Sphingolipid Δ<sup>4</sup>-desaturase | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

Sphingolipid Δ⁴-desaturase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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DEGS1 and DEGS2 are 4TM proteins.

Enzymes

delta 4-desaturase, sphingolipid 1 C Show summary »« Hide summary

Target Id

2484

Nomenclature

delta 4-desaturase, sphingolipid 1

Previous and unofficial names

Genes

DEGS1 (Hs), Degs1 (Mm), Degs1 (Rn)

Ensembl ID

ENSG00000143753 (Hs), ENSMUSG00000038633 (Mm), ENSRNOG00000003223 (Rn)

UniProtKB AC

O15121 (Hs), O09005 (Mm), Q5XIF5 (Rn)

EC number

1.14.-.-

Cofactors

NAD

Inhibitors

RBM2-1B pIC₅₀ 4.7 [2]

Comment

Myristoylation of DEGS1 enhances its activity and targets it to the mitochondria [1].

delta 4-desaturase, sphingolipid 2 C Show summary »« Hide summary

Target Id

2485

Nomenclature

delta 4-desaturase, sphingolipid 2

Previous and unofficial names

DES2 | FADS8 | degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase | delta(4)-desaturase, sphingolipid 2 | delta(4)-desaturase

Genes

DEGS2 (Hs), Degs2 (Mm), Degs2 (Rn)

Ensembl ID

ENSG00000168350 (Hs), ENSMUSG00000021263 (Mm), ENSRNOG00000011716 (Rn)

UniProtKB AC

Q6QHC5 (Hs), Q8R2F2 (Mm), Q564G3 (Rn)

EC number

1.14.-.-

Cofactors

NAD

Comments

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References

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1. Beauchamp E, Tekpli X, Marteil G, Lagadic-Gossmann D, Legrand P, Rioux V. (2009) N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid. Biochimie, 91 (11-12): 1411-9. [PMID:19647031]

2. Camacho L, Simbari F, Garrido M, Abad JL, Casas J, Delgado A, Fabriàs G. (2012) 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg. Med. Chem., 20 (10): 3173-9. [PMID:22537678]

3. Fabrias G, Muñoz-Olaya J, Cingolani F, Signorelli P, Casas J, Gagliostro V, Ghidoni R. (2012) Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena. Prog. Lipid Res., 51 (2): 82-94. [PMID:22200621]

How to cite this family page

Database page citation:

Sphingolipid Δ⁴-desaturase. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=790.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.

Sphingolipid Δ4-desaturase C

Overview

Enzymes

Comments

References

How to cite this family page

Sphingolipid Δ⁴-desaturase C