2A. Hepatocyte nuclear factor-4 receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The nomenclature of hepatocyte nuclear factor-4 receptors is agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1]. While linoleic acid has been identified as the endogenous ligand for HNF4α its function remains ambiguous [4]. HNF4γ has yet to be paired with an endogenous ligand.


Hepatocyte nuclear factor-4-α / NR2A1 Show summary » More detailed page

Hepatocyte nuclear factor-4-γ / NR2A2 Show summary » More detailed page

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Frances M. Sladek. 2A. Hepatocyte nuclear factor-4 receptors. Accessed on 27/11/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=91.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Nuclear Hormone Receptors. Br J Pharmacol. 170: 1652–1675.