Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase (GTP diphosphate-lyase (cyclising)), E.C. 4.6.1.2, is a heterodimer comprising a β1 subunit and one of two alpha subunits (α1, α2) giving rise to two functionally indistinguishable isoforms, GC-1 (α1β1) and GC-2 (α2β1) [8,12]. A haem group is associated with the β subunit and is the target for the endogenous ligand NO, and, potentially, carbon monoxide [3]. The enzyme converts guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).

Enzymes

Complexes

GC-1 (Guanylyl cyclase, α1β1) C Show summary » More detailed page

GC-2 (Guanylyl cyclase, α2β1) C Show summary » More detailed page

Enzymes and Subunits

Guanylyl cyclase α1 subunit C Show summary »

Guanylyl cyclase α2 subunit C Show summary »

Guanylyl cyclase β1 subunit C Show summary »

Guanylyl cyclase β2 subunit C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Adrian Hobbs, Scott Waldman, Annie Beuve, Peter Brouckaert, John C. Burnett, Andreas Friebe, John Garthwaite, Doris Koesling, Michaela Kuhn, Lincoln Potter, Harald Schmidt. Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=939.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.