Bombesin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Bombesin receptors (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors, [7]) are activated by the endogenous ligands gastrin-releasing peptide (GRP, P07492) (GRP), neuromedin B (NMB, P08949) (NMB) and GRP-(18-27) (GRP, P07492) (previously named neuromedin C). Bombesin is a tetradecapeptide, originally derived from amphibians, and is an agonist at BB1 and BB2 receptors. These receptors couple primarily to the Gq/11 family of G proteins (but see also [7]). Each of these receptors is widely distributed in the CNS and peripheral tissues [4,7,25-26]. Activation of BB1 and BB2 receptors causes a wide range of physiological actions, including the stimulation of normal and neoplastic tissue growth, smooth-muscle contraction, appetite and feeding behavior, secretion and many central nervous system effects [7-9,13,21,25]. A physiological role for the BB3 receptor has yet to be fully defined although recently studies using receptor knockout mice and newly described agonists/antagonists suggest an important role in glucose and insulin regulation, metabolic homeostasis, feeding and other CNS behaviors and growth of normal/neoplastic tissues [4,14,24].

Receptors

BB1 receptor Show summary » More detailed page

BB2 receptor Show summary » More detailed page

BB3 receptor Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Robert T. Jensen, Jim Battey, Richard V. Benya, Terry W. Moody, Eliot Spindel. Bombesin receptors. Accessed on 14/02/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=9.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. Br J Pharmacol. 172: 5744-5869.