Calcium-sensing receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [4]) responds to extracellular calcium and magnesium in the millimolar range and to gadolinium and some polycations in the micromolar range [1]. The sensitivity of CaS to primary agonists can be increased by aromatic L-amino acids [3] and also by elevated extracellular pH [13] or decreased extracellular ionic strength [14]. This receptor bears no sequence or structural relation to the plant calcium receptor, also called CaS.


CaS receptor Show summary » More detailed page

GPRC6 receptor Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Edward M. Brown, Hans Bräuner-Osborne, Daniel Bikle, Arthur Conigrave, Dolores Shoback, Donald T. Ward. Calcium-sensing receptors. Accessed on 29/11/2015. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.