Nicotine dependence, susceptibility to

Disease ID:688
Name:Nicotine dependence, susceptibility to
Associated with:2 targets
Database Links
Disease Ontology: DOID:0050742
OMIM: 612052

Targets

nicotinic acetylcholine receptor α3 subunit
Role:  Single nucleotide polymorphisms in this gene are associated with susceptibility to nicotine dependence and lung cancer.
References:  3,5-6
Mutations:  nicotinic acetylcholine receptor α3 subunit is associated with 1 mutation. Click here for details
nicotinic acetylcholine receptor α5 subunit
Role:  Single nucleotide polymorphisms in this gene are associated with susceptibility to nicotine dependence and lung cancer.
References:  2-5
Mutations:  nicotinic acetylcholine receptor α5 subunit is associated with 1 mutation. Click here for details

Ligands

No ligand related data available for Nicotine dependence, susceptibility to

References

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1. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J et al.. (2008) Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat. Genet., 40 (5): 616-22. [PMID:18385676]

2. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P et al.. (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature, 452 (7187): 633-7. [PMID:18385738]

3. Improgo MR, Scofield MD, Tapper AR, Gardner PD. (2010) The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog. Neurobiol., 92 (2): 212-26. [PMID:20685379]

4. Kuryatov A, Berrettini W, Lindstrom J. (2011) Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function. Mol. Pharmacol., 79 (1): 119-25. [PMID:20881005]

5. Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O et al.. (2007) Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum. Mol. Genet., 16 (1): 36-49. [PMID:17135278]

6. Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP, Manolescu A, Thorleifsson G, Stefansson H, Ingason A et al.. (2008) A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature, 452 (7187): 638-42. [PMID:18385739]