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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The neuropeptide BW receptor 1 (NPBW1, provisional nomenclature ) is activated by two 23-amino-acid peptides, neuropeptide W (neuropeptide W-23 (NPW, Q8N729)) and neuropeptide B (neuropeptide B-23 (NPB, Q8NG41)) [3,7]. C-terminally extended forms of the peptides (neuropeptide W-30 (NPW, Q8N729) and neuropeptide B-29 (NPB, Q8NG41)) also activate NPBW1 . Unique to both forms of neuropeptide B is the N-terminal bromination of the first tryptophan residue, and it is from this post-translational modification that the nomenclature NPB is derived. These peptides were first identified from bovine hypothalamus and therefore are classed as neuropeptides. Endogenous variants of the peptides without the N-terminal bromination, des-Br-neuropeptide B-23 (NPB, Q8NG41) and des-Br-neuropeptide B-29 (NPB, Q8NG41), were not found to be major components of bovine hypothalamic tissue extracts. The NPBW2 receptor is activated by the short and C-terminal extended forms of neuropeptide W and neuropeptide B .
* Key recommended reading is highlighted with an asterisk
* Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S et al.. (2010) Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state. Endocrinology, 151 (5): 2200-10. [PMID:20189998]
* Hondo M, Ishii M, Sakurai T. (2008) The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results Probl Cell Differ, 46: 239-56. [PMID:18204824]
Lee DK, George SR, O'Dowd BF. (2003) Continued discovery of ligands for G protein-coupled receptors. Life Sci., 74 (2-3): 293-7. [PMID:14607257]
Patra MC, Maharana J, Dehury B, De S. (2014) Computational insights into the binding mechanism of antagonists with neuropeptide B/W receptor 1. Mol Biosyst, 10 (8): 2236-46. [PMID:24938207]
* Sakurai T. (2013) NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion. Front Endocrinol (Lausanne), 4: 23. [PMID:23515889]
* Singh G, Davenport AP. (2006) Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. Br. J. Pharmacol., 148 (8): 1033-41. [PMID:16847439]
1. Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M. (2003) Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. J Biol Chem., 278: 776-783. [PMID:12401809]
2. Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev, 57: 279-288. [PMID:15914470]
3. Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M. (2002) Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. J Biol Chem., 277: 34010-34016. [PMID:12118011]
4. Kanesaka M, Matsuda M, Hirano A, Tanaka K, Kanatani A, Tokita S. (2007) Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B. J. Pept. Sci., 13 (6): 379-85. [PMID:17486669]
5. Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG. (2005) G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. J Clin Endocrinol Metab., 90: 3466-3471. [PMID:15797961]
6. Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y et al.. (2011) Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory. PLoS ONE, 6 (2): e16972. [PMID:21390312]
7. Shimomura Y, Harada M, Goto M, Sugo T, Matsumoto Y, Abe M, Watanabe T, Asami T, Kitada C, Mori M, Onda H, Fujino M. (2002) Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J Biol Chem., 277: 35826-35832. [PMID:12130646]
8. Singh G, Maguire JJ, Kuc RE, Fidock M, Davenport AP. (2004) Identification and cellular localisation of NPW1 (GPR7) receptors for the novel neuropeptide W-23 by [125I]-NPW radioligand binding and immunocytochemistry. Brain Res., 1017: 222-226. [PMID:15261118]
Database page citation:
Anthony P. Davenport, Gurminder Singh. Neuropeptide W/neuropeptide B receptors. Accessed on 26/11/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=45.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.