Regulators of G protein Signaling (RGS) proteins C


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Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits of heterotrimeric G proteins, enhancing GTP hydrolysis by stabilising the transition state [1-3], leading to a termination of GPCR signalling. Interactions through protein:protein interactions of many RGS proteins have been identified for targets other than heteromeric G proteins. Sequence analysis of the 20 RGS proteins suggests four families of RGS: RZ, R4, R7 and R12 families. Many of these proteins have been identified to have effects other than through targetting G proteins. Included here is RGS4 for which a number of pharmacological inhibitors have been described.


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Database page citation:

Benita Sjögren, Kirk M. Druey, Rory A. Fisher, John R. Hepler, Shelley B. Hooks, Kirill Martemyanov, David L. Roman, Thomas M. Wilkie, Zili Luo, Hoa Phan Thi Nhu, Vincent Shaw, Yalda Zolghadri, Bandana Chakravarti, Laurie Sutton, Keqiang Xie. Regulators of G protein Signaling (RGS) proteins. Accessed on 15/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.