Lymphoma, non-hodgkin, familial

Disease ID:578
Name:Lymphoma, non-hodgkin, familial
Associated with:4 targets
0 immuno-relevant targets
2 immuno-relevant ligands
Synonyms
Non-Hodgkin lymphoma
Description
A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and lethargy.
Database Links
Disease Ontology: DOID:0060060
OMIM: 605027

Targets

regulator of G-protein signaling 5
Comments:  RGS5 transcripts are greatly increased in eight subtypes of lymphoma.
References:  3

Ligands

Ligand Approved Immuno References Clinical comments
IL-21 1
Immuno Disease Comments: HL cancer cells produce IL-21 which could explain the clustering of other immune cells around HL cells observed in vitro.
lymphotoxin-α
Immuno Disease Comments: Approved therapy for this indication.

References

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1. Lamprecht B, Kreher S, Anagnostopoulos I, Jöhrens K, Monteleone G, Jundt F, Stein H, Janz M, Dörken B, Mathas S. (2008) Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood, 112 (8): 3339-47. [PMID:18684866]

2. Lee JW, Yoo NJ, Soung YH, Kim HS, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ et al.. (2003) BRAF mutations in non-Hodgkin's lymphoma. Br. J. Cancer, 89 (10): 1958-60. [PMID:14612909]

3. Sethakorn N, Dulin NO. (2013) RGS expression in cancer: oncomining the cancer microarray data. J. Recept. Signal Transduct. Res., 33 (3): 166-71. [PMID:23464602]