Bombesin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Bombesin receptors (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors, [5]) are activated by the endogenous ligands gastrin-releasing peptide (GRP, P07492) (GRP), NMB (NMB, P08949) (NMB) and GRP-(18-27) (GRP, P07492) (previously named neuromedin C). bombesin is a tetradecapeptide, originally derived from amphibians. These receptors couple primarily to the Gq/11 family of G proteins (but see also [6]). Activation of BB1 and BB2 receptors causes a wide range of physiological actions, including the stimulation of tissue growth, smooth–muscle contraction, secretion and many central nervous system effects [12]. A physiological role for the BB3 receptor has yet to be fully defined although receptor knockout experiments suggest a role in energy balance and the control of body weight [5].

Receptors

BB1 receptor Show summary » More detailed page

BB3 receptor Show summary » More detailed page

BB2 receptor Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Bombesin receptors. Accessed on 20/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=9.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.