Database content
Current database content for version 2024.1 released 26 March 2024.
| Target Class | Number of human targets‡ |
|---|---|
| 7TM receptors | 399 |
| G protein-coupled receptors including orphans | 394 |
| Orphan G protein-coupled receptors* | 122 |
| Other 7TM proteins | 5 |
| Nuclear hormone receptors | 48 |
| Catalytic receptors | 253 |
| Ligand-gated ion channels | 81 |
| Voltage-gated ion channels | 144 |
| Other ion channels | 53 |
| Enzymes | 1301 |
| Transporters | 555 |
| Other protein targets | 233 |
| Total number of targets | 3067 |
| Chemical Class | Number of ligands |
|---|---|
| Synthetic organics | 8916 |
| Metabolites | 514 |
| Endogenous peptides | 817 |
| Other peptides including synthetic peptides | 1512 |
| Natural Products | 416 |
| Antibodies | 376 |
| Inorganics | 39 |
| Approved drugs | 1981 |
| Withdrawn drugs | 109 |
| Drugs with INNs | 3446 |
| Labelled ligands | 649 |
| Total number of ligands | 12590 |
| Category | Count in database |
|---|---|
| Number of curated binding constants | 20789 |
| Number of binding constants from large-scale screens | 31207 |
| Number of references | 45361 |
| Human targets with curated interactions | 1984 |
| Human targets with quantitative interactions | 1732 |
| Human targets with quantitative interactions with CIDs | 1560 |
| Human targets of approved drugs | 743 |
| Human primary targets of approved drugs | 350 |
| Approved drugs with quantitative interactions | 1128 |
| Ligands with target interactions | 10405 |
| Ligands with quantitative interactions | 9204 |
| Ligands with CID and quantitative interactions | 7756 |
| Ligands with clinical use summary | 3704 |
| Approved drugs with clincial use summary | 1971 |
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‡ Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.
