CatSper and Two-Pore channels

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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CatSper channels (CatSper1-4; nomenclature as agreed by NC-IUPHAR, [5]) are putative 6TM, voltage-gated, calcium permeant channels that are presumed to assemble as a tetramer of α-like subunits and mediate the current ICatSper. In mammals, CatSper subunits are structurally most closely related to individual domains of voltage-activated calcium channels (Cav) [17]. CatSper1 [17], CatSper2 [16] and CatSpers 3 and 4 [7,12,15], in common with a recently identified putative 2TM auxiliary CatSperβ protein [11] and two putative 1TM associated CatSperγ and CatSperδ proteins [4,19], are restricted to the testis and localised to the principle piece of sperm tail.

Channels and Subunits

CatSper1 Show summary » More detailed page

CatSper2 Show summary » More detailed page

CatSper3 Show summary » More detailed page

CatSper4 Show summary » More detailed page

TPC1 Show summary » More detailed page

TPC2 Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

CatSper and Two-Pore channels. Accessed on 04/07/2015. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels. Br J Pharmacol. 170: 1607–1651.