Somatostatin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (sst1-sst5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [6]). Activation of these receptors produces a wide range of physiological effects throughout the body including the inhibition of secretion of many hormones. The relationship of the cloned receptors to endogenously expressed receptors is not yet well established in some cases. Endogenous ligands for these receptors are somatostatin-14 (SRIF-14 (SST, P61278)) and somatostatin-28 (SRIF-28 (SST, P61278)). Cortistatin-14 has also been suggested to be an endogenous ligand for somatostatin receptors [3].


sst1 receptor Show summary » More detailed page

sst2 receptor Show summary » More detailed page

sst3 receptor Show summary » More detailed page

sst4 receptor Show summary » More detailed page

sst5 receptor Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Stefan Schulz, Corinne Bosquet, Justo Castano, Micheal Culler, Jacques Epelbaum, Leo Hofland, Daniel Hoyer, Jean-Claude Reubi, Herbert Schmid, Agnes Schonbrunn, Wasyl Feniuk, Anthony Harmar, Patrick P. A. Humphrey, Wolfgang Meyerhof, Anne-Marie O'Carroll, Yogesh C. Patel, Terry Reisine, Marcus Schindler, John E. Taylor, Annamaria Vezzani, Rebecca Hills. Somatostatin receptors. Accessed on 27/11/2015. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.