Calcium-sensing receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [4]) responds to extracellular calcium and magnesium in the millimolar range and to gadolinium and some polycations in the micromolar range [1]. The sensitivity of CaS to primary agonists can be increased by aromatic L-amino acids [3] and also by elevated extracellular pH [13] or decreased extracellular ionic strength [14]. This receptor bears no sequence or structural relation to the plant calcium receptor, also called CaS.


CaS receptor Show summary » More detailed page

GPRC6 receptor Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Edward M. Brown, Hans Bräuner-Osborne, Daniel Bikle, Arthur Conigrave, Dolores Shoback, Donald T. Ward. Calcium-sensing receptors. Accessed on 28/02/2017. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.