Adenosine turnover C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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A multifunctional, ubiquitous molecule, adenosine acts at cell-surface G protein-coupled receptors, as well as numerous enzymes, including protein kinases and adenylyl cyclase. Extracellular adenosine is thought to be produced either by export or by metabolism, predominantly through ecto-5’-nucleotidase activity (also producing inorganic phosphate). It is inactivated either by extracellular metabolism via adenosine deaminase (also producing ammonia) or, following uptake by nucleoside transporters, via adenosine deaminase or adenosine kinase (requiring ATP as co-substrate). Intracellular adenosine may be produced by cytosolic 5’-nucleotidases or through S-adenosylhomocysteine hydrolase (also producing L-homocysteine).

Enzymes

ADA (Adenosine deaminase) C Show summary » More detailed page

ADK (Adenosine kinase) C Show summary »

NT5E (Ecto-5'-Nucleotidase / CD73) C Show summary » More detailed page

SAHH (S-Adenosylhomocysteine hydrolase) C Show summary »

5'-nucleotidase IA Show summary »

5'-nucleotidase IB Show summary »

5'-nucleotidase II Show summary »

5'-nucleotidase III Show summary »

5'(3')-nucleotidase Show summary »

Mitochondrial 5'-nucleotidase Show summary »

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Detlev Boison. Adenosine turnover. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=248.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.