Bombesin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Bombesin receptors (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors, [7]) are activated by the endogenous ligands gastrin-releasing peptide (GRP, P07492) (GRP), neuromedin B (NMB, P08949) (NMB) and GRP-(18-27) (GRP, P07492) (previously named neuromedin C). Bombesin is a tetradecapeptide, originally derived from amphibians, and is an agonist at BB1 and BB2 receptors. These receptors couple primarily to the Gq/11 family of G proteins (but see also [7]). Each of these receptors is widely distributed in the CNS and peripheral tissues [4,7,25-26]. Activation of BB1 and BB2 receptors causes a wide range of physiological actions, including the stimulation of normal and neoplastic tissue growth, smooth-muscle contraction, appetite and feeding behavior, secretion and many central nervous system effects [7-9,13,21,25]. A physiological role for the BB3 receptor has yet to be fully defined although recently studies using receptor knockout mice and newly described agonists/antagonists suggest an important role in glucose and insulin regulation, metabolic homeostasis, feeding and other CNS behaviors and growth of normal/neoplastic tissues [4,14,24].

Receptors

BB1 receptor Show summary » More detailed page

BB2 receptor Show summary » More detailed page

BB3 receptor Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Robert T. Jensen, Jim Battey, Richard V. Benya, Terry W. Moody, Eliot Spindel. Bombesin receptors. Accessed on 02/09/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=9.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.