Lymphoma, non-hodgkin, familial

Disease ID:578
Name:Lymphoma, non-hodgkin, familial
Associated with:4 targets
2 immuno-relevant ligands
Synonyms
Non-Hodgkin lymphoma
Description
A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and lethargy.
Database Links
Disease Ontology: DOID:0060060
OMIM: 605027

Targets

Caspase 10
TLR9
B-Raf proto-oncogene, serine/threonine kinase
References:  3
regulator of G-protein signaling 5
Comments:  RGS5 transcripts are greatly increased in eight subtypes of lymphoma.
References:  4

Ligands

Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
IL-21 2
Immuno Disease Comments: HL cancer cells produce IL-21 which could explain the clustering of other immune cells around HL cells observed in vitro.
Bioactivity Comments: IL-21 has been shown to eliminate glioblastoma multiforme cells via activation of the cytolytic reactivity of Vγ9Vδ2 T cells in vitro and in an in vivo model [1]. These findings suggest that IL-21-sensitized allogeneic human Vγ9Vδ2 T cells might offer a novel immunotherapeutic approach for the treatment of glioblastoma multiforme. | View biological activity
lymphotoxin-α
Immuno Disease Comments: Approved therapy for this indication.

References

Show »

1. Joalland N, Chauvin C, Oliver L, Vallette FM, Pecqueur C, Jarry U, Scotet E. (2018) IL-21 Increases the Reactivity of Allogeneic Human Vγ9Vδ2 T Cells Against Primary Glioblastoma Tumors. J. Immunother., 41 (5): 224-231. [PMID:29683891]

2. Lamprecht B, Kreher S, Anagnostopoulos I, Jöhrens K, Monteleone G, Jundt F, Stein H, Janz M, Dörken B, Mathas S. (2008) Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood, 112 (8): 3339-47. [PMID:18684866]

3. Lee JW, Yoo NJ, Soung YH, Kim HS, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ et al.. (2003) BRAF mutations in non-Hodgkin's lymphoma. Br. J. Cancer, 89 (10): 1958-60. [PMID:14612909]

4. Sethakorn N, Dulin NO. (2013) RGS expression in cancer: oncomining the cancer microarray data. J. Recept. Signal Transduct. Res., 33 (3): 166-71. [PMID:23464602]