2A. Hepatocyte nuclear factor-4 receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The nomenclature of hepatocyte nuclear factor-4 receptors is agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1]. While linoleic acid has been identified as the endogenous ligand for HNF4α its function remains ambiguous [4]. HNF4γ has yet to be paired with an endogenous ligand.


Hepatocyte nuclear factor-4-α / NR2A1 Show summary » More detailed page

Hepatocyte nuclear factor-4-γ / NR2A2 Show summary » More detailed page

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Frances M. Sladek. 2A. Hepatocyte nuclear factor-4 receptors. Accessed on 22/10/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=91.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors. Br J Pharmacol. 172: 5956-5978.