Cardiovascular disease

Disease ID:189
Name:Cardiovascular disease
Associated with:2 targets
0 immuno-relevant targets
0 immuno-relevant ligands

Targets

FPR2/ALX
Mutations:  FPR2/ALX is associated with 1 mutation. Click here for details
regulator of G-protein signaling 6
Comments:  Doxorubicin and alcohol mediated cardiomyopathy.
References:  2-3

Ligands

No ligand related data available for Cardiovascular disease

References

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1. Simiele F, Recchiuti A, Mattoscio D, De Luca A, Cianci E, Franchi S, Gatta V, Parolari A, Werba JP, Camera M et al.. (2012) Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity. FASEB J., 26 (3): 1323-33. [PMID:22131270]

2. Stewart A, Maity B, Anderegg SP, Allamargot C, Yang J, Fisher RA. (2015) Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol. Proc. Natl. Acad. Sci. U.S.A., 112 (7): E786-95. [PMID:25646431]

3. Yang J, Maity B, Huang J, Gao Z, Stewart A, Weiss RM, Anderson ME, Fisher RA. (2013) G-protein inactivator RGS6 mediates myocardial cell apoptosis and cardiomyopathy caused by doxorubicin. Cancer Res., 73 (6): 1662-7. [PMID:23338613]