More information on this family may be found on the IUPHAR-DB family and introduction pages.
The neuropeptide S receptor (NPS, provisional nomenclature, [2]) responds to the 20 amino-acid peptide neuropeptide S (NPS) derived from a precursor (ENSG00000214285).
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Receptors 
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Dal Ben, D; Antonini, I; Buccioni, M; Lambertucci, C; Marucci, G; Thomas, A; Volpini, R; Cristalli, G. (2011) Neuropeptide S receptor: recent updates on nonpeptide antagonist discovery. ChemMedChem, 6 (7): 1163-71. [PMID:21452188]
Dal Ben, D; Antonini, I; Buccioni, M; Lambertucci, C; Marucci, G; Vittori, S; Volpini, R; Cristalli, G. (2010) Molecular modeling studies on the human neuropeptide S receptor and its antagonists. ChemMedChem, 5 (3): 371-83. [PMID:20087922]
Foord, S. M., Bonner, T. I., Neubig, R. R., Rosser, E. M., Pin, J. P., Davenport, A. P., Spedding, M. and Harmar, A. J. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev, 57: 279-288. [PMID:15914470]
Guerrini, R; Salvadori, S; Rizzi, A; Regoli, D; Calo', G. (2010) Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor. Med Res Rev, 30 (5): 751-77. [PMID:19824051]
Pape, HC; Jüngling, K; Seidenbecher, T; Lesting, J; Reinscheid, RK. (2010) Neuropeptide S: a transmitter system in the brain regulating fear and anxiety. Neuropharmacology, 58 (1): 29-34. [PMID:19523478]
Reinscheid, RK. (2008) Neuropeptide S: anatomy, pharmacology, genetics and physiological functions. Results Probl Cell Differ, 46: 145-58. [PMID:18204825]
1. D'Amato, M; Bruce, S; Bresso, F; Zucchelli, M; Ezer, S; Pulkkinen, V; Lindgren, C; Astegiano, M; Rizzetto, M; Gionchetti, P; et al.. (2007) Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease. Gastroenterology, 133 (3): 808-17. [PMID:17854592]
2. Foord, S. M., Bonner, T. I., Neubig, R. R., Rosser, E. M., Pin, J. P., Davenport, A. P., Spedding, M. and Harmar, A. J. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev, 57: 279-288. [PMID:15914470]
3. Gupte, J., Cutler, G., Chen, J. L. and Tian, H. (2004) Elucidation of signaling properties of vasopressin receptor-related receptor 1 by using the chimeric receptor approach. Proc. Natl. Acad. Sci. U.S.A., 101: 1508-1513. [PMID:14757815]
4. Vendelin, J; Pulkkinen, V; Rehn, M; Pirskanen, A; Räisänen-Sokolowski, A; Laitinen, A; Laitinen, LA; Kere, J; Laitinen, T. (2005) Characterization of GPRA, a novel G protein-coupled receptor related to asthma. Am. J. Respir. Cell Mol. Biol., 33 (3): 262-70. [PMID:15947423]
5. Xu, Y. L., Reinscheid, R. K., Huitron-Resendiz, S., Clark, S. D., Wang, Z., Lin, S. H., Brucher, F. A., Zeng, J., Ly, N. K., Henriksen, S. J., De Lecea, L. and Civelli, O. (2004) Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron, 43: 487-497. [PMID:15312648]
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Polymorphisms in the NPS receptor have been suggested to be associated with asthma [4] and irritable bowel syndrome [1].