Calcium-sensing receptor C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [11]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and polycationic peptides, L-amino acids (particularly L-Trp and L-Phe), glutathione and various peptide analogues, ionic strength and extracellular pH (reviewed in [21]). While divalent/trivalent cations, polyamines and polycations are CaS receptor agonists [3,31], L-amino acids, glutamyl peptides, ionic strength and pH are allosteric modulators of agonist function [8,11,16,29-30]. Indeed, L-amino acids have been identified as "co-agonists", with both concomitant calcium and L-amino acid binding required for full receptor activation [13,38]. The sensitivity of the CaS receptor to primary agonists is increased by elevated extracellular pH [4] or decreased extracellular ionic strength [30]. This receptor bears no sequence or structural relation to the plant calcium receptor, also called CaS.

Receptors

CaS receptor C Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Hans Bräuner-Osborne, Katie Leach, Wenhan Chang, Arthur Conigrave, Fadil Hannan, Daniela Riccardi, Polina Yarova, Daniel Bikle, Edward M. Brown, Dolores Shoback, Donald T. Ward. Calcium-sensing receptor. Accessed on 30/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=12.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.