Neuropeptide W/neuropeptide B receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The neuropeptide BW receptor 1 (NPBW1) is activated by two 23-amino-acid peptides, neuropeptide W (NPW-23 (NPW, Q8N729)) and neuropeptide B (NPB-23 (NPB, Q8NG41)) [2,6]. C-terminally extended forms of the peptides (NPW-30 (NPW, Q8N729) and NPB-29 (NPB, Q8NG41)) also activate NPBW1 [1]. Unique to both forms of NPB is the N-terminal bromination of the first tryptophan residue. des-Br-NPB-23 (NPB, Q8NG41) and des-Br-NPB-29 (NPB, Q8NG41) were not found to be major components of bovine hypothalamic tissue extracts. The NPBW2 receptor is activated by the short and C-terminal extended forms of NPB and NPW [1].

Receptors

NPBW1 receptor Show summary » More detailed page

NPBW2 receptor Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Neuropeptide W/neuropeptide B receptors. Accessed on 20/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=45.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.