SLC36 family of proton-coupled amino acid transporters

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC36 family of proton-coupled amino acid transporters (or PAT) is highly expressed in the intestine and kidney, having roles in the disposition of amino acids [17]. PAT1 is found on the gut epithelia luminal surface accumulating dietary amino acids, and additionally in lysosomal membranes where it likely functions as an efflux mechanism for amino acids produced during intralysosomal proteolysis [2,16]. PAT2 is found at the apical membrane of the kidney proximal tubule [5]. PAT1 and PAT2 are predicted to have 11 TM domains with intracellular N-termini [3,16].

Transporters

PAT1 (Proton-coupled Amino acid Transporter 1 / SLC36A1) Show summary »

PAT2 (Proton-coupled Amino acid Transporter 2 / SLC36A2) Show summary »

PAT3 (Proton-coupled Amino acid Transporter 3 / SLC36A3) Show summary »

PAT4 (Proton-coupled Amino acid Transporter 4 / SLC36A4) Show summary »

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How to cite this family page

Database page citation:

SLC36 family of proton-coupled amino acid transporters. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=223.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.