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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The neuropeptide BW receptor 1 (NPBW1, provisional nomenclature ) is activated by two 23-amino-acid peptides, neuropeptide W (neuropeptide W-23 (NPW, Q8N729)) and neuropeptide B (neuropeptide B-23 (NPB, Q8NG41)) [3,7]. C-terminally extended forms of the peptides (neuropeptide W-30 (NPW, Q8N729) and neuropeptide B-29 (NPB, Q8NG41)) also activate NPBW1 . Unique to both forms of neuropeptide B is the N-terminal bromination of the first tryptophan residue, and it is from this post-translational modification that the nomenclature NPB is derived. These peptides were first identified from bovine hypothalamus and therefore are classed as neuropeptides. Endogenous variants of the peptides without the N-terminal bromination, des-Br-neuropeptide B-23 (NPB, Q8NG41) and des-Br-neuropeptide B-29 (NPB, Q8NG41), were not found to be major components of bovine hypothalamic tissue extracts. The NPBW2 receptor is activated by the short and C-terminal extended forms of neuropeptide W and neuropeptide B .
* Key recommended reading is highlighted with an asterisk
* Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S et al.. (2010) Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state. Endocrinology, 151 (5): 2200-10. [PMID:20189998]
* Hondo M, Ishii M, Sakurai T. (2008) The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results Probl Cell Differ, 46: 239-56. [PMID:18204824]
Lee DK, George SR, O'Dowd BF. (2003) Continued discovery of ligands for G protein-coupled receptors. Life Sci., 74 (2-3): 293-7. [PMID:14607257]
Patra MC, Maharana J, Dehury B, De S. (2014) Computational insights into the binding mechanism of antagonists with neuropeptide B/W receptor 1. Mol Biosyst, 10 (8): 2236-46. [PMID:24938207]
* Sakurai T. (2013) NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion. Front Endocrinol (Lausanne), 4: 23. [PMID:23515889]
* Singh G, Davenport AP. (2006) Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. Br. J. Pharmacol., 148 (8): 1033-41. [PMID:16847439]
1. Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M. (2003) Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. J Biol Chem., 278: 776-783. [PMID:12401809]
2. Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev, 57: 279-288. [PMID:15914470]
3. Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M. (2002) Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. J Biol Chem., 277: 34010-34016. [PMID:12118011]
4. Kanesaka M, Matsuda M, Hirano A, Tanaka K, Kanatani A, Tokita S. (2007) Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B. J. Pept. Sci., 13 (6): 379-85. [PMID:17486669]
5. Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG. (2005) G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. J Clin Endocrinol Metab., 90: 3466-3471. [PMID:15797961]
6. Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y et al.. (2011) Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory. PLoS ONE, 6 (2): e16972. [PMID:21390312]
7. Shimomura Y, Harada M, Goto M, Sugo T, Matsumoto Y, Abe M, Watanabe T, Asami T, Kitada C, Mori M, Onda H, Fujino M. (2002) Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J Biol Chem., 277: 35826-35832. [PMID:12130646]
8. Singh G, Maguire JJ, Kuc RE, Fidock M, Davenport AP. (2004) Identification and cellular localisation of NPW1 (GPR7) receptors for the novel neuropeptide W-23 by [125I]-NPW radioligand binding and immunocytochemistry. Brain Res., 1017: 222-226. [PMID:15261118]
Database page citation:
Anthony P. Davenport, Gurminder Singh. Neuropeptide W/neuropeptide B receptors. Accessed on 04/05/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=45.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.