Chronic myelogenous leukemia

Disease ID:1224
Name:Chronic myelogenous leukemia
Associated with:0 target
1 immuno-relevant ligand
Synonyms
chronic granulocytic leukemia | CML | myeloid leukemia, chronic
Description
A myeloid leukemia characterized by over production of white blood cells.
Database Links
Disease Ontology: DOID:8552
OMIM: 608232

Targets

No target related data available for Chronic myelogenous leukemia

Ligands

Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
imatinib
Immuno Disease Comments: Approved drug for CML.
Clinical Use: Used in the treatment of multiple cancers including chronic myelogenous leukemia and gastrointestinal stromal tumours (GIST). Adjuvant imatinib is recommended for KIT-mutated GISTs. The clinically administered form is the Imatinib mesilate (mesylate) salt (PubChem CID 123596).
Generic imatinib mesylate tablets were approved by the US FDA in December 2015, as therapeutic equivalents of Novartis' original Gleevec. | View clinical data
Bioactivity Comments: Off-targets include PDGFRA, PDGFRB and KIT. | View biological activity