Osteoporosis

Disease ID:723
Name:Osteoporosis
Associated with:3 targets
Database Links
Disease Ontology: DOID:11476
OMIM: 166710

Targets

RXFP2
Role:  Men with the T222P mutation of RXFP2 show a markedly increased susceptibility to osteoporosis a condition that is also displayed by RXFP2 knockout mice
References:  1
Estrogen-related receptor-α
Comments:  There is a statistical association between ERR alpha promoter polymorphism and lumbar spine Bone Mineral Density (BMD).
References:  2
regulator of G-protein signaling 10
References:  3

Ligands

No ligand related data available for Osteoporosis

References

Show »

1. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. (2009) New roles for INSL3 in adults. Ann. N. Y. Acad. Sci., 1160: 215-8. [PMID:19416191]

2. Laflamme N, Giroux S, Loredo-Osti JC, Elfassihi L, Dodin S, Blanchet C, Morgan K, Giguère V, Rousseau F. (2005) A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women. J. Bone Miner. Res., 20 (6): 938-44. [PMID:15883633]

3. Yang S, Li YP. (2007) RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation. Genes Dev., 21 (14): 1803-16. [PMID:17626792]