Resolvin receptors (provisional nomenclature) are activated by the lipid-derived, anti-inflammatory ligand resolvin E1 (RvE1), which is the result of sequential metabolism of EPA by aspirin-modified cyclooxygenase and lipoxygenase [1-2]. In addition, 2 GPCRs for resolvin D1 (RvD1) have been identified, FPR2/ALX, the lipoxin A₄ receptor, and GPR32, an orphan receptor [3].

1. Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A. and Serhan, C. N. (2005) Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med, 201: 713-722. [PMID:15753205]

2. Arita, M; Ohira, T; Sun, YP; Elangovan, S; Chiang, N; Serhan, CN. (2007) Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J. Immunol., 178 (6): 3912-7. [PMID:17339491]

3. Krishnamoorthy, S; Recchiuti, A; Chiang, N; Yacoubian, S; Lee, CH; Yang, R; Petasis, NA; Serhan, CN. (2010) Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc. Natl. Acad. Sci. U.S.A., 107 (4): 1660-5. [PMID:20080636]

4. Luangsay, S; Wittamer, V; Bondue, B; De Henau, O; Rouger, L; Brait, M; Franssen, JD; de Nadai, P; Huaux, F; Parmentier, M. (2009) Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model. J. Immunol., 183 (10): 6489-99. [PMID:19841182]

5. Meder, W., Wendland, M., Busmann, A., Kutzleb, C., Spodsberg, N., John, H., Richter, R., Schleuder, D., Meyer, M. and Forssmann, W. G. (2003) Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23. FEBS Lett, 555: 495-499. [PMID:14675762]

6. Zabel, BA; Silverio, AM; Butcher, EC. (2005) Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J. Immunol., 174 (1): 244-51. [PMID:15611246]