1H. Liver X receptor-like receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

« Hide More detailed introduction

Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by NC-IUPHAR Committee on Nuclear Receptors, [6]) are members of a steroid analogue-activated nuclear receptor subfamily (ENSFM00500000269785), which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids.

Receptors

Farnesoid X receptor / NR1H4 Show summary » More detailed page

Farnesoid X receptor-β / NR1H5 Show summary » More detailed page

Liver X receptor-α / NR1H3 Show summary » More detailed page

Liver X receptor-β / NR1H2 Show summary » More detailed page

Comments

Show »

Further reading

Show »

References

Show »

How to cite this family page

Database page citation:

1H. Liver X receptor-like receptors. Accessed on 24/04/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=89.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Nuclear Hormone Receptors. Br J Pharmacol. 170: 1652–1675.