 690,
        "ligandName": "calcitonin-(8-32) (salmon)",
        "ligandContext": "",
        "endogenous": false,
        "type": "Antagonist",
        "action": "Antagonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "7.8",
        "affinityParameter": "pKB",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            }
        ]
    },
    {
        "interactionId": 2109,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 682,
        "ligandName": "&beta;-CGRP",
        "endogenous": true,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "9.2",
        "affinityParameter": "pEC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            }
        ]
    },
    {
        "interactionId": 2110,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 683,
        "ligandName": "adrenomedullin",
        "endogenous": true,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "6.5 - 8.4",
        "affinityParameter": "pEC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            },
            {
                "referenceId": 1688,
                "pmid": 12565884,
                "type": "Journal",
                "title": "Biochem Biophys Res Commun",
                "year": 2003,
                "volume": "301",
                "issue": "2",
                "pages": "460-4",
                "articleTitle": "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.",
                "authors": "Kuwasako K, Kitamura K, Nagoshi Y, Eto T"
            }
        ]
    },
    {
        "interactionId": 2114,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 692,
        "ligandName": "Tyr<sup>0</sup>&alpha;-CGRP (human)",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "7.6 - 9.5",
        "affinityParameter": "pEC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            },
            {
                "referenceId": 1687,
                "pmid": 14722252,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2004,
                "volume": "65",
                "issue": "1",
                "pages": "207-13",
                "articleTitle": "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.",
                "authors": "Kuwasako K, Cao YN, Nagoshi Y, Tsuruda T, Kitamura K, Eto T"
            }
        ]
    },
    {
        "interactionId": 2115,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 693,
        "ligandName": "[Cys(Et)2,7]&alpha;-CGRP (human)",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "7.8 - 8.4",
        "affinityParameter": "pEC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            },
            {
                "referenceId": 1687,
                "pmid": 14722252,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2004,
                "volume": "65",
                "issue": "1",
                "pages": "207-13",
                "articleTitle": "Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.",
                "authors": "Kuwasako K, Cao YN, Nagoshi Y, Tsuruda T, Kitamura K, Eto T"
            }
        ]
    },
    {
        "interactionId": 2112,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "ligandId": 685,
        "ligandName": "calcitonin",
        "endogenous": true,
        "type": "Agonist",
        "action": "Full agonist",
        "concentrationRange": "",
        "affinity": "8.9 - 11.3",
        "affinityParameter": "pEC50",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": false,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            },
            {
                "referenceId": 1685,
                "pmid": 11023820,
                "type": "Journal",
                "title": "Biochem J",
                "year": 2000,
                "volume": "351",
                "pages": "347-351",
                "articleTitle": "Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.",
                "authors": "Leuthauser K, Gujer R, Aldecoa A, McKinney RA, Muff R, Fischer JA, Born W"
            },
            {
                "referenceId": 1690,
                "pmid": 11033437,
                "type": "Journal",
                "title": "J Pharmacol Toxicol Methods",
                "year": 1999,
                "volume": "42",
                "issue": "4",
                "pages": "217-24",
                "articleTitle": "Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor.",
                "authors": "Armour SL, Foord S, Kenakin T, Chen WJ"
            }
        ]
    },
    {
        "interactionId": 81031,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 7482,
        "ligandName": "pramlintide",
        "ligandContext": "",
        "endogenous": false,
        "type": "Agonist",
        "action": "Agonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "9.4 - 9.4",
        "affinityParameter": "pEC50",
        "originalAffinity": "4.36x10<sup>-10</sup> - 3.55x10<sup>-10</sup>",
        "originalAffinityType": "EC50",
        "originalAffinityRelation": "=",
        "assayDescription": "Measuring ligand-induced cAMP production in COS and HEK293 cells.",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
            {
                "referenceId": 24560,
                "pmid": 24169554,
                "type": "Journal",
                "title": "Endocrinology",
                "year": 2014,
                "volume": "155",
                "issue": "1",
                "pages": "21-6",
                "articleTitle": "Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors.",
                "authors": "Gingell JJ, Burns ER, Hay DL",
                "pubStatus": ""
            }
        ]
    },
    {
        "interactionId": 84112,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 702,
        "ligandName": "olcegepant",
        "ligandContext": "",
        "endogenous": false,
        "type": "Antagonist",
        "action": "Antagonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "7.5",
        "affinityParameter": "pKB",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
            {
                "referenceId": 1770,
                "pmid": 16959943,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2006,
                "volume": "70",
                "pages": "1984-1991",
                "articleTitle": "Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors--the role of receptor activity modifying protein 1.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Sexton PM"
            }
        ]
    },
    {
        "interactionId": 89499,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 6973,
        "ligandName": "calcitonin (salmon)",
        "ligandContext": "",
        "endogenous": false,
        "type": "Agonist",
        "action": "Full agonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "",
        "affinityParameter": "",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
        ]
    },
    {
        "interactionId": 2117,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 689,
        "ligandName": "AC187",
        "ligandContext": "",
        "endogenous": false,
        "type": "Antagonist",
        "action": "Antagonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "8.0",
        "affinityParameter": "pKB",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
            {
                "referenceId": 1665,
                "pmid": 15692146,
                "type": "Journal",
                "title": "Mol Pharmacol",
                "year": 2005,
                "volume": "67",
                "issue": "5",
                "pages": "1655-65",
                "articleTitle": "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.",
                "authors": "Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM"
            }
        ]
    },
    {
        "interactionId": 89500,
        "targetId": 44,
        "targetName": "AMY<sub>1</sub> receptor",
        "ligandAsTargetId": 0,
        "targetSpecies": "Human",
        "primaryTarget": false,
        "targetBindingSite": "",
        "ligandId": 10704,
        "ligandName": "rimegepant",
        "ligandContext": "",
        "endogenous": false,
        "type": "Antagonist",
        "action": "Antagonist",
        "actionComment": "",
        "selectivity": "Not Determined",
        "concentrationRange": "",
        "affinity": "8.1",
        "affinityParameter": "pKB",
        "originalAffinity": "",
        "originalAffinityType": "",
        "originalAffinityRelation": "=",
        "assayDescription": "",
        "assayConditions": "",
        "useDependent": false,
        "voltageDependent": false,
        "voltage": "",
        "physiologicalVoltage": false,
        "conciseView": true,
        "refs": [
            {
                "referenceId": 45080,
                "pmid": 32973499,
                "type": "Journal",
                "title": "Front Pharmacol",
                "year": 2020,
                "volume": "11",
                "issue": "",
                "pages": "1240",
                "articleTitle": "Antagonism of CGRP Signaling by Rimegepant at Two Receptors.",
                "authors": "Pan KS, Siow A, Hay DL, Walker CS",
                "pubStatus": "",
                "doi": ""
            }
        ]
    }
]