Melanin-concentrating hormone receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Melanin-concentrating hormone (MCH) receptors (provisional nomenclature as recommended by NC-IUPHAR [5]) are activated by an endogenous nonadecameric cyclic peptide identical in humans and rats (DFDMLRCMLGRVYRPCWQV) generated from a precursor (PMCH, P20382), which also produces neuropeptide EI (PMCH, P20382) and neuropeptide GE (PMCH, P20382).


MCH1 receptor Show summary » More detailed page

MCH2 receptor Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Jean A. Boutin, Valérie Audinot, Jean-Louis Nahon, Bernard Lakaye, Yumito Saito. Melanin-concentrating hormone receptors. Accessed on 29/11/2015. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.