Medulloblastoma

Disease ID:599
Name:Medulloblastoma
Associated with:2 targets
0 immuno-relevant targets
0 immuno-relevant ligands
Database Links
Disease Ontology: DOID:3858
OMIM: 155255

Targets

FZD8
References:  2
Kv10.2
Role:  EAG2 upregulation in a subset of medulloblastoma
Comments:  EAG2 promotes medulloblastoma cell proliferation and migration. Knockdown of EAG2 or inhibition of EAG2 channels with channel blockers reduce medulloblastoma growth and metastasis in mouse models.
References:  1

Ligands

No ligand related data available for Medulloblastoma

References

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1. Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester, CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nature Neurosci., [in press].

2. Salsano E, Paterra R, Figus M, Menghi F, Maderna E, Pollo B, Solero CL, Massimi L, Finocchiaro G. (2012) Expression profile of frizzled receptors in human medulloblastomas. J. Neurooncol., 106 (2): 271-80. [PMID:21850537]