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ChEMBL ligand: CHEMBL260920 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2] | ||||||||
ChEMBL | Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrate | B | 4.47 | pKi | 33870 | nM | Ki | J Med Chem (2011) 54: 1640-1654 [PMID:21341673] |
ChEMBL | Competitive inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by Dixon plot analysis | B | 5.54 | pKi | 2900 | nM | Ki | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
GtoPdb | - | - | 5.54 | pKi | 2900 | nM | Ki | Proc Natl Acad Sci USA (2007) 104: 19767-72 [PMID:18056643] |
ChEMBL | Inhibition of lymphoid-specific tyrosine phosphatase F28A mutant | B | 4.46 | pIC50 | 35000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
ChEMBL | Inhibition of lymphoid-specific tyrosine phosphatase S35E mutant | B | 4.68 | pIC50 | 21000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
ChEMBL | Inhibition of lymphoid-specific tyrosine phosphatase K138A mutant | B | 4.72 | pIC50 | 19000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
ChEMBL | Inhibition of lymphoid-specific tyrosine phosphatase R33A mutant | B | 4.9 | pIC50 | 12500 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
ChEMBL | Inhibition of lymphoid-specific tyrosine phosphatase L29A mutant | B | 4.93 | pIC50 | 11800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
ChEMBL | Inhibition of lymphoid-specific tyrosine phosphatase C129S mutant | B | 5.09 | pIC50 | 8100 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
ChEMBL | Inhibition of lymphoid-specific tyrosine phosphatase | B | 5.34 | pIC50 | 4600 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
ChEMBL | Inhibition of Lyp-mediated pNPP hydrolysis | B | 5.34 | pIC50 | 4600 | nM | IC50 | Bioorg Med Chem (2012) 20: 1940-1946 [PMID:22133902] |
ChEMBL | Inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 294) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by spectrometric analysis | B | 5.34 | pIC50 | 4600 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
GtoPdb | In vitro measurement of PTPN22-catalysed substrate dephosphorylation, using pNPP as a substrate at pH 7.0, 25°C, and ionic strength of 0.15 M. | - | 5.34 | pIC50 | 4600 | nM | IC50 | Proc Natl Acad Sci USA (2007) 104: 19767-72 [PMID:18056643] |
ChEMBL | Inhibition of recombinant LyP assessed as hydrolysis of DiFMUP | B | 5.35 | pIC50 | 4500 | nM | IC50 | J Med Chem (2011) 54: 562-571 [PMID:21190368] |
ChEMBL | Inhibition of lymphoid-specific tyrosine phosphatase T36E mutant | B | 5.55 | pIC50 | 2800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
ChEMBL | Inhibition of PTP1B | B | 4.93 | pIC50 | 11800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
GtoPdb | - | - | 4.93 | pIC50 | 11800 | nM | IC50 | Proc Natl Acad Sci USA (2007) 104: 19767-72 [PMID:18056643] |
Protein-tyrosine phosphatase 1E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2976] [UniProtKB: Q12923] | ||||||||
ChEMBL | Inhibition of FAP1 | B | 4.43 | pIC50 | 36800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] | ||||||||
ChEMBL | Inhibition of SHP2 | B | 4.44 | pIC50 | 36000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
Protein-tyrosine phosphatase LC-PTP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2219] [UniProtKB: P35236] | ||||||||
ChEMBL | Inhibition of HePTP | B | 4.49 | pIC50 | 32100 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
Tyrosine-protein phosphatase non-receptor type 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6117] [UniProtKB: P43378] | ||||||||
ChEMBL | Inhibition of PTP-Meg2 | B | 4.5 | pIC50 | 31800 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]