Calcium-sensing receptor C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [11]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and polycationic peptides, L-amino acids (particularly L-Trp and L-Phe), glutathione and various peptide analogues, ionic strength and extracellular pH (reviewed in [21]). While divalent/trivalent cations, polyamines and polycations are CaS receptor agonists [3,31], L-amino acids, glutamyl peptides, ionic strength and pH are allosteric modulators of agonist function [8,11,16,29-30]. Indeed, L-amino acids have been identified as "co-agonists", with both concomitant calcium and L-amino acid binding required for full receptor activation [13,38]. The sensitivity of the CaS receptor to primary agonists is increased by elevated extracellular pH [4] or decreased extracellular ionic strength [30]. This receptor bears no sequence or structural relation to the plant calcium receptor, also called CaS.

Receptors

CaS receptor C Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Hans Bräuner-Osborne, Katie Leach, Wenhan Chang, Arthur Conigrave, Fadil Hannan, Daniela Riccardi, Polina Yarova, Daniel Bikle, Edward M. Brown, Dolores Shoback, Donald T. Ward. Calcium-sensing receptor. Accessed on 26/05/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=12.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.